公开(公告)号：US20060275905A1

公开(公告)日：2006-12-07

申请号：US11189065

申请日：2005-07-25

Applicant: Taeok Bae ,  Fredrik Aslund ,  Olaf Schneewind ,  Dominique Missiakas

Inventor： Taeok Bae ,  Fredrik Aslund ,  Olaf Schneewind ,  Dominique Missiakas

IPC: A61K49/00 ,  C12N15/74 ,  C12N1/21

CPC classification number: A61K49/00 ,  C12N1/20 ,  C12N9/22 ,  C12N15/74

Abstract: The present invention concerns gram positive bacterial mutants, particularly staphylococcus mutants of the Newman strain. It also involves transposable elements that can be used to generate these mutants, as well as methods of creating such mutants with these elements. The inventions also includes methods of using the bacterial mutants to screen for different types of genes, including virulence genes, which can lead to assays for drug compounds useful in the treatment of bacterial infection.

Abstract translation: 本发明涉及革兰氏阳性细菌突变体，特别是Newman菌株的葡萄球菌突变体。 它还涉及可用于产生这些突变体的转座元件，以及用这些元件产生这种突变体的方法。 本发明还包括使用细菌突变体筛选不同类型的基因（包括毒力基因）的方法，其可以导致用于治疗细菌感染的药物化合物的测定。