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公开(公告)号:US5275016A
公开(公告)日:1994-01-04
申请号:US873327
申请日:1992-04-24
申请人: Bikash K. Chatterjee , Steven N. Buhl , Chi-Sou Yu , Thuy N. Tang , Gary L. Smith , Bhaskar Bhayani , Anthony Alvarado , Swee Wong
发明人: Bikash K. Chatterjee , Steven N. Buhl , Chi-Sou Yu , Thuy N. Tang , Gary L. Smith , Bhaskar Bhayani , Anthony Alvarado , Swee Wong
IPC分类号: F25D3/10 , A23L3/375 , A61J3/00 , A61J3/06 , B01J19/06 , F25C1/00 , F26B5/06 , G01N1/42 , F25D25/02
摘要: The present invention provides methods and devices for freezing drops of liquid reagent solution in a cryogenic liquid. In one embodiment, the apparatus of the present invention comprises means for dispensing uniform, precisely measured drops of a liquid reagent and a rotatable carousel positioned below the dispensing means. The upper surface of the carousel has a plurality of trays each containing a cryogenic liquid, typically liquid nitrogen, for receiving the drops of liquid reagent. An alternative embodiment of the present invention comprises a tank comprising a cryogenic liquid for receiving the drops of liquid reagent. The tank has a heat source for slightly heating a portion of the cryogenic liquid such that a convection current in the cryogenic liquid is created. The convection currents in the cryogenic liquid provide mild agitation of the liquid and prevent aggregation of the frozen drops.
摘要翻译: 本发明提供用于冷冻液体试剂溶液在低温液体中的液滴的方法和装置。 在一个实施例中,本发明的装置包括用于分配均匀的精确测量的液体试剂液滴和位于分配装置下方的可旋转转盘的装置。 转盘的上表面具有多个托盘,每个托盘包含用于接收液体试剂液滴的低温液体,通常为液氮。 本发明的替代实施方案包括一个包含用于接收液体试剂滴的低温液体的罐。 罐具有用于稍微加热部分低温液体的热源,使得产生低温液体中的对流。 低温液体中的对流电流提供液体的温和搅拌并防止冷冻液滴的聚集。
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公开(公告)号:US5998031A
公开(公告)日:1999-12-07
申请号:US951617
申请日:1997-10-16
申请人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
发明人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
CPC分类号: G01N33/68 , A61K9/1694 , C12Q1/42 , G01N33/491 , G01N33/50 , G01N33/585 , G01N33/587 , G01N33/84 , Y10S436/805 , Y10S436/808 , Y10T428/13 , Y10T428/2982 , Y10T436/101666 , Y10T436/111666
摘要: The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers.
摘要翻译: 本发明提供包含干燥珠粒的干燥化学组合物。 通常,珠粒包含适于分析生物样品的试剂,特别是离心分析仪中血液样品的分析。
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公开(公告)号:US06251684B1
公开(公告)日:2001-06-26
申请号:US09066081
申请日:1998-04-24
申请人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
发明人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
IPC分类号: G01N3348
CPC分类号: G01N33/68 , A61K9/1694 , C12Q1/42 , G01N33/491 , G01N33/50 , G01N33/585 , G01N33/587 , G01N33/84 , Y10S436/805 , Y10S436/808 , Y10T428/13 , Y10T428/2982 , Y10T436/101666 , Y10T436/111666
摘要: The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers.
摘要翻译: 本发明提供包含干燥珠粒的干燥化学组合物。 通常,珠粒包含适于分析生物样品的试剂,特别是离心分析仪中血液样品的分析。
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公开(公告)号:US5624597A
公开(公告)日:1997-04-29
申请号:US436670
申请日:1995-05-08
申请人: Steven N. Buhl , Terri Bogart , Tammy Burd , Bhaskar Bhayani , Christian Skieller , Chi-Sou Yu , Thuy N. Tang , Vladimir E. Ostoich , Branko Huc , Carol T. Schembri
发明人: Steven N. Buhl , Terri Bogart , Tammy Burd , Bhaskar Bhayani , Christian Skieller , Chi-Sou Yu , Thuy N. Tang , Vladimir E. Ostoich , Branko Huc , Carol T. Schembri
IPC分类号: C12Q1/32 , A61K9/16 , C12Q1/42 , G01N1/10 , G01N9/30 , G01N21/78 , G01N33/48 , G01N33/483 , G01N33/49 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/58 , G01N33/68 , G01N35/00 , C09K3/00 , G01N31/00
CPC分类号: G01N33/52 , A61K9/1694 , C12Q1/42 , G01N33/491 , G01N33/50 , G01N33/585 , G01N33/68 , Y10S436/805 , Y10S436/808 , Y10T436/10 , Y10T436/111666
摘要: The present invention provides lyophilized reagent spheres comprising reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. Also provided are diluents which are conveniently used in such analyzers.
摘要翻译: 本发明提供了冻干试剂球,其包含适于分析生物样品的试剂,特别是离心分析仪中血液样品的分析。 还提供了在这种分析仪中方便使用的稀释剂。
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公开(公告)号:US5776563A
公开(公告)日:1998-07-07
申请号:US466155
申请日:1995-06-06
申请人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
发明人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
CPC分类号: G01N33/68 , A61K9/1694 , C12Q1/42 , G01N33/491 , G01N33/50 , G01N33/585 , G01N33/587 , G01N33/84 , Y10S436/805 , Y10S436/808 , Y10T428/13 , Y10T428/2982 , Y10T436/101666 , Y10T436/111666
摘要: The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers.
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公开(公告)号:US5413732A
公开(公告)日:1995-05-09
申请号:US747179
申请日:1991-08-19
申请人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
发明人: Steven N. Buhl , Bhaskar Bhayani , Chi-Sou Yu , Thuy N. Tang
IPC分类号: C12Q1/32 , A61K9/16 , C12Q1/42 , G01N1/10 , G01N9/30 , G01N21/78 , G01N33/48 , G01N33/483 , G01N33/49 , G01N33/50 , G01N33/52 , G01N33/53 , G01N33/58 , G01N33/68 , G01N35/00 , C09K3/00 , G01N31/00
CPC分类号: G01N33/52 , A61K9/1694 , C12Q1/42 , G01N33/491 , G01N33/50 , G01N33/585 , G01N33/68 , Y10S436/805 , Y10S436/808 , Y10T436/10 , Y10T436/111666
摘要: The present invention provides lyophilized reagent spheres comprising reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. Also provided are diluents which are conveniently used in such analyzers.
摘要翻译: 本发明提供了冻干试剂球,其包含适于分析生物样品的试剂,特别是离心分析仪中血液样品的分析。 还提供了在这种分析仪中方便使用的稀释剂。
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