公开(公告)号：US20060024806A1

公开(公告)日：2006-02-02

申请号：US11175689

申请日：2005-07-07

申请人： Timothy Stinear ,  Stewart Cole ,  Peter Leadlay ,  Pamela Small ,  Paul Johnson ,  Grant Jenkin ,  John Davies ,  Stephen Haydock

发明人： Timothy Stinear ,  Stewart Cole ,  Peter Leadlay ,  Pamela Small ,  Paul Johnson ,  Grant Jenkin ,  John Davies ,  Stephen Haydock

IPC分类号： C07H21/04 ,  C12N9/02

CPC分类号： C12N15/52

摘要： The present invention relates to Mycobacterium ulcerans virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and sufficient for mycolactone biosynthesis. More particularly this invention is directed to novel purified or isolated polypeptides, the polynucleotides encoding such polypeptides, processes for production of such polypeptides, antibodies generated against these polypeptides, the use of such polynucleotides and polypeptides in Diagnostic methods, kits, vaccines, therapy and for the production of mycolactone derivatives or novel polyketides by combinatorial synthesis.

摘要翻译： 本发明涉及溃疡分枝杆菌毒力质粒pMUM001，特别涉及由该质粒携带的编码聚酮内酯合成酶（PKS）和聚酮化合物修饰酶的基因簇，其对于霉酚酸内酯生物合成是必需和足够的。 更具体地说，本发明涉及新的纯化或分离的多肽，编码这些多肽的多核苷酸，产生此类多肽的方法，针对这些多肽产生的抗体，在诊断方法，试剂盒，疫苗，治疗中用于此类多核苷酸和多肽 通过组合合成生产莫考内酯衍生物或新型聚酮化合物。

公开(公告)号：US20070106820A1

公开(公告)日：2007-05-10

申请号：US11525253

申请日：2006-09-21

申请人： Stephen Haydock

发明人： Stephen Haydock

IPC分类号： G06F3/00

CPC分类号： G06F21/85 ,  G06F12/1408

摘要： An integrated circuit, method of making an integrated circuit and method of addressing peripherals of an integrated circuit are disclosed for preventing copied software from running on unauthorised hardware. A permanent key is embedded in the integrated circuit and used to transform a peripheral access address output by a processor of the integrated circuit. The transformed access address is supplied to a peripheral address decoder f the integrated circuit, which allows the processor to access a corresponding peripheral. A method of supplying integrated circuits to prevent copied software from running on unauthorized hardware is also disclosed.

摘要翻译： 公开了集成电路，制造集成电路的方法和寻址集成电路的外围设备的方法，以防止复制的软件在未经授权的硬件上运行。 永久性密钥嵌入在集成电路中，用于变换由集成电路的处理器输出的外设访问地址。 变换的访问地址被提供给集成电路的外围地址解码器，这允许处理器访问相应的外围设备。 还公开了提供集成电路以防止复制的软件在未经授权的硬件上运行的方法。