公开(公告)号：US06635720B1

公开(公告)日：2003-10-21

申请号：US09913050

申请日：2002-01-24

申请人： Donald A. Tomalia ,  Srinivas Uppuluri ,  Douglas R. Swanson ,  Herbert M. Brothers, II

发明人： Donald A. Tomalia ,  Srinivas Uppuluri ,  Douglas R. Swanson ,  Herbert M. Brothers, II

IPC分类号： C08L7700

CPC分类号： C08G83/003 ,  C08G69/02 ,  C08G69/04 ,  C08G69/48 ,  Y10S424/16 ,  Y10S977/754 ,  Y10S977/788 ,  Y10S977/835

摘要： Core-shell tecto(dendrimers) useful in biomedicine, pharmaceuticals, personal care products, and in other ways analogous to the known uses for dendrimers, hypercomb branched polymers, and other dendritic polymers are the reaction product of a core dendritic polymer molecule having a plurality of terminal functional groups of a first type which are not reactive with each other, and a plurality of shell dendritic polymer molecules having a plurality of terminal functional groups of a second type which are not reactive with each other, but which are reactive with the terminal functional groups of the first type. Each of the shell dendritic polymer molecules is chemically bonded to the core dendritic polymer molecule by a reaction of at least one of the terminal functional groups of the second type with at least one of the terminal functional groups of the first type.

摘要翻译： 可用于生物医学，药物，个人护理产品的核壳结构（树枝状大分子），以及类似于已知用于树枝状大分子，超支化支化聚合物和其它树枝状聚合物的其它方式是具有多个核心树枝状聚合物分子的反应产物 不具有反应性的第一种类型的末端官能团，以及具有多个彼此不反应但与末端反应的第二类型的末端官能团的多个壳状树枝状聚合物分子 第一类功能组。 每个壳树枝状聚合物分子通过第二类型的至少一个末端官能团与至少一个第一类型的末端官能团的反应与核心树枝状聚合物分子化学键合。