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1.发明授权公开(公告)号：US08957114B2
公开(公告)日：2015-02-17
申请号：US13513170
申请日：2010-12-03
申请人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Philip James Bonasia , Susan S. D'Souza
发明人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Philip James Bonasia , Susan S. D'Souza
IPC分类号： A01N33/02 , A61K31/135 , C07C211/00 , A61K9/20 , A61K9/48 , C07C211/42
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/4858 , C07C211/42
摘要： Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.
摘要翻译： 本文提供的药物组合物包含过度心律，盐和多形态的跨屈曲胆碱，制备组合物的方法，及其用于治疗包括抑郁症在内的CNS疾病的方法。
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2.发明授权Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine 有权反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的制备方法公开(公告)号：US08329950B2
公开(公告)日：2012-12-11
申请号：US13358155
申请日：2012-01-25
申请人： Judy Caron , Thomas Wessel , Karim Lalji , Mark Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Han , Stefan G. Koenig
发明人： Judy Caron , Thomas Wessel , Karim Lalji , Mark Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Han , Stefan G. Koenig
IPC分类号： C07C209/62
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译： 本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。 药物组合物的第一组分是镇静剂佐佐匹克。 药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） 2,3,4-四氢-1-萘胺。 本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。
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3.发明申请Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders 审中-公开依佐匹克隆和反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基）-1,2,3， 4-四氢-1-萘胺，以及更年期和心情，焦虑和认知障碍的治疗方法公开(公告)号：US20080293726A1
公开(公告)日：2008-11-27
申请号：US11994644
申请日：2006-07-06
申请人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
发明人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
IPC分类号： A61K31/498 , C07C209/22 , A61P25/00
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译： 本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。 药物组合物的第一组分是镇静剂佐佐匹克。 药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） 2,3,4-四氢-1-萘胺。 本发明还涉及一种治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。
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公开(公告)号：US20130116332A1
公开(公告)日：2013-05-09
申请号：US13513170
申请日：2010-12-03
申请人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Phillip James Bonasia , Susan S. D'souza
发明人： Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Phillip James Bonasia , Susan S. D'souza
IPC分类号： A61K31/135 , C07C211/42
CPC分类号： A61K31/135 , A61K9/2018 , A61K9/4858 , C07C211/42
摘要： Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.
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5.发明申请Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders 有权依佐匹克隆和反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基）-1,2,3， 4-四氢-1-萘胺，以及更年期和心情，焦虑和认知障碍的治疗方法公开(公告)号：US20120123164A1
公开(公告)日：2012-05-17
申请号：US13358155
申请日：2012-01-25
申请人： Judy CARON , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
发明人： Judy CARON , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
IPC分类号： C07C209/28
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译： 本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。 药物组合物的第一组分是镇静剂佐佐匹克。 药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） 2,3,4-四氢-1-萘胺。 本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。
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