公开(公告)号：US20050220812A1

公开(公告)日：2005-10-06

申请号：US10505809

申请日：2003-02-25

申请人： Richard Titball ,  Carl Mayers ,  Melanie Duffield ,  Sonya Rowe ,  Julie Miller ,  Bryan Lingard

发明人： Richard Titball ,  Carl Mayers ,  Melanie Duffield ,  Sonya Rowe ,  Julie Miller ,  Bryan Lingard

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61P37/02 ,  C12Q1/70 ,  G01N33/15 ,  G01N33/554 ,  G01N33/569 ,  G01N33/68 ,  G06F19/18 ,  G06F19/22

CPC分类号： G16B20/00 ,  G16B30/00

摘要： A method for identifying a vaccine candidate, said method comprising selecting a protein from the proteome of a target organism on the basis of a property selected from a biophysical property or the amino acid composition of that protein. For example, using this method a first set of data for a said property of a one or more vaccine antigens of a particular genus is collected, and a control set of data for said property of one or more random proteins from the same genus is also collected. These datasets are then compared and statistical differences noted. The proteome of a target species may then be examined and one or more vaccine candidates selected from that proteome on the basis that they have a property more similar to that of the first set of data

摘要翻译： 一种鉴定疫苗候选物的方法，所述方法包括基于选自该蛋白质的生物物理性质或氨基酸组成的性质从靶生物体的蛋白质组中选择蛋白质。 例如，使用该方法收集特定属的一种或多种疫苗抗原的所述性质的第一组数据，并且来自同一属的一种或多种随机蛋白的所述性质的对照组数据也是 集。 然后对这些数据进行比较和统计差异。 然后可以检查目标物种的蛋白质组，并且基于它们具有与第一组数据相似的性质，从该蛋白质组中选出一种或多种疫苗候选物质