公开(公告)号：US08641683B2

公开(公告)日：2014-02-04

申请号：US13407430

申请日：2012-02-28

Applicant: Kristian Glejbol ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

Inventor： Kristian Glejbol ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

IPC: A61M5/00

CPC classification number: A61M5/3158 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31556 ,  A61M5/31558 ,  A61M5/3156 ,  A61M5/31561 ,  A61M5/31573 ,  A61M5/31575 ,  A61M5/31585 ,  A61M2005/3152

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract translation: 用于从药筒注射设定剂量的药物的注射装置具有在剂量设定操作期间沿着螺纹活塞杆拧紧的螺母。 通过旋转剂量设定构件将螺母沿着活塞杆拧紧。 旋转联接机构包括作为轴向位移的函数旋转的可轴向移动的联接构件。 在剂量设定期间，允许螺母相对于联接构件旋转。 在注射期间，联接构件旋转地锁定到螺母。 这提供了剂量设定和注射机制，其中螺母构件在剂量设定期间和注射期间都旋转。

公开(公告)号：US08197450B2

公开(公告)日：2012-06-12

申请号：US12571721

申请日：2009-10-01

Applicant: Kristian Glejbol ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

Inventor： Kristian Glejbol ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

IPC: A61M5/00

CPC classification number: A61M5/3158 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31556 ,  A61M5/31558 ,  A61M5/3156 ,  A61M5/31561 ,  A61M5/31573 ,  A61M5/31575 ,  A61M5/31585 ,  A61M2005/3152

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract translation: 用于从药筒注射设定剂量的药物的注射装置具有在剂量设定操作期间沿着螺纹活塞杆拧紧的螺母。 通过旋转剂量设定构件将螺母沿着活塞杆拧紧。 旋转联接机构包括作为轴向位移的函数旋转的可轴向移动的联接构件。 在剂量设定期间，允许螺母相对于联接构件旋转。 在注射期间，联接构件旋转地锁定到螺母。 这提供了剂量设定和注射机制，其中螺母构件在剂量设定期间和注射期间都旋转。

公开(公告)号：US5928202A

公开(公告)日：1999-07-27

申请号：US178104

申请日：1998-10-23

Applicant: Steven Linnebjerg

Inventor： Steven Linnebjerg

IPC: A61M5/315

CPC classification number: A61M5/31511 ,  A61M2005/31516 ,  A61M5/31515

Abstract: The hollow cylindrical syringe body has a channel of uniform diameter. A fluid port is situated at one end. The other end defines a funnel-like opening with a diameter greater than that of the channel. A piston is moved along the channel by the end of a push rod which is received through the channel opening. A ball on the push rod lodges in a socket in the piston as the rod pushes the piston toward the port. The socket is formed of resilient fingers which are held by the channel wall in position to retain the ball in the socket, such that the piston can be moved along the channel to load the syringe. When the socket aligns with the funnel-like opening of the channel, the socket fingers spread apart to release the ball from the socket, permitting the push rod to be removed from the loaded syringe.

Abstract translation: 中空圆柱形注射器主体具有均匀直径的通道。 流体端口位于一端。 另一端限定了直径大于通道直径的漏斗状开口。 活塞通过通过通道开口接收的推杆的端部沿着通道移动。 当杆推动活塞朝向端口时，推杆上的球倒伏在活塞的插座中。 插座由弹性指状物形成，其由通道壁保持在适当位置以将球保持在插座中，使得活塞可以沿着通道移动以加载注射器。 当插座对准通道的漏斗状开口时，插口指状物分开以将球从插座释放，从而允许从装载的注射器移除推杆。

公开(公告)号：US09186465B2

公开(公告)日：2015-11-17

申请号：US13126378

申请日：2009-11-05

Applicant: Bjarke Dupont Jørgensen ,  Jan Lindhardt Petersen ,  Steven Linnebjerg ,  Henrik Groth Ludvigsen ,  Michael Ejstrup Hansen ,  Erik Beyerholm ,  Ramin Nateghi Elahi

Inventor： Bjarke Dupont Jørgensen ,  Jan Lindhardt Petersen ,  Steven Linnebjerg ,  Henrik Groth Ludvigsen ,  Michael Ejstrup Hansen ,  Erik Beyerholm ,  Ramin Nateghi Elahi

IPC: A61M5/31 ,  A61M5/315 ,  A61M5/24

CPC classification number: A61M5/31551 ,  A61M5/24 ,  A61M5/31535 ,  A61M5/31543 ,  A61M5/31558 ,  A61M5/3157 ,  A61M5/31575 ,  A61M5/3158 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2005/3152 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/8206 ,  G06F19/00

Abstract: The present invention relates to electronically assisted drug delivery devices (100). The drug delivery device may include a Gray code type detector for sensing dosage data, wherein the detector comprises a code track consisting of a sequence of alternating markings and a plurality of detectors that are mutually spaced in a direction extending along the code track. The drug delivery device may also include a dosage selector (260) which is moved in a proximal direction upon dose setting and in a distal direction upon dose injection, where the dosage selector is latched in the end of dose position by a latching element, the latching element actuating an end of dose switch for signalling the end of dose state. The drug delivery device may also incorporate power-management arrangements which effectively minimizes power consumption for the incorporated electronic circuitry.

Abstract translation: 本发明涉及电子辅助药物输送装置（100）。 药物递送装置可以包括用于感测剂量数据的格雷码型检测器，其中检测器包括由沿着码轨道延伸的方向相互间隔开的交替标记序列和多个检测器组成的码轨道。 药物递送装置还可以包括剂量选择器（260），其在剂量设定时沿近端方向移动，并且在剂量注射时在远侧方向上移动，其中剂量选择器通过闭锁元件在剂量位置结束时锁定， 闭锁元件致动剂量开关的末端，用于指示剂量状态的结束。 药物递送装置还可以包括电力管理布置，其有效地最小化所结合的电子电路的功率消耗。

公开(公告)号：US20120157932A1

公开(公告)日：2012-06-21

申请号：US13407430

申请日：2012-02-28

Applicant: KRISTIAN GLEJBOL ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

Inventor： KRISTIAN GLEJBOL ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

IPC: A61M5/315

CPC classification number: A61M5/3158 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31556 ,  A61M5/31558 ,  A61M5/3156 ,  A61M5/31561 ,  A61M5/31573 ,  A61M5/31575 ,  A61M5/31585 ,  A61M2005/3152

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract translation: 用于从药筒注射设定剂量的药物的注射装置具有在剂量设定操作期间沿着螺纹活塞杆拧紧的螺母。 通过旋转剂量设定构件将螺母沿着活塞杆拧紧。 旋转联接机构包括作为轴向位移的函数旋转的可轴向移动的联接构件。 在剂量设定期间，允许螺母相对于联接构件旋转。 在注射期间，联接构件旋转地锁定到螺母。 这提供了剂量设定和注射机制，其中螺母构件在剂量设定期间和注射期间都旋转。

公开(公告)号：US20100016806A1

公开(公告)日：2010-01-21

申请号：US12571721

申请日：2009-10-01

Applicant: KRISTIAN GLEJBOL ,  Steven Linnebjerg ,  Claus Schmidt Møller ,  Michael Ejstrup Hansen

Inventor： KRISTIAN GLEJBOL ,  Steven Linnebjerg ,  Claus Schmidt Møller ,  Michael Ejstrup Hansen

IPC: A61M5/315

CPC classification number: A61M5/3158 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31556 ,  A61M5/31558 ,  A61M5/3156 ,  A61M5/31561 ,  A61M5/31573 ,  A61M5/31575 ,  A61M5/31585 ,  A61M2005/3152

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract translation: 用于从药筒注射设定剂量的药物的注射装置具有在剂量设定操作期间沿着螺纹活塞杆拧紧的螺母。 通过旋转剂量设定构件将螺母沿着活塞杆拧紧。 旋转联接机构包括作为轴向位移的函数旋转的可轴向移动的联接构件。 在剂量设定期间，允许螺母相对于联接构件旋转。 在注射期间，联接构件旋转地锁定到螺母。 这提供了剂量设定和注射机制，其中螺母构件在剂量设定期间和注射期间都旋转。

公开(公告)号：US20110270214A1

公开(公告)日：2011-11-03

申请号：US13126378

申请日：2009-11-05

Applicant: Bjarke Dupont Jørgensen ,  Jan Lindhardt Petersen ,  Steven Linnebjerg ,  Henrik Groth Ludvigsen ,  Michael Ejstrup Hansen ,  Erik Beyerholm ,  Ramin Nateghi Elahi ,  Niels Pryds Rolsted ,  Jens Holme

Inventor： Bjarke Dupont Jørgensen ,  Jan Lindhardt Petersen ,  Steven Linnebjerg ,  Henrik Groth Ludvigsen ,  Michael Ejstrup Hansen ,  Erik Beyerholm ,  Ramin Nateghi Elahi ,  Niels Pryds Rolsted ,  Jens Holme

IPC: A61M5/31

CPC classification number: A61M5/31551 ,  A61M5/24 ,  A61M5/31535 ,  A61M5/31543 ,  A61M5/31558 ,  A61M5/3157 ,  A61M5/31575 ,  A61M5/3158 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2005/3152 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/8206 ,  G06F19/00

Abstract: The present invention relates to electronically assisted drug delivery devices (100). The drug delivery device may include a Gray code type detector for sensing dosage data, wherein the detector comprises a code track consisting of a sequence of alternating markings and a plurality of detectors that are mutually spaced in a direction extending along the code track. The drug delivery device may also include a dosage selector (260) which is moved in a proximal direction upon dose setting and in a distal direction upon dose injection, where the dosage selector is latched in the end of dose position by a latching element, the latching element actuating an end of dose switch for signalling the end of dose state. The drug delivery device may also incorporate power-management arrangements which effectively minimizes power consumption for the incorporated electronic circuitry.

Abstract translation: 本发明涉及电子辅助药物输送装置（100）。 药物递送装置可以包括用于感测剂量数据的格雷码型检测器，其中检测器包括由沿着码轨道延伸的方向相互间隔开的交替标记序列和多个检测器组成的码轨道。 药物递送装置还可以包括剂量选择器（260），其在剂量设定时沿近端方向移动，并且在剂量注射时在远端方向移动，其中剂量选择器通过闭锁元件在剂量位置结束时锁定， 闭锁元件致动剂量开关的末端，用于指示剂量状态的结束。 药物递送装置还可以包括电力管理布置，其有效地最小化所结合的电子电路的功率消耗。

公开(公告)号：US20090043264A1

公开(公告)日：2009-02-12

申请号：US11911871

申请日：2006-04-21

Applicant: Kristian Glejbol ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

Inventor： Kristian Glejbol ,  Steven Linnebjerg ,  Claus Schmidt Moller ,  Michael Ejstrup Hansen

IPC: A61M5/315

CPC classification number: A61M5/3158 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31556 ,  A61M5/31558 ,  A61M5/3156 ,  A61M5/31561 ,  A61M5/31573 ,  A61M5/31575 ,  A61M5/31585 ,  A61M2005/3152

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut (13) that is screwed up along a threaded piston rod (4) during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member (17. A rotational coupling mechanism includes an axially displaceable coupling member (25) which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract translation: 用于从药筒注射设定剂量的药物的注射装置具有在剂量设定操作期间沿着螺纹活塞杆（4）拧紧的螺母（13）。 通过旋转剂量调节构件（17）将螺母沿着活塞杆拧紧。旋转联接机构包括作为轴向位移的函数旋转的可轴向移动的联接构件（25）。在剂量设定期间，允许螺母旋转 在注射期间，联接构件旋转地锁定到螺母上，这提供了剂量设定和注射机构，其中螺母构件在剂量设定期间和注射期间都旋转。

公开(公告)号：US06454786B1

公开(公告)日：2002-09-24

申请号：US08970291

申请日：1997-11-14

Applicant: Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

Inventor： Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

IPC: A61B1708

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

Abstract: Novel methods and devices which provide enhanced mixing and application of two liquid components to form a biomaterial with minimized aerosols is achieved using air flow rates below about 1.25 liters/minute in combination with a ratio of air flow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the air flow is below about 1 liter/minute and the ratio of air flow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention are novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip or nozzle, novel spray tips and biomaterial applicators and methods for making such applicators.

Abstract translation: 使用低于约1.25升/分钟的空气流速与空气流量与总液体流量的比例为约150:1实现提供两种液体组分的增强混合和应用以形成具有最小化的气溶胶的生物材料的新方法和装置。 1到1500：1。 优选地，气流低于约1升/分钟，并且空气流与总液体流量的比率为约200:1至约1200:1。 这些参数非常适用于喷雾施用形成外科密封剂的组分，例如纤维蛋白封闭剂。 本发明的另一部分是用于生物材料的新型应用方法，例如手术密封剂，液体流速低于1.9ml /分钟的组分，涉及将这些组分混合在喷嘴或喷嘴的出口表面上的新方法，新型喷雾 提示和生物材料施加器以及制造这种涂敷器的方法。

公开(公告)号：US06206905B1

公开(公告)日：2001-03-27

申请号：US09358078

申请日：1999-07-21

Applicant: Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

Inventor： Niels Erik Holm ,  Steven Linnebjerg ,  Richard Cornwell

IPC: A61B1708

CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  A61M35/00 ,  B05B7/08 ,  B05B7/0876

Abstract: Novel methods and devices which provide enhanced mixing and application of two liquid components to form a biomaterial with minimized aerosols is achieved using air flow rates below about 1.25 liters/minute in combination with a ratio of air flow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the air flow is below about 1 liter/minute and the ratio of air flow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention are novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip or nozzle, novel spray tips and biomaterial applicators and methods for making such applicators.

Abstract translation: 使用空气流速低于约1.25升/分钟，结合空气流与总液体流量的比例为约150:1，提供增强混合和应用两种液体组分以形成具有最小化气溶胶的生物材料的新方法和装置。 1到1500：1。 优选地，气流低于约1升/分钟，并且空气流与总液体流量的比率为约200:1至约1200:1。 这些参数非常适用于喷雾施用形成外科密封剂的组分，例如纤维蛋白封闭剂。 本发明的另一部分是用于生物材料的新型应用方法，例如手术密封剂，液体流速低于1.9ml /分钟的组分，涉及将这些组分混合在喷嘴或喷嘴的出口表面上的新方法，新型喷雾 提示和生物材料施加器以及制造这种涂敷器的方法。