公开(公告)号：US5801254A

公开(公告)日：1998-09-01

申请号：US906612

申请日：1997-08-05

Applicant: Byoung-Mog Kwon ,  Song-Hae Bok ,  Seung-Ho Lee ,  Young-Kook Kim ,  Mi-Jeong Kim ,  Jongheon Shin ,  Youngwan Seo ,  Soo-Ik Chang

Inventor： Byoung-Mog Kwon ,  Song-Hae Bok ,  Seung-Ho Lee ,  Young-Kook Kim ,  Mi-Jeong Kim ,  Jongheon Shin ,  Youngwan Seo ,  Soo-Ik Chang

IPC: C07D493/10 ,  C07D307/94

CPC classification number: C07D493/10

Abstract: Arteminolides obtained from Artemisia sylvatica MAXIMOWICZ and having a core structure of formula (I) or an isomeric structure thereof are effective farnesyl-protein transferase inhibitors as well as angiogenesis suppressors, and, accordingly, they are useful for the treatment of various cancers and angiogenesis-related diseases. ##STR1##

Abstract translation: 具有式（I）的核心结构或其异构体结构的从艾蒿获得的青蒿素是有效的法呢基 - 蛋白转移酶抑制剂以及血管发生抑制因子，因此它们可用于治疗各种癌症和血管生成 - 相关疾病 （一）

公开(公告)号：US06387948B1

公开(公告)日：2002-05-14

申请号：US09596363

申请日：2000-06-17

Applicant: Byoung-Mog Kwon ,  Kwang-Hee Son ,  Ha-Won Jeong ,  Seung-Ho Lee ,  Mi-Young Han ,  Hyun-Mi Kang ,  Hyae-Kyeong Kim ,  Soo-Ik Chang

Inventor： Byoung-Mog Kwon ,  Kwang-Hee Son ,  Ha-Won Jeong ,  Seung-Ho Lee ,  Mi-Young Han ,  Hyun-Mi Kang ,  Hyae-Kyeong Kim ,  Soo-Ik Chang

IPC: A61K31343

CPC classification number: A61K31/343

Abstract: 8-Acetylarteminolide of the formula (I) having inhibitory activities against farnesyl-protein transferase(FPTase), a progression of the cell cycle and angiogenesis may be useful for the prevention and treatment of various cancers and angiogenesis-related diseases:

Abstract translation: 具有对法呢基 - 蛋白转移酶（FPTase）的抑制活性的式（I）的8-乙酰胆碱酯酶，细胞周期和血管发生的进展可用于预防和治疗各种癌症和血管发生相关疾病：

公开(公告)号：US07604982B2

公开(公告)日：2009-10-20

申请号：US10566532

申请日：2004-11-26

Applicant: Moon-Hi Han ,  In-Cheol Kang ,  Yoon-Suk Lee ,  Soo-Ik Chang

Inventor： Moon-Hi Han ,  In-Cheol Kang ,  Yoon-Suk Lee ,  Soo-Ik Chang

IPC: C12M3/00

CPC classification number: G01N33/54366 ,  C07K7/06 ,  C40B30/04 ,  G01N33/6842 ,  G01N2333/70546 ,  G01N2333/70557 ,  G01N2500/02

Abstract: The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.

Abstract translation: 本发明涉及使用蛋白质芯片的整联蛋白拮抗物质的筛选方法和由此筛选的有用肽。 用于本发明的蛋白质芯片是用新材料，杯芳烃衍生物涂覆的独特的底物，其可以保持蛋白质的均匀和高活性。 整合素受体蛋白在芯片上高密度排列，可以筛选特异性抑制配体结合的材料（蛋白质，肽，小分子等）。 本发明中使用的整联蛋白是整合素av f3 3和整联蛋白a1，b j3 3，从肽文库筛选的新拮抗肽具有高结合亲和力。

公开(公告)号：US20070249061A1

公开(公告)日：2007-10-25

申请号：US10566532

申请日：2004-11-26

Applicant: Moon-Hi Han ,  In-Cheol Kang ,  Yoon-Suk Lee ,  Soo-Ik Chang

Inventor： Moon-Hi Han ,  In-Cheol Kang ,  Yoon-Suk Lee ,  Soo-Ik Chang

IPC: A61K48/00 ,  G01N33/68

CPC classification number: G01N33/54366 ,  C07K7/06 ,  C40B30/04 ,  G01N33/6842 ,  G01N2333/70546 ,  G01N2333/70557 ,  G01N2500/02

Abstract: The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.

Abstract translation: 本发明涉及使用蛋白质芯片的整联蛋白拮抗物质的筛选方法和由此筛选的有用肽。 用于本发明的蛋白质芯片是用新材料，杯芳烃衍生物涂覆的独特的底物，其可以保持蛋白质的均匀和高活性。 整合素受体蛋白在芯片上高密度排列，可以筛选特异性抑制配体结合的材料（蛋白质，肽，小分子等）。 本发明中使用的整联蛋白是整合素av f3 3和整联蛋白a1，b j3 3，从肽文库筛选的新拮抗肽具有高结合亲和力。

公开(公告)号：US06770457B1

公开(公告)日：2004-08-03

申请号：US09701265

申请日：2000-11-27

Applicant: Weon Kyoo You ,  Seung Ho So ,  Byung Cheul Ahn ,  Hyosil Lee ,  Soo-Il Jung ,  Young jo Kim ,  Jong Hyuk Lee ,  Yong-Kil Hong ,  Young Ae Joe ,  Soo-Ik Chang

Inventor： Weon Kyoo You ,  Seung Ho So ,  Byung Cheul Ahn ,  Hyosil Lee ,  Soo-Il Jung ,  Young jo Kim ,  Jong Hyuk Lee ,  Yong-Kil Hong ,  Young Ae Joe ,  Soo-Ik Chang

IPC: C12P2106

CPC classification number: C12N9/6435 ,  A61K38/00 ,  C07K14/475 ,  C12Y304/21007

Abstract: The present invention relates to process of purifying the angiogensis inhibitor proteins expressed in E. coli and to the use of recombinant kringle 1-3 (; greenstatin) purified by the above process as a angiogenesis inhibitor and an anticancer agent. Particularly, according to the process of purifying the protein, the angiogenesis inhibitor proteins overexpressed are solubilized, refolded, and purified as a pure and active form. The greenstatin purified by the process specifically suppresses endothelial cell proliferation, anaiogenesis, and the growth of lung cancer, skin cancer, and brain tumor. Therefore, the process of this invention is applicable to the mass-production of angiogenesis inhibitor proteins such as greenstatin which is useful for the treatment of glaucoma, retinopathy, and cancers.

Abstract translation: 本发明涉及纯化在大肠杆菌中表达的血管紧张素抑制剂蛋白质的方法，以及通过上述方法纯化的重组三环酮1-3（;绿色抑制素）作为血管生成抑制剂和抗癌剂的用途。 特别地，根据纯化蛋白质的过程，过表达的血管生成抑制蛋白被溶解，重折叠并纯化为纯的和活性的形式。 通过该方法纯化的绿素抑制剂特异性抑制内皮细胞增殖，发生发生，以及肺癌，皮肤癌和脑肿瘤的生长。 因此，本发明的方法适用于批量生产可用于治疗青光眼，视网膜病变和癌症的绿调素抑制剂等血管发生抑制蛋白。