公开(公告)号：US07399781B2

公开(公告)日：2008-07-15

申请号：US11329505

申请日：2006-01-10

申请人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

发明人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

IPC分类号： A61K31/381 ,  C07D333/62

CPC分类号： C07D333/62 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

摘要翻译： 本发明涉及N-取代苯并噻吩磺酰胺衍生物或其药学上可接受的盐及其应用。 此外，它提供了一种用于预防或治疗由基于糜酶活性或通过活化肥大细胞的血管紧张素II或内皮素I的产生异常增加引起的心脏或血液循环疾病等的药剂和用于预防手术后粘连的药剂， 其中所述药剂对胃促胰酶具有选择性抑制作用。

公开(公告)号：US20060116408A1

公开(公告)日：2006-06-01

申请号：US11329505

申请日：2006-01-10

申请人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

发明人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

IPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/4178 ,  A61K31/4025 ,  A61K31/381 ,  C07D409/02

CPC分类号： C07D333/62 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

公开(公告)号：US07071220B2

公开(公告)日：2006-07-04

申请号：US10388378

申请日：2003-03-13

申请人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

发明人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

IPC分类号： A61K31/425 ,  A61K31/42 ,  A61K31/415 ,  C07D233/02 ,  C07D277/28

CPC分类号： C07D333/62 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.