公开(公告)号：US20060004005A1

公开(公告)日：2006-01-05

申请号：US10949096

申请日：2004-09-24

申请人： Viswajanani Sattigeri ,  Mohammad Salman ,  Ramamurthi Narayanan ,  Subhendu Seth ,  Simi Sarin ,  Abhijit Ray ,  Sunanda Dastidar

发明人： Viswajanani Sattigeri ,  Mohammad Salman ,  Ramamurthi Narayanan ,  Subhendu Seth ,  Simi Sarin ,  Abhijit Ray ,  Sunanda Dastidar

IPC分类号： A61K31/53

CPC分类号： C07D251/52 ,  C07D251/16 ,  C07D251/18 ,  C07D251/50 ,  C07D251/54 ,  C07D251/70 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates to triazine derivatives as cell adhesion inhibitors. The compounds of this invention can be useful inter alia, for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis. The compounds can be used to formulate pharmacological compositions, and the methods of treating bronchial asthma, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided herein.

摘要翻译： 本发明涉及作为细胞粘附抑制剂的三嗪衍生物。 本发明的化合物尤其可用于抑制和预防细胞粘附和细胞粘附介导的病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣。 该化合物可用于配制药物组合物，本文还提供了使用该化合物治疗支气管哮喘，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎性和/或自身免疫性疾病的方法。

公开(公告)号：US20080207659A1

公开(公告)日：2008-08-28

申请号：US12031842

申请日：2008-02-15

申请人： Asit Kumar Chakraborti ,  Simi Sarin ,  Santosh Vijaykumar Rudrawar ,  Raj Kumar ,  Sunay Vijaykumar Chankeshwara ,  Abhijit Ray ,  Sunanda Ghosh Dastidar

发明人： Asit Kumar Chakraborti ,  Simi Sarin ,  Santosh Vijaykumar Rudrawar ,  Raj Kumar ,  Sunay Vijaykumar Chankeshwara ,  Abhijit Ray ,  Sunanda Ghosh Dastidar

IPC分类号： A61K31/506 ,  C07D239/20 ,  A61P19/02 ,  A61P29/00

CPC分类号： C07D403/04 ,  C07D401/04

摘要： The present invention relates to inhibitors of phosphodiesterase (PDE) type 4.Compounds disclosed herein can be useful for treating, preventing, inhibiting or suppressing asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), AIDS, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis or other inflammatory diseases, especially in humans.Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as phosphodiesterase (PDE) type 4 inhibitors are provided.

摘要翻译： 本发明涉及类型4的磷酸二酯酶（PDE）抑制剂。本文公开的化合物可用于治疗，预防，抑制或抑制哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性 特发性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），艾滋病，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎或其他炎性疾病。 提供制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）4型抑制剂的用途。