公开(公告)号：US07342116B2

公开(公告)日：2008-03-11

申请号：US10509228

申请日：2003-03-25

申请人： Yasuhiro Shiomi ,  Osamu Uno ,  Akio Ohta ,  Takeshi Sunakami

发明人： Yasuhiro Shiomi ,  Osamu Uno ,  Akio Ohta ,  Takeshi Sunakami

IPC分类号： C07D211/70 ,  C07D333/22

CPC分类号： C07D213/48

摘要： A process is disclosed for preparing a heterocyclic aldehyde by oxidizing a heterocyclic alcohol with high selectivity and high yield. Specifically, the heterocyclic aldehyde is prepared by reacting a heterocyclic compound having at least one hydroxymethyl group bonded to a carbon atom of a heterocyclic ring with a hypohalogenous acid salt in the presence of a base to oxidize the hydroxymethyl group, wherein reaction is conducted in the co-presence of a 2,2,6,6-tetramethylpiperidine-1-oxyl derivative having at least two 2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl groups.

摘要翻译： 公开了通过以高选择性和高产率氧化杂环醇制备杂环醛的方法。 具体地说，杂环醛通过在碱的存在下使具有至少一个羟基甲基与杂环的碳原子键合的杂环化合物与低级卤酸酸盐反应来制备，以氧化羟甲基，其中反应在 具有至少两个2,2,6,6-四甲基哌啶-1-氧基-4-基的2,2,6,6-四甲基哌啶-1-氧基衍生物的共存。

公开(公告)号：US20050124807A1

公开(公告)日：2005-06-09

申请号：US10509228

申请日：2003-03-25

申请人： Yasuhiro Shiomi ,  Osamu Uno ,  Akio Ohta ,  Takeshi Sunakami

发明人： Yasuhiro Shiomi ,  Osamu Uno ,  Akio Ohta ,  Takeshi Sunakami

IPC分类号： C07D213/48 ,  C07D333/18 ,  C07D213/46 ,  C07D241/02

CPC分类号： C07D213/48

摘要： The present invention provides a process for preparing a heterocyclic aldehyde by oxidizing a heterocyclic alcohol with high selectivity and high yield. Specifically, the heterocyclic aldehyde is prepared by reacting a heterocyclic compound having at least one hydroxymethyl group bonded to a carbon atom of a heterocyclic ring with a hypohalogenous acid salt in the presence of a base to oxidize the hydroxymethyl group, wherein reaction is conducted in the co-presence of a 2,2,6,6-tetramethylpiperidine-1-oxyl derivative having at least two 2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl groups.

摘要翻译： 本发明提供了通过以高选择性和高收率氧化杂环醇制备杂环醛的方法。 具体地说，杂环醛通过使具有至少一个羟基甲基与杂环的碳原子键合的杂环化合物与低级卤酸酸盐在碱的存在下反应来制备，以氧化羟甲基，其中反应在 具有至少两个2,2,6,6-四甲基哌啶-1-氧基-4-基的2,2,6,6-四甲基哌啶-1-氧基衍生物的共存。