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公开(公告)号:US08999320B2
公开(公告)日:2015-04-07
申请号:US12865615
申请日:2009-01-30
申请人: Thomas P. Sakmar , Thomas Huber , Sourabh Banerjee
发明人: Thomas P. Sakmar , Thomas Huber , Sourabh Banerjee
CPC分类号: A61K9/1277 , A61K9/127 , A61K9/1275 , A61K45/06
摘要: Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly obtaining a NABB not associated with membrane proteins. Immunogenic compositions comprising NABBs with native conformational epitopes are also provided along with their methods of use.
摘要翻译: 提供了与至少一种膜蛋白相关的快速获得纳米级载脂蛋白结合磷脂双层(NABB)的方法。 还公开了用于快速获得与膜蛋白不相关的NABB的方法。 还提供包含具有天然构象表位的NABB的免疫原性组合及其使用方法。
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2.
公开(公告)号:US20110059159A1
公开(公告)日:2011-03-10
申请号:US12865615
申请日:2009-01-30
申请人: Thomas P. Sakmar , Thomas Huber , Sourabh Banerjee
发明人: Thomas P. Sakmar , Thomas Huber , Sourabh Banerjee
IPC分类号: A61K9/127 , A61K31/56 , A61K38/22 , A61K31/7048 , A61K31/4174 , A61K31/337 , A61K31/704 , A61K38/13 , A61K31/472 , A61K31/05 , A61K31/5513 , A61K31/11 , A61K31/07 , A61K31/203 , A61K31/122 , A61P35/00 , A61P37/06 , A61P31/12 , A61P31/10 , A61P3/02 , A61P23/00 , A61P25/20 , A61P37/02 , B82Y5/00
CPC分类号: A61K9/1277 , A61K9/127 , A61K9/1275 , A61K45/06
摘要: Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly obtaining a NABB not associated with membrane proteins. Immunogenic compositions comprising NABBs with native conformational epitopes are also provided along with their methods of use.
摘要翻译: 提供了与至少一种膜蛋白相关的快速获得纳米级载脂蛋白结合磷脂双层(NABB)的方法。 还公开了用于快速获得与膜蛋白不相关的NABB的方法。 还提供包含具有天然构象表位的NABB的免疫原性组合及其使用方法。
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