公开(公告)号：US08815519B2

公开(公告)日：2014-08-26

申请号：US12520718

申请日：2007-12-12

申请人： Jesper Eugen-Olsen ,  Steen B. Haugaard ,  Ove Andersen

发明人： Jesper Eugen-Olsen ,  Steen B. Haugaard ,  Ove Andersen

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2333/70596 ,  G01N2800/04 ,  G01N2800/52 ,  G01N2800/7095

摘要： The invention concerns a marker for low-grade inflammation and metabolic syndrome (MS) and MS-related diseases and/or low-grade inflammation-related diseases such as cardiovasculardisease, ischemic heart disease and type 2 diabetes. More particularly it concerns the measurement of the concentration of soluble urokinase plasminogen activator receptor (suPAR) in human biological fluids (sputum, cystic fluid, ascites, serum, plasma, urine) as a tool of diagnosing and/or prognosticating low-grade inflammation and metabolic syndrome and the risk of development of the related diseases such as cancer, cardiovascular disease, ischemic heart disease and type 2 diabetes.

摘要翻译： 本发明涉及低度炎症和代谢综合征（MS）和MS相关疾病和/或低度炎症相关疾病如心血管疾病，缺血性心脏病和2型糖尿病的标志物。 更具体地说，它涉及测量人体生物液体（痰液，囊性液体，腹水，血清，血浆，尿液）中可溶性尿激酶纤溶酶原激活物受体（suPAR）的浓度，作为诊断和/或预测低度炎症的工具， 代谢综合征和相关疾病如癌症，心血管疾病，缺血性心脏病和2型糖尿病发展的风险。

公开(公告)号：US20100098705A1

公开(公告)日：2010-04-22

申请号：US12520718

申请日：2007-12-12

申请人： Jesper Eugen-Olsen ,  Steen B. Haugaard ,  Ove Andersen

发明人： Jesper Eugen-Olsen ,  Steen B. Haugaard ,  Ove Andersen

IPC分类号： A61K39/395 ,  C12Q1/02 ,  G01N33/53 ,  C12Q1/54 ,  C12Q1/60 ,  G06N5/02

CPC分类号： G01N33/6893 ,  G01N2333/70596 ,  G01N2800/04 ,  G01N2800/52 ,  G01N2800/7095

摘要： The invention concerns a marker for low-grade inflammation and metabolic syndrome (MS) and MS-related diseases and/or low-grade inflammation-related diseases such as cardiovasculardisease, ischemic heart disease and type 2 diabetes. More particularly it concerns the measurement of the concentration of soluble urokinase plasminogen activator receptor (suPAR) in human biological fluids (sputum, cystic fluid, ascites, serum, plasma, urine) as a tool of diagnosing and/or prognosticating low-grade inflammation and metabolic syndrome and the risk of development of the related diseases such as cancer, cardiovascular disease, ischemic heart disease and type 2 diabetes.

摘要翻译： 本发明涉及低度炎症和代谢综合征（MS）和MS相关疾病和/或低度炎症相关疾病如心血管疾病，缺血性心脏病和2型糖尿病的标志物。 更具体地说，它涉及测量人体生物液体（痰液，囊性液体，腹水，血清，血浆，尿液）中可溶性尿激酶纤溶酶原激活物受体（suPAR）的浓度，作为诊断和/或预测低度炎症的工具， 代谢综合征和相关疾病如癌症，心血管疾病，缺血性心脏病和2型糖尿病发展的风险。