公开(公告)号：US06461633B1

公开(公告)日：2002-10-08

申请号：US09463309

申请日：2000-01-24

申请人： Keiichi Kawakami ,  Katsushi Watanabe ,  Teru Nakai ,  Katsumi Uei ,  Aya Bandou ,  Tatsuya Ishii ,  Yuki Hirata ,  Takashi Fujimoto

发明人： Keiichi Kawakami ,  Katsushi Watanabe ,  Teru Nakai ,  Katsumi Uei ,  Aya Bandou ,  Tatsuya Ishii ,  Yuki Hirata ,  Takashi Fujimoto

IPC分类号： A61K4700

CPC分类号： A23L33/12

摘要： The invention provides a reducing sugar-containing fat emulsion comprising an oil-in-water fat emulsion available upon emulsification of a fat with an emulsifier wherein a reducing sugar and at least one buffer substance selected from among organic acids with acid dissociation exponents in water within the range of 5.0-7.5 and their salts are concurrently contained in the water phase thereof, with the emulsion having been adjusted to pH 5.0-7.5; a reducing sugar-containing fat emulsion product which comprises a medicinal fluid containing a reducing sugar and a fat as sterilized with carbon dioxide gas dissolved therein and contained in a plastic infusion container, said plastic infusion container being accommodated together with a carbon dioxide gas absorber in a substantially oxygen-impermeable secondary container; and a method for their preparation and sterilization. The reducing sugar-containing fat emulsion is stable and of high quality, because it is inhibited against formation of free fatty acids, decomposition of the reducing sugar, and hence coloration.

摘要翻译： 本发明提供一种含还原糖的脂肪乳剂，其包含在用乳化剂乳化脂肪时可获得的水包油型脂肪乳剂，其中还原糖和选自有机酸中的至少一种缓冲物质，在水中具有酸解离指数 在其水相中同时含有5.0-7.5的范围及其盐，将乳液调节至pH5.0-7.5; 含有还原糖的脂肪乳液产品，其包含含有还原糖和脂肪的药液，所述药液用溶解在其中的二氧化碳气体灭菌并包含在塑料输注容器中，所述塑料输注容器与二氧化碳气体吸收器一起容纳 基本上不透氧的次级容器; 及其制备和灭菌方法。 含还原糖的脂肪乳液是稳定的和高质量的，因为它被抑制游离脂肪酸的形成，还原糖的分解和着色。