公开(公告)号：US6039977A

公开(公告)日：2000-03-21

申请号：US987372

申请日：1997-12-09

申请人： Subramanian S. Venkatraman ,  Thomas O. Murdock ,  Stephanus Pudjijanto

发明人： Subramanian S. Venkatraman ,  Thomas O. Murdock ,  Stephanus Pudjijanto

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/16 ,  A61K47/32 ,  A61K9/10 ,  A61M37/00

CPC分类号： A61K9/0009 ,  A61K47/32 ,  A61K9/0014 ,  Y10S514/944

摘要： Pharmaceutical hydrogel formulations containing polyvinyl alcohol are provided. The formulations may serve as rug reservoirs in electrotransport drug delivery systems or passive transdermal systems, or they may be used in a variety of other types of dosage forms, e.g., capsules, suppositories, aerosols, and the like. With these formulations, there is virtually no syneresis encountered upon long term storage, an advantage that derives from selecting the quantity of polyvinyl alcohol in the gel to correspond to the polymer's degree of hydrolysis.

摘要翻译： 提供含有聚乙烯醇的药物水凝胶制剂。 制剂可以用作电转运药物递送系统或被动透皮系统中的地毯储存器，或者它们可以用于各种其它类型的剂型，例如胶囊，栓剂，气溶胶等。 使用这些制剂，长期储存时几乎没有出现脱水收缩，这是从凝胶中选择聚乙烯醇的量来对应于聚合物水解度的优点。

公开(公告)号：US06275728B1

公开(公告)日：2001-08-14

申请号：US09467084

申请日：1999-12-10

申请人： Subramanian S. Venkatraman ,  Eli J. Goldman ,  Lothar W. Kleiner ,  Stephanus Pudjijanto

发明人： Subramanian S. Venkatraman ,  Eli J. Goldman ,  Lothar W. Kleiner ,  Stephanus Pudjijanto

IPC分类号： A61N130

CPC分类号： A61N1/0448

摘要： The present invention relates to hydratable drug reservoir films for electrotransport drug delivery devices and to electrotransport drug delivery systems containing the hydratable drug reservoirs and to methods for manufacturing and using such systems. The hydratable reservoir films according to this invention are easily manufacturable and rapidly imbibe water and/or drug solution with good water retention and stability.

摘要翻译： 本发明涉及用于电转运药物递送装置的可水合药物储存膜以及含有可水合药物储存器的电输送药物递送系统以及用于制造和使用这些系统的方法。 根据本发明的可水合储液膜易于制造并且快速吸收具有良好保水性和稳定性的水和/或药物溶液。