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公开(公告)号：US09018362B2
公开(公告)日：2015-04-28
申请号：US13819954
申请日：2011-07-22
申请人： Hiroyuki Asanuma , Xingguo Liang , Hiromu Kashida , Hidenori Nishioka , Taiga Fujii , Teruchika Ishikawa
发明人： Hiroyuki Asanuma , Xingguo Liang , Hiromu Kashida , Hidenori Nishioka , Taiga Fujii , Teruchika Ishikawa
摘要： Provided is an oligonucleotide containing an azobenzene derivative, represented by Formula (1) or (2) below: (in the formulae, A1 and A2 each independently represent a hydrogen atom, nucleotide or oligonucleotide, B1 and B2 each independently represent a hydroxyl group, nucleotide or oligonucleotide, R11 and R12 each independently represent a C1-20 alkyl group, R21 and R22 each independently represent a hydrogen atom or C1-20 alkyl group, and R13 to R18 and R23 to R28 each independently represent a hydrogen atom; a C1-20 alkyl group or alkoxy group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a C2-20 alkenyl group or alkynyl group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a hydroxyl group; a halogen atom; an amino group; a nitro group; or a carboxyl group).
摘要翻译： 本发明提供含有式（1）或（2）表示的偶氮苯衍生物的寡核苷酸：（式中，A1和A2各自独立地表示氢原子，核苷酸或寡核苷酸，B1和B2各自独立地表示羟基， 核苷酸或寡核苷酸，R 11和R 12各自独立地表示C 1-20烷基，R 21和R 22各自独立地表示氢原子或C 1-20烷基，R 13〜R 18和R 23〜R 28各自独立地表示氢原子; C1 -20任选被卤素原子，羟基，氨基，硝基或羧基取代的烷基或烷氧基;任选被卤素原子取代的C 2-20烯基或炔基，羟基，氨基，硝基 或羧基;羟基;卤素原子;氨基，硝基或羧基）。
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公开(公告)号：US20130225797A1
公开(公告)日：2013-08-29
申请号：US13819954
申请日：2011-07-22
申请人： Hiroyuki Asanuma , Xingguo Liang , Hiromu Kashida , Hidenori Nishioka , Taiga Fujii , Teruchika Ishikawa
发明人： Hiroyuki Asanuma , Xingguo Liang , Hiromu Kashida , Hidenori Nishioka , Taiga Fujii , Teruchika Ishikawa
摘要： Provided is an oligonucleotide containing an azobenzene derivative, represented by Formula (1) or (2) below: (in the formulae, A1 and A2 each independently represent a hydrogen atom, nucleotide or oligonucleotide, B1 and B2 each independently represent a hydroxyl group, nucleotide or oligonucleotide, R11 and R12 each independently represent a C1-20 alkyl group, R21 and R22 each independently represent a hydrogen atom or C1-20 alkyl group, and R13 to R18 and R23 to R28 each independently represent a hydrogen atom; a C1-20 alkyl group or alkoxy group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a C2-20 alkenyl group or alkynyl group optionally substituted with a halogen atom, hydroxyl group, amino group, nitro group or carboxyl group; a hydroxyl group; a halogen atom; an amino group; a nitro group; or a carboxyl group).
摘要翻译： 本发明提供含有式（1）或（2）表示的偶氮苯衍生物的寡核苷酸：（式中，A1和A2各自独立地表示氢原子，核苷酸或寡核苷酸，B1和B2各自独立地表示羟基， 核苷酸或寡核苷酸，R 11和R 12各自独立地表示C 1-20烷基，R 21和R 22各自独立地表示氢原子或C 1-20烷基，R 13〜R 18和R 23〜R 28各自独立地表示氢原子; C1 -20任选被卤素原子，羟基，氨基，硝基或羧基取代的烷基或烷氧基;任选被卤素原子取代的C 2-20烯基或炔基，羟基，氨基，硝基 或羧基;羟基;卤素原子;氨基，硝基或羧基）。
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