公开(公告)号：US09572834B2

公开(公告)日：2017-02-21

申请号：US14114007

申请日：2012-04-26

申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

IPC分类号： A61K31/335 ,  A61K9/00 ,  A61K38/00 ,  A61K47/00 ,  A61K33/44 ,  B82Y5/00 ,  A61K45/06 ,  A61K47/48 ,  A61K31/713

CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

公开(公告)号：US20140120081A1

公开(公告)日：2014-05-01

申请号：US14114007

申请日：2012-04-26

申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

IPC分类号： A61K33/44 ,  A61K45/06 ,  A61K47/48

CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。