公开(公告)号：US5275016A

公开(公告)日：1994-01-04

申请号：US873327

申请日：1992-04-24

申请人： Bikash K. Chatterjee ,  Steven N. Buhl ,  Chi-Sou Yu ,  Thuy N. Tang ,  Gary L. Smith ,  Bhaskar Bhayani ,  Anthony Alvarado ,  Swee Wong

发明人： Bikash K. Chatterjee ,  Steven N. Buhl ,  Chi-Sou Yu ,  Thuy N. Tang ,  Gary L. Smith ,  Bhaskar Bhayani ,  Anthony Alvarado ,  Swee Wong

IPC分类号： F25D3/10 ,  A23L3/375 ,  A61J3/00 ,  A61J3/06 ,  B01J19/06 ,  F25C1/00 ,  F26B5/06 ,  G01N1/42 ,  F25D25/02

CPC分类号： A23L3/375 ,  B01J19/06 ,  F25C1/00 ,  F26B5/06 ,  G01N1/42

摘要： The present invention provides methods and devices for freezing drops of liquid reagent solution in a cryogenic liquid. In one embodiment, the apparatus of the present invention comprises means for dispensing uniform, precisely measured drops of a liquid reagent and a rotatable carousel positioned below the dispensing means. The upper surface of the carousel has a plurality of trays each containing a cryogenic liquid, typically liquid nitrogen, for receiving the drops of liquid reagent. An alternative embodiment of the present invention comprises a tank comprising a cryogenic liquid for receiving the drops of liquid reagent. The tank has a heat source for slightly heating a portion of the cryogenic liquid such that a convection current in the cryogenic liquid is created. The convection currents in the cryogenic liquid provide mild agitation of the liquid and prevent aggregation of the frozen drops.

摘要翻译： 本发明提供用于冷冻液体试剂溶液在低温液体中的液滴的方法和装置。 在一个实施例中，本发明的装置包括用于分配均匀的精确测量的液体试剂液滴和位于分配装置下方的可旋转转盘的装置。 转盘的上表面具有多个托盘，每个托盘包含用于接收液体试剂液滴的低温液体，通常为液氮。 本发明的替代实施方案包括一个包含用于接收液体试剂滴的低温液体的罐。 罐具有用于稍微加热部分低温液体的热源，使得产生低温液体中的对流。 低温液体中的对流电流提供液体的温和搅拌并防止冷冻液滴的聚集。