公开(公告)号：US20250064633A1

公开(公告)日：2025-02-27

申请号：US18664174

申请日：2024-05-14

Applicant: The Regents of the University of Colorado, a body Corporate

Inventor： Andrew Schieber ,  Linda Thai ,  Malik Kahook

IPC: A61F9/00 ,  A61K9/00 ,  A61K45/00

Abstract: A lacrimal drug delivery device includes a reservoir configured to hold a drug. The reservoir is moveable between a relaxed state and an expanded state. A connector is fluidly coupled to the reservoir and a lumen is formed in the connector wherein the drug is configured to flow from the reservoir to a delivery site through the lumen. A hydrogel is within the lumen and configured to absorb the drug from the reservoir and deliver the drug from the lumen at the delivery site. The hydrogel includes a first section which absorbs the drug at a first rate of absorption. A delivery guide is detachably coupled to the reservoir to deliver the reservoir into a lacrimal sac of a patient.

公开(公告)号：US20250051913A1

公开(公告)日：2025-02-13

申请号：US18801284

申请日：2024-08-12

Applicant: VitriVax, Inc. ,  The Regents of the University of Colorado, a body corporate

Inventor： Hans Heinrich Funke

IPC: C23C16/455 ,  C23C16/44 ,  C23C16/442

Abstract: Embodiments disclosed herein relate to a modified reactor system for creating coated particles of thermostable agents having reduced loss and improved coating uniformity due to avoidance of adherence of the particles to the reactor or to other particles. In certain embodiments, a reactor system includes a reactor vessel configured to receive particles of thermostable agents, and one or more agitating appendages or devices, including at least one of ultrasonic agitator, mechanical impactor, and low-frequency vibrator either directly connected or in fluid communication with the reactor system for sonicating, impacting, or vibrating a reactor vessel during the particle coating process. In some embodiments, the reactor system includes a gas phase dosing system configured to introduce alternating pulses of chemically gas phase materials into the reactor vessel to form a coating on the particles while continuously or intermittently agitating the reactor system.

公开(公告)号：US20250034551A1

公开(公告)日：2025-01-30

申请号：US18707093

申请日：2022-11-03

Applicant: THINK BIOSCIENCE, INC. ,  THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Nolan O'CONNOR ,  Andrew MARKLEY ,  Hannah EDSTROM ,  Jerome Michael FOX ,  Tommaso Antonio FODERARO ,  Ankur Kulshreshtha SARKAR ,  Matthew TRAYLOR ,  Levi Daniel KRAMER ,  Gregory DONOVAN

IPC: C12N15/10 ,  C12N9/12 ,  C12N9/88 ,  C12Q1/6853 ,  C12Q1/6869 ,  G01N33/50

Abstract: Provided are high-throughput screens for biologically active modulators of a target enzyme that mimic or recreate natural processes of diversification and selection. In some embodiments, the platform comprises one or more expression systems including without limitation (i) a two-hybrid system that, when expressed in a cell, links survival of the cell to the modulation of a therapeutic target, and (ii) a metabolic system that enables the biosynthesis of structurally varied modulators of the therapeutic agent.

公开(公告)号：US12196627B2

公开(公告)日：2025-01-14

申请号：US17574880

申请日：2022-01-13

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jianliang Xiao ,  Wei Zhang ,  Chuanqian Shi

IPC: G01L1/22 ,  A61B5/00 ,  G01L1/20

Abstract: The present disclosure provides a high-performance integrated strain sensing device that is highly stretchable, rehealable, recyclable and reconfigurable. This device can include dynamic covalent thermoset polyimine as the substrate and encapsulation, eutectic liquid metal alloy as the strain sensing unit and interconnects, and off-the-shelf chip components for measuring and magnifying functions. The device can be attached on the knee, elbow, wrist and finger joints for strain sensing and motion monitoring, and can also be attached on the abdomen to accurately measure respiration cycles.

公开(公告)号：US20250000955A1

公开(公告)日：2025-01-02

申请号：US18614952

申请日：2024-03-25

Applicant: The Regents of the University of Colorado, A Body Corporate

Inventor： V. Michael Holers ,  Nirmal Banda ,  Liudmila Kulik

IPC: A61K38/48 ,  A01K67/027 ,  A61K38/00 ,  A61K48/00 ,  C07K16/18 ,  C07K16/44 ,  C12N9/64

Abstract: The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation, where it inhibits the lectin pathway of complement activation.

公开(公告)号：US20240424673A1

公开(公告)日：2024-12-26

申请号：US18668453

申请日：2024-05-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Daniel Szafir ,  Michael E. Walker ,  Hooman Hedayati

IPC: B25J9/16 ,  B25J13/06 ,  G06F3/14 ,  G06T11/00 ,  G06V20/10

Abstract: Systems and methods for human-robot communication. More particularly, some embodiments use augmented reality to facilitate communication of robot intention and teleoperation in human-robot cooperative environments. Various embodiments of the present technology provide a middleware that integrates augmented reality (AR) with novel teleoperation interfaces to increase operation effectiveness, support the user in conducting concurrent work, and decrease stress. Various embodiments provide predictive graphical interfaces such that a teleoperator controls a virtual robot surrogate, rather than directly operating the robot itself, providing the user with foresight regarding where the physical robot will end up and how it will get there. In accordance with various embodiments a user may select between two AR interfaces using such a surrogate: one focused on real-time control and one inspired by waypoint delegation.

公开(公告)号：US12166623B2

公开(公告)日：2024-12-10

申请号：US18249580

申请日：2021-10-18

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Yang Wang ,  Yu T. Morton

IPC: H04L27/38 ,  H04L27/00

Abstract: DLOS and reflected signal components of an RF carrier signal are received. The reflected component is reflected from a point on the surface of the earth. The DLOS and reflected components are converted to digital DLOS IF and reflected IF signals, respectively. Modeled parameters are generated using the digital DLOS IF signal and locations of one or more antennas, the transmitter, and the point. A reference signal is generated based on the modeled parameters. The reference signal is correlated with the digital reflected IF signal to produce in-phase and quadrature-phase correlation results. A C/N0 and an estimated phase (EP) are calculated for the digital reflected IF signal from the correlation results. A KF is applied to the EP to produce an estimated filter phase (EFP). The KF is adapted to filter the EP using the estimated C/N0 to reduce cycle slips and noise in the EFP.

公开(公告)号：US20240382385A1

公开(公告)日：2024-11-21

申请号：US18765795

申请日：2024-07-08

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Adam Green ,  Steven Lammers ,  Jennifer Wagner ,  Ken Liechty ,  Jahmel Jordon

IPC: A61J15/00

Abstract: A feeding tube configured to allow intact pills to pass through an internal lumen of the feeding tube. Some embodiments of the feeding tube include a main body having a lumen extending between a proximal end and a distal end of the main body. The proximal end includes an inlet aperture leading to the lumen and the distal end includes an outlet aperture fluidically coupled to the lumen. The main body includes a thin-walled transcutaneous section configured to temporarily receive a tubular structural support member that can operate as a traditional feeding tube. The tubular structural support member can be removed to allow a pill delivery device to deliver an intact pill through the lumen and out of the outlet aperture.

公开(公告)号：US12070216B2

公开(公告)日：2024-08-27

申请号：US17845700

申请日：2022-06-21

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Max Bannister Mitchell ,  Alexander Travis Brown

IPC: A61B17/11 ,  A61M60/148 ,  A61M60/178 ,  A61M60/863

CPC classification number: A61B17/11 ,  A61M60/148 ,  A61M60/178 ,  A61M60/863 ,  A61B2017/1107 ,  A61M2205/0216

Abstract: An implantable anastomotic assembly, which is configured to be attached to cardiovascular tissue, includes a connection interface, a plurality of outer plates, and a plurality of connectors configured to extend between and interconnect the connection interface and the plurality of outer plates, respectively, according to various embodiments. The connection interface is separate from and non-contiguous with the plurality of outer plates, according to various embodiments.

公开(公告)号：US20240245049A1

公开(公告)日：2024-07-25

申请号：US18627309

申请日：2024-04-04

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Marc MATHIAS ,  Kang LI ,  Miguel FLORES BELLVER ,  Silvia APARICIO DOMINGO ,  Conan CHEN ,  Valeria CANTO-SOLER

IPC: A01N1/02 ,  A61F9/00 ,  A61K35/30

CPC classification number: A01N1/0263 ,  A61F9/0017 ,  A61K35/30

Abstract: A cell transplant carrier including a carrier plate and a carrier housing. The carrier plate includes a body and one or more chambers defined in the body. Each of the one or more chambers is configured to receive a cell transplant and is shaped to cause the cell transplant to be at least partially exposed in order to permit removal of the cell transplant therefrom. The carrier housing includes a carrier plate opening leading to an inner compartment configured to removably receive the carrier plate.