公开(公告)号：US06589937B1

公开(公告)日：2003-07-08

申请号：US09171245

申请日：1998-10-14

申请人： Shuichi Tanabe ,  Yoshiyuki Shishido ,  Masayoshi Furushiro ,  Kunio Kado ,  Shusuke Hashimoto ,  Teruo Yokokura ,  Tetsuya Terasaki

发明人： Shuichi Tanabe ,  Yoshiyuki Shishido ,  Masayoshi Furushiro ,  Kunio Kado ,  Shusuke Hashimoto ,  Teruo Yokokura ,  Tetsuya Terasaki

IPC分类号： A61K3803

CPC分类号： C07K7/16 ,  A61K38/00 ,  C07K5/1019

摘要： New peptides represented by the following general formula (wherein X is OH or NH2, R is an amino acid residue selected from Arg, His, Lys, Methyl-Arg or Methyl-Tyr, n is an integer of 1-4, and in the case that n is 2-4, R may be identical with or different from each other) and an anti-dementia drug which contains one or more of these new peptides and has a high blood brain barrier (BBB) permeability and furthermore is low in a side effect.

摘要翻译： 由以下通式表示的新肽（其中X为OH或NH 2，R为选自Arg，His，Lys，Methyl-Arg或Methyl-Tyr的氨基酸残基，n为1-4的整数， n为2-4的情况，R可以相同或不同）和含有这些新肽中的一种或多种且具有高血脑屏障（BBB）渗透性的抗痴呆药物，此外，低 副作用。