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    Combined anti-tumor therapy with interleukin-2 and histamine, analogs thereof or H.sub.2 -receptor agonists
    2.
    发明授权
    Combined anti-tumor therapy with interleukin-2 and histamine, analogs thereof or H.sub.2 -receptor agonists 失效
    联合抗肿瘤治疗与白细胞介素-2和组胺，其类似物或H 2受体激动剂

    公开(公告)号：US5348739A

    公开(公告)日：1994-09-20

    申请号：US843052

    申请日：1992-03-02

    申请人： Jan U. K. Hellstrand ,  Svante H. Hermodsson

    发明人： Jan U. K. Hellstrand ,  Svante H. Hermodsson

    IPC分类号： A61K31/415 ,  A61K38/00 ,  A61K38/19 ,  A61K38/20 ,  A61K45/00 ,  A61K45/06 ,  A61P35/00 ,  A61P43/00 ,  A61K45/05 ,  C07K3/00

    CPC分类号： A61K45/06 ,  A61K38/2013 ,  Y10S514/885 ,  Y10S514/889

    摘要： A method of inhibiting the development of malignant tumors and the formation of metastases of malignant tumor cells in a subject carrying the comprises administering to the subject IL-2 and an agent selected from the group consisting of histamine, a histamine structural analogs having H.sub.2 -receptor activities, an endogenous histamine releasing preparation, and a non-histamine derivative H.sub.2 -receptor agonist; the agent and the IL-2 being administered in amounts and for a time effective to attain the desired effect. A method of increasing the anti-tumor cell effect of IL-2 in a subject comprises co-administering to the subject IL-2 and an agent such as histamine, histamine structural analogs having H.sub.2 -receptor activities, endogenous histamine releasing preparations or H.sub.2 -receptor agonists, the agent and the IL-2 being administered in anti-tumor effective amounts and for a period of time effective to attain the desired effect.

    摘要翻译： 一种抑制恶性肿瘤发展和恶性肿瘤细胞转移形成的方法，包括向受试者施用IL-2和选自组胺，具有H 2受体的组胺结构类似物 活性，内源性组胺释放制剂和非组胺衍生物H 2受体激动剂; 该药剂和IL-2以有效达到预期效果的量和一段时间施用。 增加受试者中IL-2的抗肿瘤细胞效应的方法包括共同施用受试者IL-2和剂，例如组胺，具有H 2受体活性的组胺结构类似物，内源性组胺释放制剂或H 2 - 受体激动剂，所述药剂和IL-2以抗肿瘤有效量施用和持续一段时间以达到期望的效果。