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公开(公告)号:US08236984B2
公开(公告)日:2012-08-07
申请号:US12728361
申请日:2010-03-22
申请人: Mark Brian Pepys , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Simon Kolstoe , Martin Smith
发明人: Mark Brian Pepys , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Simon Kolstoe , Martin Smith
CPC分类号: A61K31/194
摘要: The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. wherein X, Y, R1, R2, R3, R4, m, n, p, q, and the linker are as defined herein.
摘要翻译: 本发明涉及用于稳定转甲状腺素蛋白的四聚体形式的式(I)化合物,用于治疗或预防淀粉样变性的化合物,以及包含这些化合物的药剂和药物。 其中X,Y,R 1,R 2,R 3,R 4,m,n,p,q和连接体如本文所定义。
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公开(公告)号:US20100249233A1
公开(公告)日:2010-09-30
申请号:US12728361
申请日:2010-03-22
申请人: Mark Brian PEPYS , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Stephen Wood , Simon Kolstoe , Martin Smith
发明人: Mark Brian PEPYS , Steven Victor Ley , Angus John Morrison , Vittorio Bellotti , Stephen Wood , Simon Kolstoe , Martin Smith
IPC分类号: A61K31/196 , C07C229/58 , A61P43/00
CPC分类号: A61K31/194
摘要: The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. wherein X, Y, R1, R2, R3, R4, m, n, p, q, and the linker are as defined herein.
摘要翻译: 本发明涉及用于稳定转甲状腺素蛋白的四聚体形式的式(I)化合物,用于治疗或预防淀粉样变性的化合物,以及包含这些化合物的药剂和药物。 其中X,Y,R 1,R 2,R 3,R 4,m,n,p,q和连接体如本文所定义。
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