公开(公告)号：US06828334B2

公开(公告)日：2004-12-07

申请号：US10338562

申请日：2003-01-07

Applicant: Suresh Kumar Gidwani ,  Purushottam Sharshikant Singnurkar

Inventor： Suresh Kumar Gidwani ,  Purushottam Sharshikant Singnurkar

IPC: A61K900

CPC classification number: B82Y5/00 ,  A61K8/37 ,  A61K8/738 ,  A61K9/06 ,  A61K9/1075 ,  A61K9/1272 ,  A61K9/5084 ,  A61K31/05 ,  A61K31/216 ,  A61K45/06 ,  A61K2800/412 ,  A61K2800/56 ,  A61Q7/00

Abstract: The present invention relates to pharmaceutical compositions containing fenofibrate in the form of an inclusion complex with cyclodextrin, having high dissolution profile and in vivo enhanced bioavailability as compared with plain micronized fenofibrate compositions. An inclusion complex has a molar ratio of fenofibrate (preferably in micronized form) to cyclodextrin of from about 1:0.5 to about 1:4, preferably from about 1:1 to about 1:2. The immediate release fenofibrate composition is preferably in the form of a tablet or in the form of granules inside a capsule.

Abstract translation: 本发明涉及与普通微粉化的非诺贝特组合物相比，含有与环糊精包合物形式的非诺贝特的药物组合物，其具有高溶解曲线和体内增强的生物利用度。 包合络合物具有约1:0.5至约1:4，优选约1:1至约1:2的非诺贝特（优选微粉化形式）与环糊精的摩尔比。 立即释放的非诺贝特组合物优选为片剂的形式或胶囊内的颗粒形式。

公开(公告)号：US06464988B1

公开(公告)日：2002-10-15

申请号：US09852141

申请日：2001-05-09

Applicant: Suresh Kumar Gidwani ,  Purushottam Singnurkar ,  Prashant Kumar Tewari

Inventor： Suresh Kumar Gidwani ,  Purushottam Singnurkar ,  Prashant Kumar Tewari

IPC: A61K900

CPC classification number: B82Y5/00 ,  A61K47/6951

Abstract: Inclusion complexes of glipizide and a nonionic surfactant with cyclodextrin and cyclodextrin derivatives. A method of preparing the inclusion complexes of glipizide and a nonionic surfactant with cyclodextrin and cyclodextrin derivatives, by wetting cyclodextrin or a derivative thereof with a nonionic surfactant, and mixing the resulting mixture with glipizide. A pharmaceutical composition containing an inclusion complex of glipizide and a nonionic surfactant with cyclodextrin and cyclodextrin derivatives, in combination with pharmaceutically acceptable excipients.

Abstract translation: 格列吡嗪和非离子表面活性剂与环糊精和环糊精衍生物的包合物。 通过用非离子表面活性剂润湿环糊精或其衍生物，并将所得混合物与格列吡嗪混合来制备格列吡嗪和非离子表面活性剂与环糊精和环糊精衍生物的包合物的方法。 含有格列吡嗪和非离子表面活性剂与环糊精和环糊精衍生物的包合物与药学上可接受的赋形剂组合的药物组合物。

公开(公告)号：US06462237B1

公开(公告)日：2002-10-08

申请号：US09881582

申请日：2001-06-14

Applicant: Suresh Kumar Gidwani ,  Purushottam Singnurkar ,  Prashant Kumar Tewari

Inventor： Suresh Kumar Gidwani ,  Purushottam Singnurkar ,  Prashant Kumar Tewari

IPC: C07C22100

CPC classification number: B82Y5/00 ,  A61K9/2077 ,  A61K9/2866 ,  A61K9/4808 ,  A61K47/6949

Abstract: An inclusion complex of bupropion hydrochloride with beta cyclodextrin that stabilizes the bupropion hydrochloride against degradation. A method of preparing an inclusion complex of bupropion hydrochloride with beta cyclodextrin that stabilizes the bupropion hydrochloride against degradation. A novel stabilized sustained-release pharmaceutical composition of bupropion hydrochloride containing an inclusion complex of bupropion hydrochloride with beta cyclodextrin. A method of preparing a novel stabilized sustained-release pharmaceutical composition containing an inclusion complex of bupropion hydrochloride with beta cyclodextrin.

Abstract translation: 盐酸安非他酮与β环糊精的包合物，使盐酸安非他酮稳定化，降解。 制备盐酸安非他酮与β-环糊精的包合物的方法，其使盐酸安非他酮稳定化以降解。 一种新颖的盐酸安非他酮缓释药物组合物，其含有盐酸安非他酮与β-环糊精的包合物。 一种制备含有盐酸安非他酮与β-环糊精的包合物的新型稳定缓释药物组合物的方法。

公开(公告)号：US06270797B1

公开(公告)日：2001-08-07

申请号：US09573290

申请日：2000-05-18

Applicant: Suresh Kumar Gidwani ,  Purushottam Singnurkar ,  Prashant Kumar Tewari

Inventor： Suresh Kumar Gidwani ,  Purushottam Singnurkar ,  Prashant Kumar Tewari

IPC: A61K952

CPC classification number: A61K31/64 ,  A61K9/2054

Abstract: One aspect of the invention resides in a monolithic sustained release composition of glipizide for patients with non-insulin dependent diabetes mellitus that exhibits a breakdown after ingestion by a patient in conformity with a zero-order kinetic. The present invention provides a composition of a glipizide and a hydrocolloid forming agent and optimally other auxiliary excipients for the sustained release of glipizide. It is preferable that the hydrophilic material comprises at least 50% by weight of the composition. The present invention is also directed to the process for producing the composition. One aspect of this process includes the steps of granulating glipizide, a hydrophilic material and a diluent, drying the granulated product and lubricating the product with a flow regulating agent and lubricant.

Abstract translation: 本发明的一个方面在于用于患有非胰岛素依赖性糖尿病的患者的格列吡嗪的单片持续释放组合物，其在患者摄取后显示符合零级动力学的分解。 本发明提供了格列吡嗪和水胶体形成剂的组合物以及用于持续释放格列吡嗪的最佳其它辅助赋形剂。 优选亲水材料包含至少50重量％的组合物。 本发明还涉及组合物的制造方法。 该方法的一个方面包括将格列吡嗪，亲水性材料和稀释剂造粒，干燥造粒产物并用流动调节剂和润滑剂润滑产品的步骤。