公开(公告)号：US20090181973A1

公开(公告)日：2009-07-16

申请号：US11596428

申请日：2005-11-16

申请人： Soon-Kyoung Kwon ,  Yong-Soo Lee ,  Hae-Sun Park

发明人： Soon-Kyoung Kwon ,  Yong-Soo Lee ,  Hae-Sun Park

IPC分类号： A61K31/50 ,  C07D237/18 ,  A61P35/00

CPC分类号： A61K31/50

摘要： The present invention relates to a medicinal composition for preventing or treating pancreatic cancer, comprising 3-alkoxy-6-allylthiopyridazine or a pharmaceutically acceptable salt thereof as an effective ingredient. An MTT assay, to assess the viability of cells, and flow cytometric analysis, to measure apoptotic cell death, were performed, and the results, which revealed that the compound and pharmaceutically acceptable salts thereof have preventive and therapeutic activity against pancreatic cancer, are presented herein.

摘要翻译： 本发明涉及用于预防或治疗胰腺癌的药物组合物，其包含3-烷氧基-6-烯丙硫基哒嗪或其药学上可接受的盐作为有效成分。 进行了用于评估细胞活力的MTT测定和流式细胞术分析以测量凋亡细胞死亡，结果表明该化合物及其药学上可接受的盐具有对胰腺癌的预防和治疗活性 这里。

公开(公告)号：US5942511A

公开(公告)日：1999-08-24

申请号：US098275

申请日：1998-06-16

申请人： Soon Kyoung Kwon ,  Sang Geon Kim ,  Young Nam Park ,  Mi Kyung Kim ,  Sung Hee Choi ,  Hea Soon Shin

发明人： Soon Kyoung Kwon ,  Sang Geon Kim ,  Young Nam Park ,  Mi Kyung Kim ,  Sung Hee Choi ,  Hea Soon Shin

IPC分类号： A61K31/495 ,  A61K31/50 ,  A61P1/16 ,  A61P43/00 ,  C07D237/18 ,  C07D237/30 ,  C07D237/32

CPC分类号： C07D237/18

摘要： The, present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment or hepatic diseases induced by toxic substances and for protection of human tissues from radiation: ##STR1## or a pharmaceutically acceptable salt thereof, in which R.sub.1 represents halogen atom, lower alkoxy, dialkylaminoalkoxy, hydroxyalkoxy, phenoxy substituted or unsubstituted with lower alkyl, benzyloxy, or phenyl, andR.sub.2 and R.sub.3 independently of one another represent hydrogen or lower alkyl, or R.sub.2 and R.sub.3 together with carbon atom to which they are attached can form a saturated or unsaturated 6-membered ring,provided that R.sub.2 and R.sub.3 are other than hydrogen when R.sub.1 is chloro; and to a process for preparing thereof and a pharmaceutical composition containing the same as an effective component.

摘要翻译： 本发明涉及一种由式（I）表示的新颖的烯丙基硫代哒嗪衍生物，其具有优异的预防和治疗效果或由有毒物质引起的肝脏疾病和用于保护人体组织免受辐射的效果：或其药学上可接受的盐，其中 R 1表示卤素原子，低级烷氧基，二烷基氨基烷氧基，羟基烷氧基，被低级烷基，苄氧基或苯基取代或未取代的苯氧基，R2和R3彼此独立地表示氢或低级烷基，或R2和R3与它们 连接时可以形成饱和或不饱和的6元环，条件是当R 1为氯时，R 2和R 3不是氢; 以及其制备方法和含有该组合物的药物组合物作为有效成分。