公开(公告)号：US20090312251A1

公开(公告)日：2009-12-17

申请号：US12412496

申请日：2009-03-27

Applicant: Dae-Sik Lim ,  Joo-Hyeon Lee ,  Tae-Shin Kim ,  Tae-Hong Yang ,  Bon-Kyoung Koo ,  Sang-Phil Oh ,  Kwang-Pyo Lee ,  Hyun-Jung Oh ,  Sang-Hee Lee ,  Young-Yun Kong ,  Jin-Man Kim

Inventor： Dae-Sik Lim ,  Joo-Hyeon Lee ,  Tae-Shin Kim ,  Tae-Hong Yang ,  Bon-Kyoung Koo ,  Sang-Phil Oh ,  Kwang-Pyo Lee ,  Hyun-Jung Oh ,  Sang-Hee Lee ,  Young-Yun Kong ,  Jin-Man Kim

IPC: A61K38/17 ,  A61K31/711 ,  A01K67/027 ,  C12N5/10 ,  A61P35/00 ,  C12Q1/68 ,  A61K38/16

CPC classification number: G01N33/5011 ,  C12N5/0629 ,  C12N2501/405 ,  G01N33/5088

Abstract: Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation regulators, methods of regulating differentiation, transgenic organisms with loss of expression of the differentiation regulator, and methods of preparing the transgenic organisms, are provided.

Abstract translation: 介绍了在哺乳动物胚胎发育阶段调节细胞增殖停止和分化起始的机制及其中涉及的蛋白质。 提供了分化调节剂，调节分化的方法，丧失表达分化调节剂的转基因生物以及制备转基因生物的方法。

公开(公告)号：US08076532B2

公开(公告)日：2011-12-13

申请号：US12412496

申请日：2009-03-27

Applicant: Dae-Sik Lim ,  Joo-Hyeon Lee ,  Tae-Shin Kim ,  Tae-Hong Yang ,  Bon-Kyoung Koo ,  Sang-Phil Oh ,  Kwang-Pyo Lee ,  Hyun-Jung Oh ,  Sang-Hee Lee ,  Young-Yun Kong ,  Jin-Man Kim

Inventor： Dae-Sik Lim ,  Joo-Hyeon Lee ,  Tae-Shin Kim ,  Tae-Hong Yang ,  Bon-Kyoung Koo ,  Sang-Phil Oh ,  Kwang-Pyo Lee ,  Hyun-Jung Oh ,  Sang-Hee Lee ,  Young-Yun Kong ,  Jin-Man Kim

IPC: A01K67/027 ,  A01K67/00 ,  A01K67/033 ,  G01N33/00

CPC classification number: G01N33/5011 ,  C12N5/0629 ,  C12N2501/405 ,  G01N33/5088

Abstract: Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation regulators, methods of regulating differentiation, transgenic organisms with loss of expression of the differentiation regulator, and methods of preparing the transgenic organisms, are provided.

Abstract translation: 介绍了在哺乳动物胚胎发育阶段调节细胞增殖停止和分化起始的机制及其中涉及的蛋白质。 提供了分化调节剂，调节分化的方法，丧失表达分化调节剂的转基因生物以及制备转基因生物的方法。