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    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress
    1.
    发明授权
    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress 有权
    使用具有抗氧化性能的碳纳米材料来治疗氧化应激

    公开(公告)号：US09572834B2

    公开(公告)日：2017-02-21

    申请号：US14114007

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    IPC分类号： A61K31/335 ,  A61K9/00 ,  A61K38/00 ,  A61K47/00 ,  A61K33/44 ,  B82Y5/00 ,  A61K45/06 ,  A61K47/48 ,  A61K31/713

    CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

    摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

    摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

    USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS
    2.
    发明申请
    USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS 有权
    使用碳纳米微粒与抗氧化性能来处理氧化应激

    公开(公告)号：US20140120081A1

    公开(公告)日：2014-05-01

    申请号：US14114007

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    IPC分类号： A61K33/44 ,  A61K45/06 ,  A61K47/48

    CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

    摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

    摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

    TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS
    3.
    发明申请
    TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS 审中-公开
    目标纳米颗粒及其用于治疗脑肿瘤的用途

    公开(公告)号：US20140154269A1

    公开(公告)日：2014-06-05

    申请号：US14114051

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  David S. Baskin ,  Martyn A. Sharpe

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  David S. Baskin ,  Martyn A. Sharpe

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0085 ,  A61K9/5123 ,  A61K47/60 ,  A61K47/6925 ,  C12N15/87 ,  C12N2810/859

    摘要： In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.

    摘要翻译： 在一些实施方案中，本发明涉及用于治疗脑肿瘤的治疗组合物。 这样的治疗组合物通常包括：（1）纳维酮; （2）与具有针对脑肿瘤细胞活性的纳米动物相关的活性剂; 和（3）与具有脑肿瘤细胞标志物的识别活性的纳米动物相关的靶向剂。 在一些实施方案中，活性剂和靶向剂与纳米活性剂非共价缔合。 本发明的另外的实施方案涉及通过将上述治疗组合物给予受试者来治疗受试者（例如，人）中的脑肿瘤的方法。 本公开的另外的实施方案涉及以个性化方式配制用于治疗受试者的脑肿瘤的治疗组合物的方法。

    Solvent-based methods for production of graphene nanoribbons
    10.
    发明授权
    Solvent-based methods for production of graphene nanoribbons 有权
    用于生产石墨烯纳米带的基于溶剂的方法

    公开(公告)号：US09493355B2

    公开(公告)日：2016-11-15

    申请号：US14345016

    申请日：2012-09-14

    申请人： James M. Tour ,  Wei Lu ,  Bostjan Genorio

    发明人： James M. Tour ,  Wei Lu ,  Bostjan Genorio

    IPC分类号： C01B31/02 ,  C07C29/32 ,  C08F112/08 ,  C01B31/04

    CPC分类号： C08F112/08 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B32/178 ,  C01B32/18 ,  C01B32/184 ,  C01B32/194 ,  C01B2202/06 ,  C01B2204/06 ,  C07C2/76 ,  C07C15/56 ,  C07C29/32 ,  C07C67/035 ,  C07C69/76 ,  D01F9/12 ,  Y10S977/734 ,  Y10S977/846 ,  Y10S977/961

    摘要： The present invention provides methods of preparing functionalized graphene nanoribbons. Such methods include: (1) exposing a plurality of carbon nanotubes (CNTs) to an alkali metal source in the presence of an aprotic solvent to open them; and (2) exposing the opened CNTs to an electrophile to form functionalized graphene nanoribbons (GNRs). The methods may also include a step of exposing the opened CNTs to a protic solvent to quench any reactive species on them. Additional methods include preparing unfunctionalized GNRs by: (1) exposing a plurality of CNTs to an alkali metal source in the presence of an aprotic solvent to open them; and (2) exposing the opened CNTs to a protic solvent to form unfunctionalized GNRs.

    摘要翻译： 本发明提供了制备官能化石墨烯纳米带的方法。 这些方法包括：（1）在非质子溶剂的存在下将多个碳纳米管（CNT）暴露于碱金属源以将其打开; 和（2）将开放的CNT暴露于亲电子试剂以形成官能化的石墨烯纳米带（GNR）。 所述方法还可以包括将开放的CNT暴露于质子溶剂以淬灭其上的任何反应性物质的步骤。 另外的方法包括：通过以下步骤制备未官能化的GNR：（1）在非质子溶剂存在下将多个CNT暴露于碱金属源以打开它们; 和（2）将开放的CNT暴露于质子溶剂以形成未官能化的GNR。