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    RNA aptamers and the uses thereof
    1.
    发明授权
    RNA aptamers and the uses thereof 有权
    RNA适体及其用途

    公开(公告)号：US07999089B1

    公开(公告)日：2011-08-16

    申请号：US12064384

    申请日：2006-10-09

    申请人： Sunjoo Jeong ,  Hee kyu Lee ,  Min woo Park

    发明人： Sunjoo Jeong ,  Hee kyu Lee ,  Min woo Park

    IPC分类号： C07H21/04 ,  C12N15/00

    CPC分类号： C12N15/115 ,  C12N2310/111 ,  C12N2310/16

    摘要： The present invention relates to RNA aptamers and uses thereof, more precisely RNA aptamers interfering the interaction of TCF with other proteins by binding specifically to β-catenin, RNA aptamers binding specifically to HMG domains of TCF-I proteins and uses of the same. The RNA aptamer of the present invention can be effectively used for the development of an anticancer agent since it binds specifically to TCF-I to interrupt the interaction of TCF with β-catenin involved in tumorigenesis and metastasis and the transcriptional activity of TCF-I in relation to oncogenes.

    摘要翻译： 本发明涉及RNA适体及其用途，更确切地说，RNA适体通过特异性结合与β-纤维连接蛋白，特异性结合TCF-1蛋白的HMG结构域的RNA适配子及其用途而干扰TCF与其他蛋白质的相互作用。 本发明的RNA适体可以有效地用于抗癌剂的开发，因为它特异性结合TCF-1以阻断TCF与参与肿瘤发生和转移的β-联蛋白的相互作用以及TCF-1的转录活性 关于癌基因。

    Carbohydrate-specific peptides which have a strong affinity and preparations method thereof
    2.
    发明授权
    Carbohydrate-specific peptides which have a strong affinity and preparations method thereof 失效
    具有强亲和力的碳水化合物特异性肽及其制备方法

    公开(公告)号：US07101841B2

    公开(公告)日：2006-09-05

    申请号：US10474667

    申请日：2001-12-05

    申请人： Jaehoon Yu ,  Miyun Kwon ,  Sunjoo Jeong

    发明人： Jaehoon Yu ,  Miyun Kwon ,  Sunjoo Jeong

    IPC分类号： A01N37/18 ,  A61K38/00

    CPC分类号： C07K7/08

    摘要： The present invention relates to carbohydrate-specific peptides, which have a strong affinity and preparation method thereof. Particularly, the present invention relates to carbohydrate-specific peptides, which have been developed to have an increased strong affinity to carbohydrates by the multiple combinations of peptides having carbohydrates-specific amino acid sequences and preparation method thereof. Carbohydrate-specific peptides of the present invention have a very strong affinity under micromol, so that they can shut off recognition between cells transferred by specific carbohydrates, which means they can be used for the treatment of diseases mediated by recognition between cells and used as a diagnostic kit which diagnoses diseases by confirming the existence of any specific carbohydrate.

    摘要翻译： 本发明涉及具有很强亲和力的碳水化合物特异性肽及其制备方法。 特别地，本发明涉及通过具有碳水化合物特异性氨基酸序列的肽的多重组合对碳水化合物具有增强的强亲和力的碳水化合物特异性肽及其制备方法。 本发明的碳水化合物特异性肽在微摩尔下具有非常强的亲和力，使得它们可以切断由特定碳水化合物转移的细胞之间的识别，这意味着它们可以用于治疗由细胞之间的识别介导的疾病，并用作 通过确认任何特定碳水化合物的存在来诊断疾病的诊断试剂盒。