公开(公告)号：US07271152B2

公开(公告)日：2007-09-18

申请号：US10476237

申请日：2002-05-03

申请人： Lisa Alaimo ,  Veronica Alves ,  Patrick Andre ,  David Phillips ,  Sri R. Prasad ,  Denisa D. Wagner

发明人： Lisa Alaimo ,  Veronica Alves ,  Patrick Andre ,  David Phillips ,  Sri R. Prasad ,  Denisa D. Wagner

IPC分类号： A61K38/04

CPC分类号： A61K38/57 ,  A61K31/00 ,  A61K38/12 ,  A61K2300/00

摘要： The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.

摘要翻译： 本发明涉及能够调节CD154动员并且可用于稳定血栓形成过程并减少参与炎性反应的细胞活化的化合物。 本发明还涉及用于鉴定这些化合物的方法。 本发明还涉及用金属蛋白酶抑制剂输血的血小板治疗或预防炎症。 本发明还包括治疗与这种生物过程相关的损伤和疾病的组合物和方法。