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公开(公告)号：US07537771B2
公开(公告)日：2009-05-26
申请号：US10332282
申请日：2001-07-06
申请人： Ethel Diane Williamson , Julie Miller , Nicola Jane Walker , Leslie William James Baillie , Paula Thomson Holden , Helen Claire Flick-Smith , Helen Lisa Bullifent , Richard William Titball , Andrew William Topping
发明人： Ethel Diane Williamson , Julie Miller , Nicola Jane Walker , Leslie William James Baillie , Paula Thomson Holden , Helen Claire Flick-Smith , Helen Lisa Bullifent , Richard William Titball , Andrew William Topping
CPC分类号： C07K14/32 , A61K39/00 , C07K2319/00 , C12N15/70
摘要： An immunogenic reagent which produces an immune response which is protective against Bacillus anthracis, said reagent comprising one or more polypeptides which together represent up to three domains of the full length Protective Antigen (PA) of B. anthracis or variants of these, and at least one of said domains comprises domain 1 or domain 4 of PA or a variant thereof. The polypeptides of the immunogenic reagent as well as full length PA are produced by expression from E. coli. High yields of polypeptide are obtained using this method. Cells, vectors and nucleic acids used in the method are also described and claimed.
摘要翻译： 产生免疫应答的免疫原性试剂，其为防止炭疽芽孢杆菌（Bacillus anthracis）提供免疫应答，所述试剂包含一个或多个多个共同代表炭疽芽孢杆菌或其变体的全长保护性抗原（PA）的三个结构域的多肽，至少 所述结构域之一包括PA的结构域1或结构域4或其变体。 免疫原性试剂的多肽以及全长PA通过来自大肠杆菌的表达产生。 使用该方法获得高产量的多肽。 还描述和要求保护该方法中使用的细胞，载体和核酸。
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公开(公告)号：US20050271669A1
公开(公告)日：2005-12-08
申请号：US10517074
申请日：2003-06-06
申请人： John Hohneker , Julie Miller , John Rothermel
发明人： John Hohneker , Julie Miller , John Rothermel
IPC分类号： A61K45/00 , A61K31/426 , A61K31/427 , A61K39/395 , A61K45/06 , A61P35/00 , A61P43/00 , C07D417/02 , C07K16/30
CPC分类号： C07K16/3015 , A61K31/426 , A61K31/427 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07D417/06 , A61K2300/00
摘要： The invention relates to a pharmaceutical combination which comprises (a) a HER-1 or a HER-2 antibody or (b) at least one antineoplastic agent selected from the group consisting of aromatase inhibitors, antiestrogens, topoisomerase I inhibitors, topoisomerase II inhibitors, microtubule active agents, protein kinase C inhibitors, anti-angiogenic compounds, gonadorelin agonists, anti-androgens, histone deacetylase inhibitors and S-adenosylmethionine decarboxylase inhibitors; and (c) an epothilone derivative of formula I and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular, for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.
摘要翻译： 本发明涉及药物组合，其包含（a）HER-1或HER-2抗体或（b）至少一种抗肿瘤剂，其选自芳香酶抑制剂，抗雌激素，拓扑异构酶I抑制剂，拓扑异构酶II抑制剂， 微管活性剂，蛋白激酶C抑制剂，抗血管生成化合物，促性腺激素激动剂，抗雄激素，组蛋白脱乙酰酶抑制剂和S-腺苷甲硫氨酸脱羧酶抑制剂; 和（c）式I的埃坡霉素衍生物和任选的至少一种用于同时，分别或顺序使用的药学上可接受的载体，特别是用于治疗增殖性疾病，特别是实体肿瘤疾病; 包含这种组合的药物组合物; 使用这种组合来制备用于治疗增殖性疾病的药物; 包括作为用于同时，分开或顺序使用的组合制剂的组合的商业包装或产品; 以及治疗温血动物，特别是人的方法。
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公开(公告)号：US06965351B1
公开(公告)日：2005-11-15
申请号：US10812593
申请日：2004-03-29
申请人： Julie Miller , William J. Taft
发明人： Julie Miller , William J. Taft
CPC分类号： H01Q15/0033 , H01Q1/288 , H01Q5/55 , H01Q19/191
摘要： An illuminating reflector system is provided for transmitting first and second frequency bands for satellite and terrestrial communications. The illuminating reflector includes a first reflector configured to transmit a first portion of the first frequency band in an dispersed beam, to reflect a second portion of the first frequency band, and to transmit the second frequency band; a second reflector configured to reflect the second frequency band received from the first reflector; and a primary reflector configured to receive the second portion of the first frequency band reflected from the first reflector, to receive the second frequency band reflected from the second reflector, and to reflect the second portion of the first frequency band and the second frequency band in a substantially collimated beam.
摘要翻译： 提供照明反射器系统用于发送用于卫星和地面通信的第一和第二频带。 所述照明反射器包括：第一反射器，被配置为在分散光束中传输所述第一频带的第一部分，以反射所述第一频带的第二部分，并传输所述第二频带; 第二反射器，被配置为反射从第一反射器接收的第二频带; 以及主反射器，被配置为接收从第一反射器反射的第一频带的第二部分，以接收从第二反射器反射的第二频带，并将第一频带和第二频带的第二部分反射 一个基本准直的光束。
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公开(公告)号：US20050220812A1
公开(公告)日：2005-10-06
申请号：US10505809
申请日：2003-02-25
申请人： Richard Titball , Carl Mayers , Melanie Duffield , Sonya Rowe , Julie Miller , Bryan Lingard
发明人： Richard Titball , Carl Mayers , Melanie Duffield , Sonya Rowe , Julie Miller , Bryan Lingard
IPC分类号： A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61P37/02 , C12Q1/70 , G01N33/15 , G01N33/554 , G01N33/569 , G01N33/68 , G06F19/18 , G06F19/22
摘要： A method for identifying a vaccine candidate, said method comprising selecting a protein from the proteome of a target organism on the basis of a property selected from a biophysical property or the amino acid composition of that protein. For example, using this method a first set of data for a said property of a one or more vaccine antigens of a particular genus is collected, and a control set of data for said property of one or more random proteins from the same genus is also collected. These datasets are then compared and statistical differences noted. The proteome of a target species may then be examined and one or more vaccine candidates selected from that proteome on the basis that they have a property more similar to that of the first set of data
摘要翻译： 一种鉴定疫苗候选物的方法，所述方法包括基于选自该蛋白质的生物物理性质或氨基酸组成的性质从靶生物体的蛋白质组中选择蛋白质。 例如，使用该方法收集特定属的一种或多种疫苗抗原的所述性质的第一组数据，并且来自同一属的一种或多种随机蛋白的所述性质的对照组数据也是 集。 然后对这些数据进行比较和统计差异。 然后可以检查目标物种的蛋白质组，并且基于它们具有与第一组数据相似的性质，从该蛋白质组中选出一种或多种疫苗候选物质
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公开(公告)号：US08105613B2
公开(公告)日：2012-01-31
申请号：US11886170
申请日：2006-03-10
申请人： Helen Claire Flick-Smith , James Edward Eyles , Emma Louise Waters , Nicola Jane Walker , Ethel Diane Williamson , Leslie William Baillie , Julie Miller
发明人： Helen Claire Flick-Smith , James Edward Eyles , Emma Louise Waters , Nicola Jane Walker , Ethel Diane Williamson , Leslie William Baillie , Julie Miller
CPC分类号： A61K39/39 , A61K39/07 , A61K2039/543 , A61K2039/55516 , Y02A50/407
摘要： Spore coat-associated proteins from members of Bacillus genera, and in particular spore-coat associated protein N (CotN), have utilization as adjuvants in vaccine formulations. The vaccine formulations most likely contain a virulence factor of bacterial origin, which in the case of Bacillus genera is the protective antigen.
摘要翻译： 来自芽孢杆菌属的孢子外壳相关蛋白，特别是孢子外壳相关蛋白N（CotN））在疫苗制剂中具有作为佐剂的利用。 疫苗制剂最可能含有细菌来源的毒力因子，在属于芽孢杆菌属的情况下是保护性抗原。
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公开(公告)号：US20100015181A1
公开(公告)日：2010-01-21
申请号：US11886170
申请日：2006-03-10
申请人： Helen Claire Flick-Smith , James Edward Eyles , Emma Louise Waters , Nicola Jane Walker , Ethel Diane Williamson , Leslie William Baillie , Julie Miller
发明人： Helen Claire Flick-Smith , James Edward Eyles , Emma Louise Waters , Nicola Jane Walker , Ethel Diane Williamson , Leslie William Baillie , Julie Miller
IPC分类号： A61K39/07
CPC分类号： A61K39/39 , A61K39/07 , A61K2039/543 , A61K2039/55516 , Y02A50/407
摘要： Spore coat-associated proteins from members of Bacillus genera, and in particular spore-coat associated protein N (CotN), have utilisation as adjuvants in vaccine formulations. The vaccine formulations most likely contain a virulence factor of bacterial origin, which in the case of Bacillus genera is the protective antigen.
摘要翻译： 来自芽孢杆菌属的孢子外壳相关蛋白，特别是孢子外壳相关蛋白N（CotN））在疫苗制剂中具有作为佐剂的利用。 疫苗制剂最可能含有细菌来源的毒力因子，在属于芽孢杆菌属的情况下是保护性抗原。
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公开(公告)号：US07015867B1
公开(公告)日：2006-03-21
申请号：US10812535
申请日：2004-03-29
申请人： Julie Miller , William J. Taft
发明人： Julie Miller , William J. Taft
CPC分类号： H01Q19/193 , H01Q19/062 , H01Q25/002
摘要： An illuminating-reflector system is provided for transmitting a frequency band in an dispersed beam and a substantially collimated beam. The system includes a secondary reflector configured to transmit a first portion of the frequency band to form the dispersed beam and to reflect a second portion of the frequency band; and a primary reflector configured to receive the second portion of the frequency band reflected from the secondary reflector and to reflect the second portion of the frequency band to form the substantially collimated beam.
摘要翻译： 提供照明反射器系统，用于传输分散光束和基本上准直的光束中的频带。 该系统包括辅助反射器，其被配置为传送频带的第一部分以形成分散的光束并且反射该频带的第二部分; 以及主反射器，其被配置为接收从次级反射器反射的频带的第二部分并且反射该频带的第二部分以形成基本上准直的光束。
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公开(公告)号：US20130164823A1
公开(公告)日：2013-06-27
申请号：US13627071
申请日：2012-09-26
申请人： Ethel Diane Williamson , Julie Miller , Nicola Jane Walker , Leslie William James Baillie , Paula Thomson Holden , Helen Claire Flick-Smith , Helen Lisa Bullifent , Richard William Titball , Andrew William Topping
发明人： Ethel Diane Williamson , Julie Miller , Nicola Jane Walker , Leslie William James Baillie , Paula Thomson Holden , Helen Claire Flick-Smith , Helen Lisa Bullifent , Richard William Titball , Andrew William Topping
IPC分类号： C12N15/70
CPC分类号： C07K14/32 , A61K39/00 , C07K2319/00 , C12N15/70
摘要： An immunogenic reagent which produces an immune response which is protective against Bacillus anthracis, said reagent comprising one or more polypeptides which together represent up to three domains of the full length Protective Antigen (PA) of B. anthracis or variants of these, and at least one of said domains comprises domain 1 or domain 4 of PA ro a variant thereof. The polypeptides of the immunogenic reagent as well as full length PA are produced by expression from E. coli. High yields of polypeptide are obtained using this method. Cells, vectors and nucleic acids used in the method are also described and claimed.
摘要翻译： 产生免疫应答的免疫原性试剂，其为防止炭疽芽孢杆菌（Bacillus anthracis）提供免疫应答，所述试剂包含一个或多个多个共同代表炭疽芽孢杆菌或其变体的全长保护性抗原（PA）的三个结构域的多肽，至少 所述结构域之一包括其变体PA的结构域1或结构域4。 免疫原性试剂的多肽以及全长PA通过来自大肠杆菌的表达产生。 使用该方法获得高产量的多肽。 还描述和要求保护该方法中使用的细胞，载体和核酸。
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公开(公告)号：US20100266639A1
公开(公告)日：2010-10-21
申请号：US11728384
申请日：2007-03-26
申请人： Ethel Diane Williamson , Julie Miller , Nicola Jane Walker , Leslie William James Baillie , Paula Thomson Holden , Helen Claire Flick-Smith , Helen Lisa Bullifent , Richard William Titball , Andrew William Topping
发明人： Ethel Diane Williamson , Julie Miller , Nicola Jane Walker , Leslie William James Baillie , Paula Thomson Holden , Helen Claire Flick-Smith , Helen Lisa Bullifent , Richard William Titball , Andrew William Topping
CPC分类号： C07K14/32 , A61K39/00 , C07K2319/00 , C12N15/70
摘要： An immunogenic reagent which produces an immune response which is protective against Bacillus anthracis, said reagent comprising one or more polypeptides which together represent up to three domains of the full length Protective Antigen (PA) of B. anthracis or variants of these, and at least one of said domains comprises domain 1 or domain 4 of PA or a variant thereof. The polypeptides of the immunogenic reagent as well as full length PA are produced by expression from E. coli. High yields of polypeptide are obtained using this method. Cells, vectors and nucleic acids used in the method are also described and claimed.
摘要翻译： 产生免疫应答的免疫原性试剂，其为防止炭疽芽孢杆菌（Bacillus anthracis）提供免疫应答，所述试剂包含一个或多个多个共同代表炭疽芽孢杆菌或其变体的全长保护性抗原（PA）的三个结构域的多肽，至少 所述结构域之一包括PA的结构域1或结构域4或其变体。 免疫原性试剂的多肽以及全长PA通过来自大肠杆菌的表达产生。 使用该方法获得高产量的多肽。 还描述和要求保护该方法中使用的细胞，载体和核酸。
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公开(公告)号：US07270991B2
公开(公告)日：2007-09-18
申请号：US10483150
申请日：2002-07-09
摘要： A recombinant microorganism comprises an asporogenic Bacillus subtilis strain in which a gene encoding a protease enzyme has been downregulated or inactivated. In particular sigma factorspoIIAC is inactivated such that the strain is asporogenic. These strains are particularly useful as expression vehicles for proteins such as protective antigen (PA) of Bacillus anthracis.
摘要翻译： 重组微生物包含其中编码蛋白酶的基因已被下调或失活的异源枯草芽孢杆菌菌株。 特别是sigma因子pIIAC被灭活，使得菌株是异源的。 这些菌株特别可用作蛋白质的表达载体，例如炭疽芽孢杆菌的保护性抗原（PA）。
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