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7 条记录 (耗时 0.042 秒)

    Compounds and methods for the modulation of CD154
    1.
    发明授权
    Compounds and methods for the modulation of CD154 有权
    用于调节CD154的化合物和方法

    公开(公告)号：US07271152B2

    公开(公告)日：2007-09-18

    申请号：US10476237

    申请日：2002-05-03

    申请人： Lisa Alaimo ,  Veronica Alves ,  Patrick Andre ,  David Phillips ,  Sri R. Prasad ,  Denisa D. Wagner

    发明人： Lisa Alaimo ,  Veronica Alves ,  Patrick Andre ,  David Phillips ,  Sri R. Prasad ,  Denisa D. Wagner

    IPC分类号： A61K38/04

    CPC分类号： A61K38/57 ,  A61K31/00 ,  A61K38/12 ,  A61K2300/00

    摘要： The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.

    摘要翻译： 本发明涉及能够调节CD154动员并且可用于稳定血栓形成过程并减少参与炎性反应的细胞活化的化合物。 本发明还涉及用于鉴定这些化合物的方法。 本发明还涉及用金属蛋白酶抑制剂输血的血小板治疗或预防炎症。 本发明还包括治疗与这种生物过程相关的损伤和疾病的组合物和方法。

    METHODS FOR DIAGNOSING AND TREATING HEMOSTATIC DISORDERS BY MODULATING P-SELECTIN ACTIVITY
    3.
    发明申请
    METHODS FOR DIAGNOSING AND TREATING HEMOSTATIC DISORDERS BY MODULATING P-SELECTIN ACTIVITY 审中-公开
    通过调节P-选择素活性来诊断和治疗嗜酸粒细胞性疾病的方法

    公开(公告)号：US20080193949A1

    公开(公告)日：2008-08-14

    申请号：US12030576

    申请日：2008-02-13

    申请人： Denisa D. Wagner ,  Patrick Andre ,  Daqing W. Hartwell ,  Ingrid Hrachovinova

    发明人： Denisa D. Wagner ,  Patrick Andre ,  Daqing W. Hartwell ,  Ingrid Hrachovinova

    IPC分类号： G01N33/566

    CPC分类号： G01N33/86 ,  A61K38/178 ,  A61K48/00 ,  C07K2319/30 ,  G01N2333/70564

    摘要： The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity as modulators of hemostasis. The invention also relates to methods and compositions for the diagnosis and treatment of hemostatic disorders, including, but not limited to, hemorrhagic disorders and thrombotic disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hemostatic conditions, and for the identification of subjects exhibiting a predisposition to such conditions. In addition, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of a hemostatic or vascular disorders, and for monitoring the efficacy of compounds in clinical trials.

    摘要翻译： 本发明鉴定了P-选择蛋白作为止血调节剂。 因此，本发明涉及用于鉴定和使用P-选择蛋白活性的调节剂作为止血调节剂的方法。 本发明还涉及用于诊断和治疗止血障碍的方法和组合物，包括但不限于出血性疾病和血栓形成障碍。 本发明描述了用于各种止血条件的诊断评估和预后的方法，以及用于鉴定表现出对这些病症倾向的受试者。 此外，本发明提供了用于诊断监测临床评估用于治疗止血或血管疾病以及用于监测化合物在临床试验中的功效的患者的诊断监测方法。

    Methods of treating hemophilia or von willebrand disease with p-selectin
    4.
    发明授权
    Methods of treating hemophilia or von willebrand disease with p-selectin 失效
    用p-选择素治疗血友病或血液血友病病毒的方法

    公开(公告)号：US07387777B2

    公开(公告)日：2008-06-17

    申请号：US10782456

    申请日：2004-02-19

    申请人： Denisa D. Wagner ,  Patrick Andre ,  Daqing W. Hartwell ,  Ingrid Hrachovinova

    发明人： Denisa D. Wagner ,  Patrick Andre ,  Daqing W. Hartwell ,  Ingrid Hrachovinova

    IPC分类号： A61K35/12 ,  C07K14/435

    CPC分类号： G01N33/86 ,  A61K38/178 ,  A61K48/00 ,  C07K2319/30 ,  G01N2333/70564

    摘要： The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity as modulators of hemostasis. The invention also relates to methods and compositions for the diagnosis and treatment of hemostatic disorders, including, but not limited to, hemorrhagic disorders and thrombotic disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hemostatic conditions, and for the identification of subjects exhibiting a predisposition to such conditions. In addition, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of a hemostatic or vascular disorders, and for monitoring the efficacy of compounds in clinical trials.

    摘要翻译： 本发明鉴定了P-选择蛋白作为止血调节剂。 因此，本发明涉及用于鉴定和使用P-选择蛋白活性的调节剂作为止血调节剂的方法。 本发明还涉及用于诊断和治疗止血障碍的方法和组合物，包括但不限于出血性疾病和血栓形成障碍。 本发明描述了用于各种止血条件的诊断评估和预后的方法，以及用于鉴定表现出对这些病症倾向的受试者。 此外，本发明提供了用于诊断监测临床评估用于治疗止血或血管疾病以及用于监测化合物在临床试验中的功效的患者的诊断监测方法。

    Method of inhibiting PADGEM-mediated or ELAM-1-mediated leukocyte adhesion using an inhibitor comprising a Le.sup.x core component
    7.
    发明授权
    Method of inhibiting PADGEM-mediated or ELAM-1-mediated leukocyte adhesion using an inhibitor comprising a Le.sup.x core component 失效
    使用包含Lex核心组分的抑制剂抑制PADGEM介导的或ELAM-1介导的白细胞粘附的方法

    公开(公告)号：US5807745A

    公开(公告)日：1998-09-15

    申请号：US379080

    申请日：1995-01-26

    申请人： Bruce Furie ,  Barbara C. Furie ,  Eric Larsen ,  Theresa Palabrica ,  Susan A. Sajer ,  Denisa D. Wagner

    发明人： Bruce Furie ,  Barbara C. Furie ,  Eric Larsen ,  Theresa Palabrica ,  Susan A. Sajer ,  Denisa D. Wagner

    IPC分类号： C07K14/705 ,  C07K16/28 ,  C12N5/00 ,  C12N5/06

    CPC分类号： C07K14/70564 ,  C07K16/2896

    摘要： The present invention relates to a method of inhibiting (reducing or preventing) the interaction of a cell which bears a surface molecule that interacts with a ligand comprising a Le.sup.x core with its target ligand by contacting the cell with an inhibitor comprising a Lewis x (Le.sup.x) core. The invention further relates to a method of inhibiting (reducing or preventing) the interaction or adhesion of endothelial cells and/or platelets with leukocytes (i.e., white blood cells), especially with nonlymphocytic leukocytes such as neutrophils and monocytes, by contacting the endothelial cells and/or platelets with an inhibitor comprising a Le.sup.x core under conditions whereby adhesion is inhibited.

    摘要翻译： 本发明涉及通过使细胞与包含Lewis x（Lex）的抑制剂接触来抑制（减少或预防）包含与包含Lex核心的配体与其靶配体相互作用的表面分子的细胞的相互作用的方法 ）核心。 本发明进一步涉及通过使内皮细胞接触来抑制（减少或预防）内皮细胞和/或血小板与白细胞（即白细胞）的相互作用或粘附，特别是与非淋巴细胞性白细胞如嗜中性粒细胞和单核细胞的相互作用或粘附的方法 和/或具有抑制剂的血小板，其中粘合被抑制的条件下。