公开(公告)号：US08552166B2

公开(公告)日：2013-10-08

申请号：US13116244

申请日：2011-05-26

申请人： Julian Alexander Tanner ,  Ka-To Shum ,  Sze-Lai Celine Chan

发明人： Julian Alexander Tanner ,  Ka-To Shum ,  Sze-Lai Celine Chan

IPC分类号： C07H21/04

CPC分类号： A61K31/711 ,  A61K31/7125 ,  C12N15/115 ,  C12N2310/16

摘要： Described are nucleic acid aptamers that are able to bind to and inhibit the function of sclerostin, which is an important negative regulator of bone growth. The aptamers have application as therapeutics for diseases of bone including osteoporosis, osteopenia, osteoarthritis and other osteoporosis-related conditions and complications.

摘要翻译： 描述了能够结合并抑制作为骨生长的重要负调节因子的硬化蛋白的功能的核酸适体。 适体作为骨质疏松症，骨质减少症，骨关节炎等骨质疏松症相关病症和并发症的骨疾病治疗药物。

公开(公告)号：US20110294872A1

公开(公告)日：2011-12-01

申请号：US13116244

申请日：2011-05-26

申请人： Julian Alexander Tanner ,  Ka-To Shum ,  Sze-Lai Celine Chan

发明人： Julian Alexander Tanner ,  Ka-To Shum ,  Sze-Lai Celine Chan

IPC分类号： A61K31/7088 ,  A61P19/08 ,  A61P19/10 ,  C07H21/04

CPC分类号： A61K31/711 ,  A61K31/7125 ,  C12N15/115 ,  C12N2310/16

摘要： Described are nucleic acid aptamers that are able to bind to and inhibit the function of sclerostin, which is an important negative regulator of bone growth. The aptamers have application as therapeutics for diseases of bone including osteoporosis, osteopenia, osteoarthritis and other osteoporosis-related conditions and complications.

摘要翻译： 描述了能够结合并抑制作为骨生长的重要负调节因子的硬化蛋白的功能的核酸适体。 适体作为骨质疏松症，骨质减少症，骨关节炎等骨质疏松症相关病症和并发症的骨疾病治疗药物。