公开(公告)号：US20140155607A1

公开(公告)日：2014-06-05

申请号：US14009178

申请日：2012-04-04

Applicant: Purna Chandra Ray ,  Ashok Sopanrao Yadav ,  Dnyaneshwar Tukaram Singare ,  Surinder Kumar Arora ,  Girij Pal Singh

Inventor： Purna Chandra Ray ,  Ashok Sopanrao Yadav ,  Dnyaneshwar Tukaram Singare ,  Surinder Kumar Arora ,  Girij Pal Singh

IPC: C07D413/12

CPC classification number: C07D413/12 ,  A61K31/513 ,  C07C211/04

Abstract: The present invention provides novel salts of raltegravir, viz., meglumine salt, erbumine salt, ammonium salt, tris salt and L-arginine salt of raltegravir and processes for their preparation.

Abstract translation: 本发明提供了raltegravir的新型盐，即raltegravir的葡甲胺盐，erbumine盐，铵盐，三盐和L-精氨酸盐及其制备方法。

公开(公告)号：US20130174651A1

公开(公告)日：2013-07-11

申请号：US13822197

申请日：2011-09-05

Applicant: Surinder Kumar Arora ,  Samir Shanteshwar Shabade ,  Gaurav Kumar ,  Purna Chandra Ray ,  Girij Pal Singh

Inventor： Surinder Kumar Arora ,  Samir Shanteshwar Shabade ,  Gaurav Kumar ,  Purna Chandra Ray ,  Girij Pal Singh

IPC: C07D307/20 ,  G01N30/16

CPC classification number: C07F9/65515 ,  C07D307/20 ,  C07D405/12 ,  G01N30/16

Abstract: The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R) tetrahydro -3 -furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.

Abstract translation: 本发明涉及基本上不含异构体杂质的（3R）四氢-3-呋喃基（1S，2R）-3 - [[（4-氨基苯基）磺酰基]（异丁基）氨基] -1-苄基 -2-（膦酰氧基）丙基氨基甲酸酯（Ib）及其制备方法。 本发明还提供了基本上不含（R）-3-四氢呋喃基琥珀酰亚胺基碳酸酯（IIb）的扇贝纳可维酸钙中间体（S）-3-四氢呋喃基-N-琥珀酰亚胺基碳酸酯（IIa）及其制备方法。

公开(公告)号：US09163009B2

公开(公告)日：2015-10-20

申请号：US14009178

申请日：2012-04-04

Applicant: Purna Chandra Ray ,  Ashok Sopanrao Yadav ,  Dnyaneshwar Tukaram Singare ,  Surinder Kumar Arora ,  Girij Pal Singh

Inventor： Purna Chandra Ray ,  Ashok Sopanrao Yadav ,  Dnyaneshwar Tukaram Singare ,  Surinder Kumar Arora ,  Girij Pal Singh

IPC: C07D413/12 ,  A61K31/513

CPC classification number: C07D413/12 ,  A61K31/513 ,  C07C211/04

Abstract: The present invention provides novel salts of raltegravir, viz., meglumine salt, erbumine salt, ammonium salt, tris salt and L-arginine salt of raltegravir and processes for their preparation.

Abstract translation: 本发明提供了raltegravir的新型盐，即制备raltegravir的葡甲胺盐，erbumine盐，铵盐，三盐和L-精氨酸盐及其制备方法。

公开(公告)号：US08877947B2

公开(公告)日：2014-11-04

申请号：US13822197

申请日：2011-09-05

Applicant: Surinder Kumar Arora ,  Samir Shanteshwar Shabade ,  Gaurav Kumar ,  Purna Chandra Ray ,  Girij Pal Singh

Inventor： Surinder Kumar Arora ,  Samir Shanteshwar Shabade ,  Gaurav Kumar ,  Purna Chandra Ray ,  Girij Pal Singh

IPC: C07D307/20 ,  C07F9/06 ,  G01N30/16 ,  C07D405/12

CPC classification number: C07F9/65515 ,  C07D307/20 ,  C07D405/12 ,  G01N30/16

Abstract: The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R)tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.

Abstract translation: 本发明涉及基本上不含异构体杂质的福桑那韦钙（Ia），（3R）四氢-3-呋喃基（1S，2R）-3 - [[（4-氨基苯基）磺酰基]（异丁基）氨基] -1-苄基 -2-（膦酰氧基）丙基氨基甲酸酯（Ib）及其制备方法。 本发明还提供了基本上不含（R）-3-四氢呋喃基琥珀酰亚胺基碳酸酯（IIb）的扇贝纳可维酸钙中间体（S）-3-四氢呋喃基-N-琥珀酰亚胺基碳酸酯（IIa）及其制备方法。