公开(公告)号：US6124299A

公开(公告)日：2000-09-26

申请号：US28085

申请日：1998-02-23

申请人： Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. McKernan ,  Emma E. Moore

发明人： Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. McKernan ,  Emma E. Moore

IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D295/096 ,  C07D295/20 ,  C07D295/215 ,  A61K31/415 ,  A61K31/55

CPC分类号： C07D295/096 ,  A61K31/495 ,  C07D295/215

摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.

公开(公告)号：US06395740B1

公开(公告)日：2002-05-28

申请号：US09616695

申请日：2000-07-14

申请人： Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. Mckernan ,  Emma E. Moore

发明人： Nand Baindur ,  Virender Labroo ,  Steven Stroop ,  Stephanie Beigel ,  Theresa Martinez ,  Charles R. Petrie ,  Mark W. Orme ,  Patricia A. Mckernan ,  Emma E. Moore

IPC分类号： A61K31495

CPC分类号： C07D295/096 ,  A61K31/495 ,  C07D295/215

摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.

摘要翻译： 描述了作为降钙素模拟物的化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物中包括取代的哌嗪。 本发明的降钙素模拟物也可用于文库和用于测定降钙素受体活性的测定中。

公开(公告)号：US06255351B1

公开(公告)日：2001-07-03

申请号：US09410115

申请日：1999-09-30

申请人： Charles R. Petrie ,  Patricia A. McKernan ,  Emma E. Moore ,  John M. Ostresh ,  Jean-Philippe Meyer ,  Richard A. Houghten ,  Clemencia Pinilla

发明人： Charles R. Petrie ,  Patricia A. McKernan ,  Emma E. Moore ,  John M. Ostresh ,  Jean-Philippe Meyer ,  Richard A. Houghten ,  Clemencia Pinilla

IPC分类号： A61K3117

CPC分类号： C07C275/28 ,  C07D209/20 ,  Y10S514/878

摘要： Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.

摘要翻译： 描述了作为降钙素模拟物的二烷基脲化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物也可用于测定降钙素受体活性的测定中。

公开(公告)号：US06391917B1

公开(公告)日：2002-05-21

申请号：US09838726

申请日：2001-04-19

申请人： Charles R. Petrie ,  Patricia A. McKernan ,  Emma E. Moore ,  John M. Ostresh ,  Jean-Philippe Meyer ,  Richard A. Houghten ,  Clemencia Pinilla

发明人： Charles R. Petrie ,  Patricia A. McKernan ,  Emma E. Moore ,  John M. Ostresh ,  Jean-Philippe Meyer ,  Richard A. Houghten ,  Clemencia Pinilla

IPC分类号： A61K3117

CPC分类号： C07C275/28 ,  C07D209/20 ,  Y10S514/878

摘要： Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.

摘要翻译： 描述了作为降钙素模拟物的二烷基脲化合物。 这些化合物可用于治疗与骨吸收相关的疾病。 本发明的降钙素模拟物也可用于测定降钙素受体活性的测定中。

公开(公告)号：US06221913B1

公开(公告)日：2001-04-24

申请号：US09233893

申请日：1999-01-20

申请人： Charles R. Petrie ,  Patricia A. McKernan ,  Emma E. Moore ,  John M. Ostresh ,  Jean-Philippe Meyer ,  Richard A. Houghten ,  Clemencia Pinilla

发明人： Charles R. Petrie ,  Patricia A. McKernan ,  Emma E. Moore ,  John M. Ostresh ,  Jean-Philippe Meyer ,  Richard A. Houghten ,  Clemencia Pinilla

IPC分类号： A61K3117

CPC分类号： C07C275/28 ,  C07D209/20 ,  Y10S514/878

摘要： Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.

公开(公告)号：US5648219A

公开(公告)日：1997-07-15

申请号：US479882

申请日：1995-06-07

申请人： Vivian L. MacKay ,  Emma E. Moore

发明人： Vivian L. MacKay ,  Emma E. Moore

IPC分类号： C12N5/071 ,  C12N5/077 ,  C12N5/078 ,  C12N5/0784 ,  C12Q1/68 ,  C12N5/02 ,  C12N15/12 ,  C12Q1/02

CPC分类号： C12N5/0643 ,  C12N5/0639 ,  C12N2501/02 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2503/02 ,  C12N2510/00 ,  C12N2510/04 ,  C12N2517/02

摘要： The present invention provides an immature dendritic cell line derived from p53 growth suppressor gene deficient animals. The immature dendritic cell line may be induced to become an activated dendritic cell line that will stimulate T-cells to proliferate. The cell line is useful for presentation of antigens involved in autoimmune disease and analysis of peptides that produce a T-cell response.

摘要翻译： 本发明提供了源自p53生长抑制基因缺陷动物的未成熟树突状细胞系。 未成熟树突状细胞系可能被诱导成激活的树突状细胞系，其将刺激T细胞增殖。 细胞系可用于介导参与自身免疫性疾病的抗原和产生T细胞应答的肽的分析。

公开(公告)号：US5533836A

公开(公告)日：1996-07-09

申请号：US408331

申请日：1995-03-22

申请人： Emma E. Moore

发明人： Emma E. Moore

IPC分类号： A61K38/22 ,  A61K31/59 ,  A61K38/18 ,  A61P19/00 ,  A61P19/08 ,  A61P43/00 ,  C12N5/02 ,  C12N5/077 ,  C12N5/08

CPC分类号： C12N5/0654 ,  A61K38/1858 ,  C12N2500/38 ,  C12N2501/135 ,  Y10S514/878

摘要： Methods and compositions for stimulating the growth of osteoblasts are disclosed. A composition comprising platelet derived growth factor and vitamin D is applied to osteoblasts in an amount sufficient to stimulate their growth. The methods may be used to promote the growth of osteoblasts in vitro or to promote the healing of bone defects in vivo.

摘要翻译： 公开了刺激成骨细胞生长的方法和组合物。 包含血小板衍生生长因子和维生素D的组合物以足以刺激其生长的量施用于成骨细胞。 该方法可用于促进体外成骨细胞的生长或促进体内骨缺损的愈合。

公开(公告)号：US5674689A

公开(公告)日：1997-10-07

申请号：US454464

申请日：1995-05-30

申请人： Emma E. Moore ,  Paul O. Sheppard ,  Rolf E. Kuestner

发明人： Emma E. Moore ,  Paul O. Sheppard ,  Rolf E. Kuestner

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/72 ,  C07K16/26 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/566 ,  C07K17/00

CPC分类号： C07K14/72 ,  A61K38/00 ,  Y10S530/81

摘要： Human calcitonin receptors have been cloned, sequenced and expressed by recombinant means. The receptors and antibodies thereto may be used in screening systems to identify agonists and antagonists of human calcitonin receptors, thereby providing means for treating and preventing abnormal bone resorption, as well as in methods of diagnosis.

摘要翻译： 人类降钙素受体已被克隆，测序并通过重组手段表达。 其中的受体及其抗体可用于筛选系统以鉴定人降钙素受体的激动剂和拮抗剂，从而提供治疗和预防异常骨吸收的方法以及诊断方法。

公开(公告)号：US5622839A

公开(公告)日：1997-04-22

申请号：US453742

申请日：1995-05-30

申请人： Emma E. Moore ,  Paul O. Sheppard ,  Rolf E. Kuestner

发明人： Emma E. Moore ,  Paul O. Sheppard ,  Rolf E. Kuestner

IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/72 ,  C07K16/26 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K14/72 ,  A61K38/00 ,  Y10S530/81

摘要： Human calcitonin receptors have been cloned, sequenced and expressed by recombinant means. The receptors and antibodies thereto may be used in screening systems to identify agonists and antagonists of human calcitonin receptors, thereby providing means for treating and preventing abnormal bone resorption, as well as in methods of diagnosis.

摘要翻译： 人类降钙素受体已被克隆，测序并通过重组手段表达。 其中的受体及其抗体可用于筛选系统以鉴定人降钙素受体的激动剂和拮抗剂，从而提供治疗和预防异常骨吸收的方法以及诊断方法。

公开(公告)号：US5830682A

公开(公告)日：1998-11-03

申请号：US770895

申请日：1996-12-13

申请人： Emma E. Moore

发明人： Emma E. Moore

IPC分类号： C12N5/071 ,  C12N5/077 ,  C12N5/06 ,  C12Q1/02

CPC分类号： C12N5/0643 ,  C12N5/0639 ,  C12N5/0654 ,  C12N5/0657 ,  C12N5/0683 ,  C12N2501/02 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2503/02 ,  C12N2510/04 ,  C12N2517/02

摘要： All lines have been prepared from growth suppressor gene deficient animals. The cells include immortalized precursor cells and differentiated cells such as osteoclast precursors, osteoblast precursors, megakaryocytes, osteoclasts, osteoblasts, pancreatic .alpha.-cells, pancreatic .beta.-cells, pancreatic .delta.-cells, adipocytes, macrophages, chondrocytes, dendritic cells, hepatocytes, myocytes and prostatic cells. The cells are useful for constructing cDNA and protein libraries, screening agonists and antagonists of compounds and factors that affect metabolic pathways of specific cells and generating cell-specific antibodies.

摘要翻译： 所有的系都是由生长抑制基因缺陷动物制备的。 细胞包括永生化前体细胞和分化细胞如破骨细胞前体，成骨细胞前体，巨核细胞，破骨细胞，成骨细胞，胰腺α细胞，胰腺β-细胞，胰腺β-细胞，脂肪细胞，巨噬细胞，软骨细胞，树突状细胞，肝细胞，肌细胞 和前列腺细胞。 细胞可用于构建cDNA和蛋白质文库，筛选化合物的激动剂和拮抗剂以及影响特定细胞的代谢途径并产生细胞特异性抗体的因子。