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公开(公告)号：US20110124682A1
公开(公告)日：2011-05-26
申请号：US12999967
申请日：2009-06-18
IPC分类号： A61K31/4704 , A61P27/02
CPC分类号： A61K9/0048 , A61K31/4704 , A61K47/02 , A61K47/26
摘要： An object of the present invention is to provide a pharmaceutical composition containing rebamipide, which is unnecessary to be re-dispersed, has an enough transparency, and exhibits neutral to weakly acidic pH not to injure the keratoconjunctiva of a patient suffering from dry eye. The present pharmaceutical composition comprises (1) rebamipide, (2) an amino sugar, and (3) an buffer agent, which has no inorganic cation.
摘要翻译： 本发明的目的是提供一种含有瑞巴派特的药物组合物，其不需要再分散，具有足够的透明度，并且具有中性至弱酸性pH，不会损伤患有干眼症的患者的角膜结膜。 本药物组合物包含（1）瑞巴派特，（2）氨基糖，和（3）不含无机阳离子的缓冲剂。
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公开(公告)号：US07732611B2
公开(公告)日：2010-06-08
申请号：US10586453
申请日：2005-01-20
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D215/227
摘要： The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double H bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.
摘要翻译： 本发明提供由式（1）表示的喹诺酮衍生物形成的喹诺酮衍生物的胺盐[其中R是卤素原子; 侧链的取代位置是喹诺酮骨架中的3-或4-位; 并且喹诺酮骨架的3-和4-位之间的键合是单键或双键]和胺; 本发明由于具有优异的水溶性和优异的药理作用而用作治疗各种疾病的药物，特别是作为水性制剂。
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公开(公告)号：US08222276B2
公开(公告)日：2012-07-17
申请号：US12662610
申请日：2010-04-26
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/227
摘要： The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.
摘要翻译： 本发明提供由式（1）表示的喹诺酮衍生物形成的喹诺酮衍生物的胺盐[其中R是卤素原子; 侧链的取代位置是喹诺酮骨架中的3-或4-位; 并且喹诺酮骨架的3-和4-位之间的键合是单键或双键]和胺; 本发明由于具有优异的水溶性和优异的药理作用而用作治疗各种疾病的药物，特别是作为水性制剂。
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公开(公告)号：US20100210684A1
公开(公告)日：2010-08-19
申请号：US12662610
申请日：2010-04-26
IPC分类号： A61K31/47 , C07D215/227
CPC分类号： C07D215/227
摘要： The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.
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公开(公告)号：US20070155787A1
公开(公告)日：2007-07-05
申请号：US10586453
申请日：2005-01-20
IPC分类号： A61K31/4704 , C07D215/22
CPC分类号： C07D215/227
摘要： The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double H bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.
摘要翻译： 本发明提供由式（1）表示的喹诺酮衍生物形成的喹诺酮衍生物的胺盐[其中R是卤素原子; 侧链的取代位置是喹诺酮骨架中的3-或4-位; 并且喹诺酮骨架的3-和4-位之间的键合是单键或双H键]和胺; 本发明由于具有优异的水溶性和优异的药理作用而用作治疗各种疾病的药物，特别是作为水性制剂。
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