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    Method for inhibiting interleukin-6 production by administering extracts from root of Stephania tetrandra
    1.
    发明授权
    Method for inhibiting interleukin-6 production by administering extracts from root of Stephania tetrandra 失效
    通过施用来自Stephania tetrandra的根的提取物来抑制白细胞介素-6产生的方法

    公开(公告)号：US6162437A

    公开(公告)日：2000-12-19

    申请号：US978321

    申请日：1997-11-25

    申请人： Kwang-Ho Pyun ,  Inpyo Choi ,  Hyung-Sik Kang ,  Jung-Joon Lee ,  Young-Ho Kim

    发明人： Kwang-Ho Pyun ,  Inpyo Choi ,  Hyung-Sik Kang ,  Jung-Joon Lee ,  Young-Ho Kim

    IPC分类号： A61K36/59 ,  A61K35/78

    CPC分类号： A61K36/59

    摘要： Method for inhibiting the production of interleukin-6 (hereinafter, referred to as "IL-6") in human body, which comprises administering extracts from a root of Stephania tetrandra S. Moore; and method for treating a patient of an immune disease caused by an overproduction of interleukin-6 by inhibiting the production of interleukin-6, which comprises administering extracts from a root of Stephania tetrandra S. Moore to the patient.

    摘要翻译： 抑制人体中白细胞介素-6（以下称为“IL-6”）的产生的方法，其包括施用来自Stephania tetrandra S.Moore的根的提取物; 以及通过抑制白细胞介素-6的产生来治疗由白细胞介素-6过量产生引起的免疫疾病的患者的方法，其包括向患者施用来自Stephania tetrandra S.Moore的根的提取物。

    Method of differentiating hematopoietic stem cells into natural killer cells using YC-1 or IL-21
    2.
    发明授权
    Method of differentiating hematopoietic stem cells into natural killer cells using YC-1 or IL-21 有权
    使用YC-1或IL-21将造血干细胞分化成自然杀伤细胞的方法

    公开(公告)号：US08318491B2

    公开(公告)日：2012-11-27

    申请号：US12671814

    申请日：2007-10-02

    申请人： Inpyo Choi ,  SukRan Yoon ,  Sohyun Yun ,  Jin Woong Chung

    发明人： Inpyo Choi ,  SukRan Yoon ,  Sohyun Yun ,  Jin Woong Chung

    IPC分类号： C07K5/02 ,  C12N5/02 ,  C07D209/04

    CPC分类号： A61K31/416

    摘要： The present invention relates to an agent for differentiating hematopoietic stem cells into natural killer cells and a method for the differentiation, more precisely an agent for differentiating hematopoietic stem cells into natural killer cells comprising YC-I [3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole] or IL-21 (Interleukin-21) as an active ingredient and a method for differentiating hematopoietic stem cells into natural killer cells using the same. The YC-I and IL-21 regulate the differentiation of hematopoietic stem cells into natural killer cells and increase the killing activity of NK cells. Therefore, the agent for NK cell differentiation of the present invention can be effectively used for cell therapy for the treatment of cancer by regulating the differentiation of hematopoietic stem cells into natural killer cells having tumor cell killing activity.

    摘要翻译： 本发明涉及用于将造血干细胞分化为天然杀伤细胞的试剂和分化方法，更准确地说，用于将造血干细胞分化成包含YC-1 [3-（5'-羟甲基-2 糠基）-1-苄基吲唑]或IL-21（白细胞介素-21）作为活性成分，以及使用其将造血干细胞分化为天然杀伤细胞的方法。 YC-1和IL-21调节造血干细胞分化为自然杀伤细胞，增加NK细胞的杀伤活性。 因此，通过调节造血干细胞分化为具有肿瘤细胞杀伤活性的天然杀伤细胞，本发明的NK细胞分化剂可以有效地用于治疗癌症的细胞治疗。

    METHOD FOR ACTIVATING A NATURAL KILLER CELL BY ADJUSTING THE EXPRESSION OF THE SOCS2 GENE
    3.
    发明申请
    METHOD FOR ACTIVATING A NATURAL KILLER CELL BY ADJUSTING THE EXPRESSION OF THE SOCS2 GENE 审中-公开
    通过调节SOCS2基因的表达来激活自然杀伤细胞的方法

    公开(公告)号：US20120282646A1

    公开(公告)日：2012-11-08

    申请号：US13504109

    申请日：2010-08-30

    申请人： Inpyo Choi ,  Suk Hyung Lee ,  Suk-Ran Yoon

    发明人： Inpyo Choi ,  Suk Hyung Lee ,  Suk-Ran Yoon

    IPC分类号： C12N5/0783 ,  C12Q1/02 ,  C12N15/85

    CPC分类号： A61K35/17 ,  C12N5/0646 ,  C12N2501/998 ,  C12N2510/00

    摘要： The present invention relates to a method for activating natural killer cells (NK cells), and more particularly, to a method for enhancing the cytotoxicity of natural killer cells by inducing the overexpression of suppressor of cytokine signaling 2 (SOCS2) which is a protein involved in cell-signaling pathways in natural killer cells. The inventors of the present invention observed that when natural killer cells were treated with IL-15, a cytokine involved in natural killer cell differentiation, the expression of SOCS2 increased and the expression of proline-rich tyrosine kinase 2 (Pyk2) was inhibited by the SOCS2, the expression of which increased. In addition, when Pyk2 was overexpressed, the ability to produce IFN-γ and the ability to kill tumor cells of natural killer cells decreased. Therefore, SOCS2 can be used for activating natural killer cells and the natural killer cells activated by the method can be used for the prevention or treatment of cancer.

    摘要翻译： 本发明涉及一种用于激活天然杀伤细胞（NK细胞）的方法，更具体地说，涉及通过诱导涉及蛋白质的细胞因子信号传导抑制剂（SOCS2）的过表达来提高天然杀伤细胞的细胞毒性的方法 在自然杀伤细胞的细胞信号通路中。 本发明的发明人观察到，当用IL-15（参与自然杀伤细胞分化的细胞因子）处理天然杀伤细胞时，SOCS2的表达增加，富含脯氨酸的酪氨酸激酶2（Pyk2）的表达受到抑制 SOCS2，其表达增加。 此外，当Pyk2过表达时，产生IFN-γ的能力和杀死自然杀伤细胞的肿瘤细胞的能力下降。 因此，SOCS2可用于激活自然杀伤细胞，并且通过该方法活化的天然杀伤细胞可用于预防或治疗癌症。

    Method for Efficiently Proliferating and Differentiating Natural Killer Cells from Umbilical Cord Blood
    4.
    发明申请
    Method for Efficiently Proliferating and Differentiating Natural Killer Cells from Umbilical Cord Blood 审中-公开
    有效增殖和分化天然杀伤细胞与脐带血的方法

    公开(公告)号：US20120121544A1

    公开(公告)日：2012-05-17

    申请号：US13125643

    申请日：2009-09-28

    申请人： Inpyo Choi ,  Suk-Ran Yoon ,  Soo Yun Lee ,  Joo-Yong Lee ,  Jaeseung Lim

    发明人： Inpyo Choi ,  Suk-Ran Yoon ,  Soo Yun Lee ,  Joo-Yong Lee ,  Jaeseung Lim

    IPC分类号： A61K35/12 ,  A61P35/00 ,  C12N5/02

    CPC分类号： C12N5/0646 ,  C12N2501/2302 ,  C12N2501/2315 ,  C12N2501/2321

    摘要： The present invention relates to a method for efficiently proliferating and differentiating natural killer cells (NK cells) from umbilical cord blood, more precisely a method for efficiently proliferating and differentiating natural killer cells from umbilical cord blood comprising the following steps: 1) preparing CD3 negative cells by eliminating CD3 positive T-cells from umbilical cord blood derived mononuclear cells; and 2) culturing the CD3 negative cells after treating various cytokines thereto. The present invention is advantageous in obtaining high purity NK cells in a short period of time by inducing NK cells from CD3 negative cells, compared with the conventional method inducing NK cells from haematopoietic stem cells, and in promoting NK cell proliferation and differentiation by treating different cytokines together, for example by the co-treatment of IL-15 and IL-21. That is, the method of the present invention can induce NK cells with increased anti-cancer cytotoxicity, so that it can be effectively used for anti-cancer cell therapy.

    摘要翻译： 本发明涉及一种有效增殖和分化脐带血自然杀伤细胞（NK细胞）的方法，更确切地说，一种有效增殖和分化脐带血自然杀伤细胞的方法，包括以下步骤：1）制备CD3阴性 通过从脐带血衍生的单核细胞中消除CD3阳性T细胞的细胞; 和2）在处理各种细胞因子后培养CD3阴性细胞。 本发明与从造血干细胞诱导NK细胞的常规方法相比，通过诱导CD3阴性细胞的NK细胞在短时间内获得高纯度NK细胞是有利的，并且通过治疗不同的方法促进NK细胞增殖和分化 细胞因子在一起，例如通过共同治疗IL-15和IL-21。 也就是说，本发明的方法可以诱导具有增加的抗癌细胞毒性的NK细胞，从而可以有效地用于抗癌细胞治疗。

    Differentiation regulating agent containing gene which regulating differentiation from stem cells into natural killer cells as effective ingredient
    6.
    发明申请
    Differentiation regulating agent containing gene which regulating differentiation from stem cells into natural killer cells as effective ingredient 审中-公开
    分化调节剂含有调节干细胞分化为天然杀伤细胞作为有效成分的基因

    公开(公告)号：US20070042344A1

    公开(公告)日：2007-02-22

    申请号：US10597305

    申请日：2005-01-20

    申请人： Inpyo Choi ,  Hyung-Sik Kang ,  Suk-Ran Yoon ,  Eun-Mi Kim

    发明人： Inpyo Choi ,  Hyung-Sik Kang ,  Suk-Ran Yoon ,  Eun-Mi Kim

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  C12N5/08

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C12N5/0646 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The present invention relates to a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into natural killer cells as an effective ingredient, more precisely, a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into premature natural killer cells as an effective ingredient and a screening method of the gene by taking advantage of SAGE. The gene of the present invention is a novel one that is confirmed not to be like any other known genes regulating differentiation from stem cells into natural killer cells. Though, the gene can be easily screened by SAGE and a natural killer cell differentiation-regulating agent containing the gene as an effective ingredient can be effectively used as an anticancer agent.

    摘要翻译： 本发明涉及含有调节从干细胞分化为天然杀伤细胞作为有效成分的基因的细胞分化调节剂，更确切地说，涉及含有调节从干细胞分化为过早天然杀伤细胞的基因的细胞分化调节剂 有效成分和利用SAGE的基因筛选方法。 本发明的基因是一种新的，被证明不像调节从干细胞分化为天然杀伤细胞的任何其它已知的基因。 虽然该基因可以容易地被SAGE筛选，并且含有该基因作为有效成分的天然杀伤细胞分化调节剂可以有效地用作抗癌剂。

    Composition Containing Osteopontin for Differentiating Natural Killer Cell as an Active Ingredient and a Method of Differentiation Using Thereof
    10.
    发明申请
    Composition Containing Osteopontin for Differentiating Natural Killer Cell as an Active Ingredient and a Method of Differentiation Using Thereof 审中-公开
    含有骨桥蛋白的组合物，用于将天然杀伤细胞分化为活性成分和使用它们的分化方法

    公开(公告)号：US20110305680A1

    公开(公告)日：2011-12-15

    申请号：US12995020

    申请日：2008-11-10

    申请人： Inpyo Choi ,  Jin Woong Chung ,  Misun Kim ,  Suk Ran Yoon

    发明人： Inpyo Choi ,  Jin Woong Chung ,  Misun Kim ,  Suk Ran Yoon

    IPC分类号： A61K35/12 ,  A61P35/00 ,  C12N5/0783

    CPC分类号： A61K38/19 ,  A61K35/17 ,  C12N5/0646 ,  C12N2501/998

    摘要： The present invention relates to a composition for differentiating natural killer cells comprising osteopontin (OPN) as an active ingredient and a method for differentiation using the same. More precisely, osteopontin of the present invention accelerates differentiation of natural killer cells from hematopoietic stem cells and increases cytotoxic activity of natural killer cells, so that it can be effectively used as a composition for differentiating natural killer cells. OPN of the present invention regulates differentiation of natural killer cells capable of killing cancer cells, so that it can be effectively used for the treatment of cancer.

    摘要翻译： 本发明涉及用于分化包含骨桥蛋白（OPN）作为活性成分的天然杀伤细胞的组合物和使用其的分化方法。 更准确地说，本发明的骨桥蛋白加速了造血干细胞中天然杀伤细胞的分化，并增加了天然杀伤细胞的细胞毒活性，因此可有效地用作分化天然杀伤细胞的组合物。 本发明的OPN调节能够杀死癌细胞的天然杀伤细胞的分化，从而可以有效地用于治疗癌症。