FUSION PROTEINS COMPRISING HIV-1 TAT AND/OR NEF PROTEINS
    2.
    发明申请
    FUSION PROTEINS COMPRISING HIV-1 TAT AND/OR NEF PROTEINS 审中-公开
    包含HIV-1 TAT和/或NEF蛋白的融合蛋白

    公开(公告)号:US20080089902A1

    公开(公告)日:2008-04-17

    申请号:US11866146

    申请日:2007-10-02

    IPC分类号: A61K39/21 A61P31/18

    摘要: The invention provides (a) an HIV Tat protein or derivative thereof linked to either (i) a fusion partner or (ii) an HIV Nef protein or derivative thereof; or (b) an HIV Nef protein or derivative thereof linked to either (i) a fusion partner or (ii) an HIV Tat protein or derivative thereof; or (c) an HIV Nef protein or derivative thereof linked to an HIV Tat protein or derivative thereof and a fusion partner. The invention further provides for a nucleic acid encoding such a protein and a host cell, such as Pichia Pastoris, transformed with the aforementioned nucleic acid.

    摘要翻译: 本发明提供(a)与(i)融合伴侣或(ii)HIV Nef蛋白或其衍生物连接的HIV Tat蛋白或其衍生物; 或(b)与(i)融合伴侣或(ii)HIV Tat蛋白或其衍生物连接的HIV Nef蛋白或其衍生物; 或(c)与HIV Tat蛋白或其衍生物和融合配偶体连接的HIV Nef蛋白或其衍生物。 本发明进一步提供了用上述核酸转化的编码这种蛋白质和宿主细胞如毕赤酵母的核酸。