公开(公告)号：US06455555B1

公开(公告)日：2002-09-24

申请号：US09868742

申请日：2001-06-20

申请人： Yoshinori Nakagawa ,  Takehiro Niiyama ,  Satoshi Tsuboi

发明人： Yoshinori Nakagawa ,  Takehiro Niiyama ,  Satoshi Tsuboi

IPC分类号： A61K314418

CPC分类号： C07D215/12 ,  A61K31/427 ,  A61K31/4709 ,  A61K41/0009

摘要： The present invention relates to agents for anti-HIV infection, which contain, as an active ingredient, at least one photosensitizing dye selected from the group consisting of the compounds of the formulae (I) and (II): wherein R1, R2 and R3 are the same or different and each represents alkyl group having 1 to 4 carbon atoms, R4, R5 and R6 are the same or different and each represents alkyl group having 5 to 10 carbon atoms, and X− represents a physiologically acceptable monovalent anion. The present invention also relates to a method for treating or preventing HIV infection diseases, which includes administering the photosensitizing dye. A daily dose of the photosensitizing dye is usually 2 to 100 &mgr;g, and preferably 5 to 40 &mgr;g, per kg body weight. Administration of the photosensitizing dye to HIV infected subjects leads to improvement or cure of the symptoms of AIDS related complex and increase in CD4-positive lymphocytes, which is effective for the treatment of HIV infection diseases.

摘要翻译： 本发明涉及抗HIV感染剂，其含有选自由式（I）和（II）的化合物组成的组中的至少一种光敏染料作为活性成分：其中R1，R2和R3 各自表示具有1〜4个碳原子的烷基，R 4，R 5和R 6相同或不同，表示具有5〜10个碳原子的烷基，X表示生理上可接受的一价阴离子。 本发明还涉及治疗或预防HIV感染疾病的方法，其包括施用感光染料。 光敏染料的日剂量通常为每kg体重2至100杯，优选5至40杯。 将感染染料施用于HIV感染的受试者导致改善或治愈AIDS相关复合物的症状并增加CD4阳性淋巴细胞，这对于治疗HIV感染疾病是有效的。