公开(公告)号：US5531734A

公开(公告)日：1996-07-02

申请号：US372408

申请日：1995-01-13

申请人： Ronita K. Geckle ,  Terrence B. Mazer ,  Joseph E. Walton ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Mark A. McCamish ,  Robert L. Joseph ,  William G. Pierson

发明人： Ronita K. Geckle ,  Terrence B. Mazer ,  Joseph E. Walton ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Mark A. McCamish ,  Robert L. Joseph ,  William G. Pierson

IPC分类号： A61J15/00 ,  A61K9/22 ,  A61M5/00 ,  A61M5/14 ,  A61M31/00

CPC分类号： A61M31/002 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/007 ,  A61M5/1407 ,  A61J15/00

摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.

摘要翻译： 公开了一种用于在将液体肠内营养产品从供应容器输送到将营养产品输送到患者的胃肠道的进料管中时，用于改变液体肠内营养产品的方法。 在肠管喂养期间，营养产品通过配制室，例如滴注室，其中至少含有至少一种含有至少一种有益剂的控释剂型单元。 有益药物可以选自营养物，药物，益生菌或诊断剂或其混合物，以及任何这些与控制释放剂型中的生理学上可接受的标记染料和/或不是控制释放剂量的相同或不同的附加有益剂 形成。 受控释放剂型可以是常规的缓释型或渗透驱动的输送装置。

公开(公告)号：US5531682A

公开(公告)日：1996-07-02

申请号：US372266

申请日：1995-01-13

申请人： Terrence B. Mazer ,  Joseph E. Walton ,  Ronita K. Geckle ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Robert L. Joseph ,  William G. Pierson ,  Thomas D. Loughrin ,  Thomas W. Osip

发明人： Terrence B. Mazer ,  Joseph E. Walton ,  Ronita K. Geckle ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Robert L. Joseph ,  William G. Pierson ,  Thomas D. Loughrin ,  Thomas W. Osip

IPC分类号： A61J15/00 ,  A61M5/00 ,  A61M5/14 ,  A61M5/168 ,  A61M31/00 ,  G01N27/327 ,  A61M37/00

CPC分类号： A61M31/002 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/007 ,  A61M5/1407 ,  A61J15/00 ,  G01N33/02

摘要： An apparatus is useful for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. A formulation chamber, such as a drip chamber, is connectable to the supply container. At least one sustained release reservoir containing a physiologically acceptable marker dye is positioned within the formulation chamber, or if not, is included as part of a kit. The sustained release reservoir may be in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving material, or chopped hollow fibers having permeable walls. A liquid communication means connects the formulation chamber to the feeding tube of a patient. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. In using the apparatus for dye marking the nutritional product is flowed through the apparatus and a feeding tube to enter the gastrointestinal tract of a patient.

摘要翻译： 一种装置可用于将液体肠内营养产品在从供应容器输送到将营养产品输送到患者的胃肠道的喂食管中时进行标记。 诸如滴水室的配制室可连接到供应容器。 包含生理上可接受的标记染料的至少一个持续释放储存器位于制剂室内，或者如果不包含，则作为试剂盒的一部分。 持续释放储存器可以是包衣片剂，渗透驱动装置，包衣胶囊，微囊化微球，聚集分子筛材料或具有可渗透壁的切碎中空纤维的形式。 液体连通装置将制剂室连接到患者的进料管。 标记染料可以是着色剂染料或荧光染料或其混合物。 在使用染色标记设备时，营养产品流过设备和进料管进入患者的胃肠道。

公开(公告)号：US5531681A

公开(公告)日：1996-07-02

申请号：US372407

申请日：1995-01-13

申请人： Joseph E. Walton ,  Terrence B. Mazer ,  Ronita K. Geckle ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Mark A. McCamish ,  Robert L. Joseph ,  William G. Pierson

发明人： Joseph E. Walton ,  Terrence B. Mazer ,  Ronita K. Geckle ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Mark A. McCamish ,  Robert L. Joseph ,  William G. Pierson

IPC分类号： A61J15/00 ,  A61M5/00 ,  A61M5/14 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M31/002 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/007 ,  A61M5/1407 ,  A61J15/00

摘要： An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added. A liquid nutritional product flows through the formulation chamber during enteral tube feeding of a patient.

摘要翻译： 公开了一种用于在将液体肠内营养产品从其供应源（例如可吊起的容器）递送到将食用液体肠营养产品输送到患者的胃肠道的进料管中的情况下将液体肠内营养产品改性的装置。 该装置具有至少一个配方腔室，例如滴注室，其中至少一个以包衣片剂，渗透驱动装置，包衣胶囊，微胶囊化微球，聚集分子筛型材料形式的控释剂型单元，或 在其中的细中空可渗透纤维的数量。 控制释放剂型单元或单元含有至少一种选自营养物质，药物，益生菌或诊断剂或其混合物的有益剂，其中任何一种生物学可接受的控制释放剂型标记染料和/或相同或不同 可以加入不在控释剂型中的有益剂。 在患者的肠管喂养期间，液体营养产品流过制剂室。

公开(公告)号：US5549550A

公开(公告)日：1996-08-27

申请号：US372613

申请日：1995-01-13

申请人： Terrence B. Mazer ,  Joseph E. Walton ,  Ronita K. Geckle ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Robert L. Joseph ,  William G. Pierson ,  Thomas D. Loughrin ,  Thomas W. Osip

发明人： Terrence B. Mazer ,  Joseph E. Walton ,  Ronita K. Geckle ,  Carl J. Piontek ,  Susan B. Duel ,  Andre Daab-Krzykowski ,  Robert L. Joseph ,  William G. Pierson ,  Thomas D. Loughrin ,  Thomas W. Osip

IPC分类号： A61J15/00 ,  A61M5/00 ,  A61M5/14 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M31/002 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/007 ,  A61M5/1407 ,  A61J15/00

摘要： A method for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient includes the steps of: (1) providing apparatus such as a formulation chamber, e.g., a drip chamber, connectable to the supply container, with at least one sustained release reservoir containing a physiologically acceptable and dispersible marker dye positioned within the formulation chamber, and, liquid communication means connecting the formulation chamber to the feeding tube of a patient; (2) providing a supply container containing the nutritional product; (3) connecting the formulation chamber to the supply container and the liquid commmunication means to the feeding tube; and (4) flowing the dye-marked nutritional product through the apparatus and into the feeding tube. The sustained release reservoir may be a conventional slow release coated tablet, microspheres, or capsule type or an osmotically driven device. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. If quick coloration is desired, the sustained release reservoir may be coated with a soluble layer of the marker dye or marker dye not in a sustained release reservoir may be placed in the formulation chamber along with a sustained release reservoir containing dye.

摘要翻译： 一种将液体肠内营养产品从供应容器输送至将营养产品输送到患者的胃肠道的喂食管中的染色标记方法包括以下步骤：（1）提供诸如配制室的装置， 可连接到供应容器的滴水室与至少一个包含位于配制室内的生理上可接受和可分散的标记染料的缓释储存器，以及将配制室连接到患者的进料管的液体连通装置; （2）提供容纳营养产品的供应容器; （3）将制剂室与供给容器和液体通信装置连接到进料管; 和（4）使染料标记的营养产品通过设备流入饲管。 持续释放储存器可以是常规的缓释包衣片剂，微球体或胶囊型或渗透驱动装置。 标记染料可以是着色剂染料或荧光染料或其混合物。 如果需要快速着色，则持续释放储存器可以涂覆有标记染料的可溶层或不在持续释放储存器中的标记染料，可以与含有染料的持续释放储存器一起放置在配制室中。