公开(公告)号：US6124299A

公开(公告)日：2000-09-26

申请号：US28085

申请日：1998-02-23

Applicant: Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. McKernan ,  Emma E. Moore

Inventor： Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. McKernan ,  Emma E. Moore

IPC: C07D295/08 ,  A61K31/495 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D295/096 ,  C07D295/20 ,  C07D295/215 ,  A61K31/415 ,  A61K31/55

CPC classification number: C07D295/096 ,  A61K31/495 ,  C07D295/215

Abstract: Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.

公开(公告)号：US06395740B1

公开(公告)日：2002-05-28

申请号：US09616695

申请日：2000-07-14

Applicant: Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. Mckernan ,  Emma E. Moore

Inventor： Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. Mckernan ,  Emma E. Moore

IPC: A61K31495

CPC classification number: C07D295/096 ,  A61K31/495 ,  C07D295/215

Abstract: Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.

Abstract translation: 描述了作为降钙素模拟物的化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物中包括取代的哌嗪。 本发明的降钙素模拟物也可用于文库和用于测定降钙素受体活性的测定中。