公开(公告)号：US20100112098A1

公开(公告)日：2010-05-06

申请号：US12263292

申请日：2008-10-31

申请人： Benoit Lemaire ,  Sophie Lafay ,  Karine Nardon ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

发明人： Benoit Lemaire ,  Sophie Lafay ,  Karine Nardon ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

IPC分类号： A61K36/82 ,  A61K31/235

CPC分类号： A61K31/235

摘要： A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 5-caffeoylquinic acid (5-CQA) and total chlorogenic acids (tCGA) (5-CQA/tCGA) of between about 0.2 and 0.3. More preferably, the concentration of tCGA is greater than about 45% and the concentration of 5-CQA is less than about 10%. A preferred method of administration consists of administering between about 200 mg and about 1,000 mg per day, more preferably administering about 400 mg per day.

摘要翻译： 一种通过施用一定量的有效治疗受试者的脱咖啡因生咖啡提取物来控制人体重的方法。 一种优选的生咖啡提取物含有约5-30％的5-咖啡酰奎宁酸（5-CQA）和总绿原酸（tCGA）（5-CQA / tCGA）之比。 更优选地，tCGA的浓度大于约45％，并且5-CQA的浓度小于约10％。 优选的给药方法包括每天施用约200mg至约1,000mg，更优选每天施用约400mg。

公开(公告)号：US20100047372A1

公开(公告)日：2010-02-25

申请号：US12195303

申请日：2008-08-20

申请人： Benoit LEMAIRE ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

发明人： Benoit LEMAIRE ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

IPC分类号： A61K31/353 ,  A61K36/87 ,  A61P43/00

CPC分类号： A61K36/87

摘要： A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5% by weight, and more preferably within a range from about 12% by weight to about 50% by weight, and a concentration of flavanol dimers preferably greater than about 2% by weight, and more preferably within a range from about 6% by weight to about 20% by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.

摘要翻译： 通过施用一定量的有效治疗受试者的葡萄提取物来增强运动期间的身体表现的方法。 优选的葡萄提取物包含大于约5重量％，更优选在约12重量％至约50重量％范围内的黄烷醇单体的浓度，并且黄烷醇二聚体的浓度优选大于约2重量％ ，更优选在约6重量％至约20重量％的范围内。 黄烷醇单体优选包括儿茶素，表儿茶素，表儿茶素没食子酸酯和没食子酸。 黄烷醇二聚体优选包括原花青素B1，原花青素B2，原花青素B3，原花青素B4和原花青素B2-O-没食子酸酯。

公开(公告)号：US08980342B2

公开(公告)日：2015-03-17

申请号：US12195303

申请日：2008-08-20

申请人： Benoit Lemaire ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques DiKansky

发明人： Benoit Lemaire ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques DiKansky

IPC分类号： A61K36/87 ,  A61K36/00

CPC分类号： A61K36/87

摘要： A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5% by weight, and more preferably within a range from about 12% by weight to about 50% by weight, and a concentration of flavanol dimers preferably greater than about 2% by weight, and more preferably within a range from about 6% by weight to about 20% by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.

摘要翻译： 通过施用一定量的有效治疗受试者的葡萄提取物来增强运动期间的身体表现的方法。 优选的葡萄提取物包含大于约5重量％，更优选在约12重量％至约50重量％范围内的黄烷醇单体的浓度，并且黄烷醇二聚体的浓度优选大于约2重量％ ，更优选在约6重量％至约20重量％的范围内。 黄烷醇单体优选包括儿茶素，表儿茶素，表儿茶素没食子酸酯和没食子酸。 黄烷醇二聚体优选包括原花青素B1，原花青素B2，原花青素B3，原花青素B4和原花青素B2-O-没食子酸酯。