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    SYNERGISTIC COMBINATION AND METHOD THEREOF
    2.
    发明申请
    SYNERGISTIC COMBINATION AND METHOD THEREOF 失效
    协同组合及其方法

    公开(公告)号：US20120003268A1

    公开(公告)日：2012-01-05

    申请号：US13173833

    申请日：2011-06-30

    申请人： Dipankar NANDI ,  Srabanti RAKSHIT ,  Manikandan PONNUSAMY

    发明人： Dipankar NANDI ,  Srabanti RAKSHIT ,  Manikandan PONNUSAMY

    IPC分类号： A61K39/04 ,  A61P37/02 ,  A61P35/00

    CPC分类号： A61K35/74 ,  A61K31/675 ,  A61K2039/521 ,  A61K2039/585 ,  A61K2300/00

    摘要： A method for the treatment of myeloma and thymoma by administering a therapeutically effective dose of Mycobacterium indicus pranii with Cyclophosphamide. This disclosure generally relates to the field of cancer biology. More specifically, this disclosure relates to the immunotherapeutic treatment of myeloma and thymoma, using a combination of heat killed Mycobacterium indicus pranii and the widely administered chemotherapeutic drug, Cyclophosphamide. Mycobacterium indicus pranii has already shown its efficacy as an immunomodulator and has been safely administered to humans. The most common method of cancer management is the application of chemotherapeutic drugs which results in side-effects. At lower non-toxic doses Cyclophosphamide is not effective. The present disclosure discloses a method of improving efficacy of non-toxic doses of Cyclophosphamide by administrating it together with Mycobacterium indicus pranii. This disclosure is relevant for the treatment of other lymphomas as well.

    摘要翻译： 一种治疗骨髓瘤和胸腺瘤的方法，其通过用环磷酰胺施用治疗有效剂量的分枝杆菌分枝杆菌。 本公开一般涉及癌症生物学领域。 更具体地，本公开涉及使用热杀死的分枝杆菌分枝杆菌和广泛施用的化疗药物环磷酰胺的组合对骨髓瘤和胸腺瘤的免疫治疗性治疗。 分枝杆菌分枝杆菌已经显示其作为免疫调节剂的功效并且已被安全地施用给人类。 最常见的癌症治疗方法是化疗药物的应用，导致副作用。 在较低的无毒剂量下，环磷酰胺无效。 本公开公开了一种通过将其与分枝杆菌分枝杆菌一起施用来提高无毒剂量的环磷酰胺的功效的方法。 本公开也涉及治疗其他淋巴瘤。

    Synergistic combination and method thereof
    4.
    发明授权
    Synergistic combination and method thereof 失效
    协同组合及其方法

    公开(公告)号：US08367075B2

    公开(公告)日：2013-02-05

    申请号：US13173833

    申请日：2011-06-30

    申请人： Dipankar Nandi ,  Srabanti Rakshit ,  Manikandan Ponnusamy

    发明人： Dipankar Nandi ,  Srabanti Rakshit ,  Manikandan Ponnusamy

    IPC分类号： A61K39/04 ,  A61K49/00 ,  A61K48/00

    CPC分类号： A61K35/74 ,  A61K31/675 ,  A61K2039/521 ,  A61K2039/585 ,  A61K2300/00

    摘要： A method for the treatment of myeloma and thymoma by administering a therapeutically effective dose of Mycobacterium indicus pranii with Cyclophosphamide. This disclosure generally relates to the field of cancer biology. More specifically, this disclosure relates to the immunotherapeutic treatment of myeloma and thymoma, using a combination of heat killed Mycobacterium indicus pranii and the widely administered chemotherapeutic drug, Cyclophosphamide. Mycobacterium indicus pranii has already shown its efficacy as an immunomodulator and has been safely administered to humans. The most common method of cancer management is the application of chemotherapeutic drugs which results in side-effects. At lower non-toxic doses Cyclophosphamide is not effective. The present disclosure discloses a method of improving efficacy of non-toxic doses of Cyclophosphamide by administrating it together with Mycobacterium indicus pranii. This disclosure is relevant for the treatment of other lymphomas as well.

    摘要翻译： 一种治疗骨髓瘤和胸腺瘤的方法，其通过用环磷酰胺施用治疗有效剂量的分枝杆菌分枝杆菌。 本公开一般涉及癌症生物学领域。 更具体地，本公开涉及使用热灭活的分枝杆菌和广泛施用的化学治疗药物环磷酰胺的组合对骨髓瘤和胸腺瘤的免疫治疗性治疗。 分枝杆菌分枝杆菌已经显示其作为免疫调节剂的功效并且已被安全地施用给人类。 最常见的癌症治疗方法是化疗药物的应用，导致副作用。 在较低的无毒剂量下，环磷酰胺无效。 本公开公开了一种通过将其与分枝杆菌分枝杆菌一起施用来提高无毒剂量的环磷酰胺的功效的方法。 本公开也涉及治疗其他淋巴瘤。