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    Anti-HIV infection agents and method for treating HIV infection
    2.
    发明授权
    Anti-HIV infection agents and method for treating HIV infection 有权
    抗HIV感染剂和治疗HIV感染的方法

    公开(公告)号：US06455555B1

    公开(公告)日：2002-09-24

    申请号：US09868742

    申请日：2001-06-20

    申请人： Yoshinori Nakagawa ,  Takehiro Niiyama ,  Satoshi Tsuboi

    发明人： Yoshinori Nakagawa ,  Takehiro Niiyama ,  Satoshi Tsuboi

    IPC分类号： A61K314418

    CPC分类号： C07D215/12 ,  A61K31/427 ,  A61K31/4709 ,  A61K41/0009

    摘要： The present invention relates to agents for anti-HIV infection, which contain, as an active ingredient, at least one photosensitizing dye selected from the group consisting of the compounds of the formulae (I) and (II): wherein R1, R2 and R3 are the same or different and each represents alkyl group having 1 to 4 carbon atoms, R4, R5 and R6 are the same or different and each represents alkyl group having 5 to 10 carbon atoms, and X− represents a physiologically acceptable monovalent anion. The present invention also relates to a method for treating or preventing HIV infection diseases, which includes administering the photosensitizing dye. A daily dose of the photosensitizing dye is usually 2 to 100 &mgr;g, and preferably 5 to 40 &mgr;g, per kg body weight. Administration of the photosensitizing dye to HIV infected subjects leads to improvement or cure of the symptoms of AIDS related complex and increase in CD4-positive lymphocytes, which is effective for the treatment of HIV infection diseases.

    摘要翻译： 本发明涉及抗HIV感染剂，其含有选自由式（I）和（II）的化合物组成的组中的至少一种光敏染料作为活性成分：其中R1，R2和R3 各自表示具有1〜4个碳原子的烷基，R 4，R 5和R 6相同或不同，表示具有5〜10个碳原子的烷基，X表示生理上可接受的一价阴离子。 本发明还涉及治疗或预防HIV感染疾病的方法，其包括施用感光染料。 光敏染料的日剂量通常为每kg体重2至100杯，优选5至40杯。 将感染染料施用于HIV感染的受试者导致改善或治愈AIDS相关复合物的症状并增加CD4阳性淋巴细胞，这对于治疗HIV感染疾病是有效的。

    Inhibitors of protein isoprenyl transferases
    7.
    发明授权
    Inhibitors of protein isoprenyl transferases 失效
    蛋白质异戊二烯转移酶抑制剂

    公开(公告)号：US06277871B1

    公开(公告)日：2001-08-21

    申请号：US09442687

    申请日：1999-11-18

    申请人： Stephen J. O'Connor ,  Lissa T. J. Nelson

    发明人： Stephen J. O'Connor ,  Lissa T. J. Nelson

    IPC分类号： A61K314418

    CPC分类号： C07D401/06 ,  C07D211/78 ,  C07D405/04 ,  C07D417/12 ,  C07D417/14

    摘要： The present invention relates to novel compounds of Formula I which are useful in inhibiting protein isoprenyl transferases and the farnesylation or geranylgeranylation of the oncogene protein Ras and other related small g-proteins, and compositions containing such compounds and methods of using such compounds.

    摘要翻译： 本发明涉及可用于抑制蛋白质异戊二烯基转移酶和癌基因蛋白Ras和其他相关小g-蛋白质的法呢基化或er牛儿基基化的式I的新化合物，以及含有这些化合物的组合物和使用这些化合物的方法。

    1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety
    8.
    发明授权
    1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety 失效
    1,4-二氢吡啶衍生物与愈创木酚丙醇胺和/或苯氧基丙醇胺部分

    公开(公告)号：US06794399B2

    公开(公告)日：2004-09-21

    申请号：US10119709

    申请日：2002-04-11

    申请人： Ing-Jun Chen

    发明人： Ing-Jun Chen

    IPC分类号： A61K314418

    CPC分类号： C07D211/90

    摘要： The invention disclosed some 1,4-dihydropiridine derivative chemically with guaiacoxypropanolamine based phenoxypropanolamine moiety and pharmacologically with &bgr;-adrenoceptor blocking and partial &bgr;2-agonist activities, is now emerging. The compound of 1,4-dihydropiridine derivative wherein has the formula I, wherein R selected from four group as follow R1 selected from X, H, NO2 saturated C1-C6 alkyl chain, unsaturated C6-C6 alkyl chain, R2 selected from H, CH3 R3 and R4 are individually selected from saturated C1-C6 alkyl chain, unsaturated C1-C6 alkyl chain; R5 selected from OH, saturated C1-C6 alkyl chain, unsaturated C1-C6 alkyl chain.

    摘要翻译： 本发明公开了一些以愈创木酚氧丙醇胺为基础的苯氧基丙胺胺部分化学发现的1,4-二氢吡啶衍生物，其药理学上具有β-肾上腺素能受体阻断和部分β2-激动剂活性。目前正在出现1,4-二氢嘧啶衍生物，其中式Ⅰ化合物，其中 选自X，H，NO 2饱和C 1 -C 6烷基链，不饱和C 6 -C 6烷基链，选自H，CH 3 R 3和R 4的R 4的四个R中的R选自饱和C 1 -C 6烷基链，不饱和C 1 -C 6烷基链， C6烷基链; R5选自OH，饱和C1-C6烷基链，不饱和C1-C6烷基链。