公开(公告)号：US07871980B2

公开(公告)日：2011-01-18

申请号：US11988028

申请日：2006-06-30

申请人： Chise Mukaidani ,  Katsutoshi Yoshizato ,  Norio Masumoto ,  Miho Kataoka ,  Tatsuhiko Tsunoda ,  Fuyuki Miya

发明人： Chise Mukaidani ,  Katsutoshi Yoshizato ,  Norio Masumoto ,  Miho Kataoka ,  Tatsuhiko Tsunoda ,  Fuyuki Miya

IPC分类号： C12N5/08 ,  A01N63/00 ,  A61K38/27

CPC分类号： A61K38/27 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2227/105 ,  A01K2267/03 ,  A61K35/407 ,  C12N9/6424

摘要： Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes.

摘要翻译： 将人成年肝细胞移植到免疫缺陷型肝病小鼠中，然后向小鼠施用人生长激素，从而通过移植的人成年肝细胞提升两倍以上的置换率。 此外，将人生长激素施用于携带人类年轻肝细胞的免疫缺陷型肝病小鼠，以改善其中约70％或更多的肝细胞已被人肝细胞代替的小鼠的脂肪肝。

公开(公告)号：US20090060882A1

公开(公告)日：2009-03-05

申请号：US11988028

申请日：2006-06-30

申请人： Chise Mukaidani ,  Katsutoshi Yoshizato ,  Norio Masumoto ,  Miho Kataoka ,  Tatsuhiko Tsunoda ,  Fuyuki Miya

发明人： Chise Mukaidani ,  Katsutoshi Yoshizato ,  Norio Masumoto ,  Miho Kataoka ,  Tatsuhiko Tsunoda ,  Fuyuki Miya

IPC分类号： A61K45/00 ,  A61P1/16

CPC分类号： A61K38/27 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2227/105 ,  A01K2267/03 ,  A61K35/407 ,  C12N9/6424

摘要： Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes.

摘要翻译： 将人成年肝细胞移植到免疫缺陷型肝病小鼠中，然后向小鼠施用人生长激素，从而通过移植的人成年肝细胞提升两倍以上的置换率。 此外，将人生长激素施用于携带人类年轻肝细胞的免疫缺陷型肝病小鼠，以改善其中约70％或更多的肝细胞已被人肝细胞代替的小鼠的脂肪肝。