公开(公告)号：US5583227A

公开(公告)日：1996-12-10

申请号：US458871

申请日：1995-06-02

申请人： Takeshi Niho ,  Ichiro Yamamoto ,  Hidenori Mochizuki ,  Ikuo Kimura ,  Akihiro Imai ,  Tetsuyuki Nakase

发明人： Takeshi Niho ,  Ichiro Yamamoto ,  Hidenori Mochizuki ,  Ikuo Kimura ,  Akihiro Imai ,  Tetsuyuki Nakase

IPC分类号： C07D241/24 ,  C07D241/42 ,  C07D241/44 ,  A61K31/33

CPC分类号： C07D241/24 ,  C07D241/42 ,  C07D241/44

摘要： This invention relates to a novel compound which is useful as a drug in preventing and/or treating peptic ulcer-related diseases, to a production process thereof and to a pharmaceutical composition containing the same.Particularly, it provides a compound which has a specified substituted alkynylpyrazine nucleus or a specified substituted alkynylquinoxaline nucleus, represented by the following formula (I) ##STR1## wherein A is represented by the following formula (II) or (III) ##STR2## and R.sup.1 is represented by the following formula (IV), ##STR3## and the salts thereof, a production process thereof and a pharmaceutical composition containing the same.The inventive compound is useful as a drug in preventing and/or treating peptic ulcer-related diseases.

摘要翻译： 本发明涉及可用作预防和/或治疗消化性溃疡相关疾病的药物的新型化合物及其制备方法和含有该化合物的药物组合物。 特别地，其提供具有指定的取代的炔基吡嗪核的化合物或由下式（I）表示的特定的取代的炔基喹喔啉核，其中A由下式（II）或（III）表示： （II）＆lt; IMAGE＆gt;（III），R1由下式（Ⅳ），ⅩⅧ及其盐表示，其制备方法和含有该化合物的药物组合物。 本发明化合物可用作预防和/或治疗消化性溃疡相关疾病的药物。