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1.
公开(公告)号:US09309313B2
公开(公告)日:2016-04-12
申请号:US12812084
申请日:2009-01-09
申请人: Reza Dana , Sunil Chauhan
发明人: Reza Dana , Sunil Chauhan
IPC分类号: A61K39/395 , A61K9/00 , A61K39/00 , C07K16/22 , C07K16/24 , A61K31/724 , A61K31/728 , A61K38/17 , A61K38/20 , A61K45/06 , C07K14/54
CPC分类号: A61K39/3955 , A61K9/0048 , A61K9/0051 , A61K31/724 , A61K31/728 , A61K38/1793 , A61K38/20 , A61K45/06 , A61K2039/505 , C07K14/54 , C07K16/244 , C07K16/2866 , C07K2317/75 , C07K2317/76 , A61K2300/00
摘要: The invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-17 and methods for using this composition to treat IL-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.
摘要翻译: 本发明包括具有抑制炎性细胞因子IL-17功能的方法的组合物和使用该组合物治疗IL-17介导的眼部炎症性疾病的方法。 本发明还公开了用于将该组合物递送至眼睛的装置。
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公开(公告)号:US20120014970A1
公开(公告)日:2012-01-19
申请号:US13183231
申请日:2011-07-14
申请人: Reza Dana , Mohammad Dastjerdi , Sunil Chauhan
发明人: Reza Dana , Mohammad Dastjerdi , Sunil Chauhan
IPC分类号: A61K39/395 , A61P29/00 , A61P25/00 , A61K38/16 , A61P27/02
CPC分类号: A61K38/1709 , A61K9/0048 , A61K47/183 , A61K47/38 , C12N15/1136 , C12N2310/14 , A61K2300/00
摘要: The invention provides methods and compositions for minimizing, preventing, or treating damage to corneal nerves by administering to a subject with such damage or at risk of exposure to such damage a composition which blocks an activity of an IL-1 cytokine and/or an IL-17 cytokine.
摘要翻译: 本发明提供了通过向受试者施用具有这种损伤或有暴露于此类损伤的风险的方式来减少,预防或治疗对角膜神经的损伤的方法和组合物,该组合物阻断IL-1细胞因子和/或IL的活性 -17细胞因子。
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公开(公告)号:US20100183587A1
公开(公告)日:2010-07-22
申请号:US12685510
申请日:2010-01-11
申请人: Reza Dana , Mohammad Dastjerdi , Sunil Chauhan
发明人: Reza Dana , Mohammad Dastjerdi , Sunil Chauhan
IPC分类号: A61K39/395 , A61K38/17 , A61K31/7088 , A61K31/6615 , A61K31/713 , A61P37/00 , A61P27/02
CPC分类号: A61K38/1709 , A61K9/0048 , A61K38/1793 , A61K38/2006 , C12N15/1136 , C12N2310/14 , A61K2300/00
摘要: The invention provides methods and compositions for minimizing, preventing, or treating damage to corneal nerves by administering to a subject with such damage or at risk of exposure to such damage a composition which blocks an activity of an IL-1 cytokine and/or an IL-17 cytokine.
摘要翻译: 本发明提供了通过向受试者施用具有这种损伤或有暴露于此类损伤的风险的方式来减少,预防或治疗对角膜神经的损伤的方法和组合物,该组合物阻断IL-1细胞因子和/或IL的活性 -17细胞因子。
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公开(公告)号:US09328162B2
公开(公告)日:2016-05-03
申请号:US13579170
申请日:2011-02-25
申请人: Reza Dana , Sunil Chauhan
发明人: Reza Dana , Sunil Chauhan
IPC分类号: A61K38/02 , A61P27/02 , C07K16/22 , A61K38/17 , A61K9/00 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号: A61K38/13 , A61K9/0048 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K38/179 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/76
摘要: Described herein are materials and methods of treating dry eye disease in a subject.
摘要翻译: 本文描述了治疗受试者的干眼病的材料和方法。
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公开(公告)号:US09011861B2
公开(公告)日:2015-04-21
申请号:US13035695
申请日:2011-02-25
申请人: Reza Dana , Sunil Chauhan
发明人: Reza Dana , Sunil Chauhan
IPC分类号: A61K39/395 , C07K16/22 , A61K38/17 , A61K9/00 , A61K39/00
CPC分类号: A61K38/13 , A61K9/0048 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K38/179 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/76
摘要: Described herein are materials and methods for treating dry eye disease in a subject.
摘要翻译: 本文描述了用于治疗受试者的干眼病的材料和方法。
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6.
公开(公告)号:US20110104236A1
公开(公告)日:2011-05-05
申请号:US12812084
申请日:2009-01-09
申请人: Reza Dana , Sunil Chauhan
发明人: Reza Dana , Sunil Chauhan
IPC分类号: A61K9/00 , A61K39/395 , A61K47/38 , A61K47/40 , A61P27/04 , A61P27/02 , A61P27/14 , A61P29/00 , A61P25/00
CPC分类号: A61K39/3955 , A61K9/0048 , A61K9/0051 , A61K31/724 , A61K31/728 , A61K38/1793 , A61K38/20 , A61K45/06 , A61K2039/505 , C07K14/54 , C07K16/244 , C07K16/2866 , C07K2317/75 , C07K2317/76 , A61K2300/00
摘要: The invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-17 and methods for using this composition to treat IL-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.
摘要翻译: 本发明包括具有抑制炎性细胞因子IL-17功能的方法的组合物和使用该组合物治疗IL-17介导的眼部炎症性疾病的方法。 本发明还公开了用于将该组合物递送至眼睛的装置。
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公开(公告)号:US10117906B2
公开(公告)日:2018-11-06
申请号:US12685510
申请日:2010-01-11
申请人: Reza Dana , Mohammad Dastjerdi , Sunil Chauhan
发明人: Reza Dana , Mohammad Dastjerdi , Sunil Chauhan
IPC分类号: A61K38/00 , A61K49/00 , A61B5/00 , A61K38/19 , A61K38/20 , A61K38/17 , A61K9/00 , C12N15/113
摘要: The invention provides methods and compositions for minimizing, preventing, or treating damage to corneal nerves by administering to a subject with such damage or at risk of exposure to such damage a composition which blocks an activity of an IL-1 cytokine and/or an IL-17 cytokine.
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公开(公告)号:US20130045927A1
公开(公告)日:2013-02-21
申请号:US13579170
申请日:2011-02-25
申请人: Reza Dana , Sunil Chauhan
发明人: Reza Dana , Sunil Chauhan
CPC分类号: A61K38/13 , A61K9/0048 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K38/179 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/76
摘要: Described herein are materials and methods of treating dry eye disease in a subject.
摘要翻译: 本文描述了治疗受试者的干眼病的材料和方法。
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公开(公告)号:US20110206620A1
公开(公告)日:2011-08-25
申请号:US13035695
申请日:2011-02-25
申请人: Reza Dana , Sunil Chauhan
发明人: Reza Dana , Sunil Chauhan
IPC分类号: A61K39/395 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K31/715 , A61K9/12 , A61K38/18 , A61P27/02
CPC分类号: A61K38/13 , A61K9/0048 , A61K31/404 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K38/179 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/76
摘要: Described herein are materials and methods for treating dry eye disease in a subject.
摘要翻译: 本文描述了用于治疗受试者的干眼病的材料和方法。
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