公开(公告)号：US20060275309A1

公开(公告)日：2006-12-07

申请号：US10537852

申请日：2003-12-12

Applicant: Steven Boneham ,  Jonathan Ball

Inventor： Steven Boneham ,  Jonathan Ball

IPC: A61K39/42 ,  C12P21/04 ,  C12Q1/70 ,  C07K14/16 ,  C07K16/10 ,  C12N5/06

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/1063 ,  C07K2317/34 ,  C12N15/62 ,  C12N2740/16122

Abstract: Partially occluded and/or multimeric presentations of peptides mimic the epitopes recognised by antibodies capable of neutralising diverse clinical isolates of the human immunodeficiency virus type 1 (HIV-1). By “partially occluded” is meant a presentation that has a three-dimensional structure (probably a barrel/cylindrical/helical shape) generated by inter-chain disulphide bridging or other means that has internally, at or near its base, the epitope that is recognised by the neutralising antibody; i.e. a partially occluded presentation is a three-dimensional presentation of one or more neutralising epitopes such that the epitope is located in a pocket or cleft. Such presentations are better at eliciting antibodies that have the neutralising phenotype, and may be used as vaccines or to produce antibodies for the prevention or treatment of HIV-1 infection.

Abstract translation: 肽的部分封闭和/或多聚体呈递模拟由能够中和人类免疫缺陷病毒1型（HIV-1）的多种临床分离物的抗体识别的表位。 “部分闭塞”是指具有通过链间二硫键桥接产生的三维结构（可能是桶/圆柱形/螺旋形状）或其内部在其碱基附近或其附近的其它方式的表达， 被中和抗体识别; 即部分闭塞的呈现是一个或多个中和表位的三维呈现，使得表位位于口袋或裂口中。 这样的表现更好地引发具有中和表型的抗体，并且可以用作疫苗或产生用于预防或治疗HIV-1感染的抗体。