公开(公告)号：US20090042188A1

公开(公告)日：2009-02-12

申请号：US11916199

申请日：2005-06-08

申请人： Inpyo Choi ,  SukRan Yoon ,  KeeNyung Lee ,  SunWook Kim ,  DaeYul Yoo

发明人： Inpyo Choi ,  SukRan Yoon ,  KeeNyung Lee ,  SunWook Kim ,  DaeYul Yoo

IPC分类号： C12Q1/68 ,  C07K14/47 ,  C07H21/04 ,  C12N15/63 ,  C12Q1/02 ,  C12N15/87 ,  C12N5/06 ,  A01K67/027

CPC分类号： C12N5/0646 ,  C07K14/4703 ,  C12N2501/998

摘要： The present invention is related to an agent for differentiating hematopoietic stem cell into natural killer cell comprising VDUP1 protein or gene encoding the same, and a method of differentiating hematopoietic stem cell into natural killer cell using thereof. The present invention reveals for the first time that the VDUP1 gene is a critical factor for the regulation of differentiation of natural killer cell by generating a mouse deficient in VDUP1 gene, which confirms that VDUP1 gene is required for NK maturation. Thus, through the regulation of VDUP1 gene, the modulation of NK cells that have ability to kill cancer cells is possible and can be utilized for cell therapeutics.

摘要翻译： 本发明涉及用于将造血干细胞分化成包含VDUP1蛋白或编码其的基因的天然杀伤细胞的试剂，以及使用其将造血干细胞分化为天然杀伤细胞的方法。 本发明首次揭示了VDUP1基因是通过产生VDUP1基因缺陷小鼠来调节天然杀伤细胞分化的关键因素，证实了VDUP1基因是NK成熟所必需的。 因此，通过调节VDUP1基因，能够杀死癌细胞的NK细胞的调节是可能的并且可以用于细胞治疗。