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1.发明授权Use of the ornithine transcarbamylase (OTC), as a marker for diagnosing brain damages 有权使用鸟氨酸转氨甲酰酶（OTC）作为诊断脑损伤的标志物公开(公告)号：US08114624B2
公开(公告)日：2012-02-14
申请号：US12226413
申请日：2007-04-18
IPC分类号： C12Q1/40 , G01N33/53 , G01N33/542 , G01N33/537 , G01N33/566
CPC分类号： C07K16/40 , A01K2217/05 , A01K2267/0312 , C12N2830/002 , C12N2830/003 , C12N2830/008 , C12Q1/6883 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N2333/91034 , G01N2800/2821
摘要： The present invention pertains to the domain of brain diseases, and provides novel markers and methods for diagnosing a brain alteration in an individual, especially in patients suffering from neurodegenerative diseases such as Alzheimer's disease. The present invention also provides tools for evaluating the probability, for an individual, of developing the disease, as well as a target for identifying new drugs for treating neurodegenerative diseases such as Alzheimer's disease. In particular, the invention provides a genetic marker based on combination of two single nucleotide polymorphism, at positions −389 and −241 of the ornithine transcarbamylase (OTC) gene.
摘要翻译： 本发明涉及脑疾病的领域，并且提供了用于诊断个体中脑部改变的新型标志物和方法，特别是在患有神经变性疾病如阿尔茨海默病的患者中。 本发明还提供了用于评估个体发展疾病的可能性的工具，以及用于鉴定用于治疗神经变性疾病如阿尔茨海默氏病的新药物的靶标。 特别地，本发明提供了基于两个单核苷酸多态性在鸟氨酸转氨甲酰酶（OTC）基因的位置-389和-241的组合的遗传标记。
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2.发明申请Use of the Ornithine Transcarbamylase (OTC), as a Marker for Diagnosing Brain Damages 有权使用鸟氨酸转氨酶（OTC）作为诊断脑损伤的标记物公开(公告)号：US20090178152A1
公开(公告)日：2009-07-09
申请号：US12226413
申请日：2007-04-18
IPC分类号： A01K67/027 , C12Q1/48 , G01N33/573 , C12Q1/68
CPC分类号： C07K16/40 , A01K2217/05 , A01K2267/0312 , C12N2830/002 , C12N2830/003 , C12N2830/008 , C12Q1/6883 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N2333/91034 , G01N2800/2821
摘要： The present invention pertains to the domain of brain diseases, and provides novel markers and methods for diagnosing a brain alteration in an individual, especially in patients suffering from neurodegenerative diseases such as Alzheimer's disease. The present invention also provides tools for evaluating the probability, for an individual, of developing the disease, as well as a target for identifying new drugs for treating neurodegenerative diseases such as Alzheimer's disease. In particular, the invention provides a genetic marker based on combination of two single nucleotide polymorphism, at positions −389 and −241 of the ornithine transcarbamylase (OTC) gene.
摘要翻译： 本发明涉及脑疾病的领域，并且提供了用于诊断个体中脑部改变的新型标志物和方法，特别是在患有神经变性疾病如阿尔茨海默病的患者中。 本发明还提供了用于评估个体发展疾病的可能性的工具，以及用于鉴定用于治疗神经变性疾病如阿尔茨海默氏病的新药物的靶标。 特别地，本发明提供了基于两个单核苷酸多态性在鸟氨酸转氨甲酰酶（OTC）基因的位置-389和-241的组合的遗传标记。
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