公开(公告)号：US07071220B2

公开(公告)日：2006-07-04

申请号：US10388378

申请日：2003-03-13

申请人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

发明人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

IPC分类号： A61K31/425 ,  A61K31/42 ,  A61K31/415 ,  C07D233/02 ,  C07D277/28

CPC分类号： C07D333/62 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

公开(公告)号：US20060116408A1

公开(公告)日：2006-06-01

申请号：US11329505

申请日：2006-01-10

申请人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

发明人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

IPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/4178 ,  A61K31/4025 ,  A61K31/381 ,  C07D409/02

CPC分类号： C07D333/62 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

公开(公告)号：US07399781B2

公开(公告)日：2008-07-15

申请号：US11329505

申请日：2006-01-10

申请人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

发明人： Shoji Satoh ,  Akira Tatsui ,  Takeshi Hasegawa ,  Hideki Yamada ,  Shin-ichi Kazayama ,  Takahiro Morita ,  Hidekazu Masaki ,  Atsuo Takahashi ,  Fumiya Yoneyama ,  Tetsuo Kuze ,  Yusuke Mizuno ,  Mizuo Miyazaki ,  Shinji Takai

IPC分类号： A61K31/381 ,  C07D333/62

CPC分类号： C07D333/62 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to an N-substituted benzothiophenesulfonamide derivative or a pharmaceutically acceptable salt thereof and applications thereof. Furthermore, it provides an agent for preventing or treating cardiac or circulatory disease and so on caused by abnormal increase of production of angiotensin II or endothelin I based on chymase activity, or by activation of mast cell, and an agent for preventing adhesion after surgery, wherein the agent has a selective inhibitory action on chymase.

摘要翻译： 本发明涉及N-取代苯并噻吩磺酰胺衍生物或其药学上可接受的盐及其应用。 此外，它提供了一种用于预防或治疗由基于糜酶活性或通过活化肥大细胞的血管紧张素II或内皮素I的产生异常增加引起的心脏或血液循环疾病等的药剂和用于预防手术后粘连的药剂， 其中所述药剂对胃促胰酶具有选择性抑制作用。

公开(公告)号：US06258829B1

公开(公告)日：2001-07-10

申请号：US09367873

申请日：1999-09-03

申请人： Atsuo Takahashi ,  Kaoru Genkyou ,  Sachiko Yoneyama ,  Kazuyuki Aihara ,  Takashi Satoh ,  Fumiya Yoneyama ,  Jun Sasamori ,  Shin-ichi Yamada ,  Tetsuo Kimura ,  Kentaro Kogi

发明人： Atsuo Takahashi ,  Kaoru Genkyou ,  Sachiko Yoneyama ,  Kazuyuki Aihara ,  Takashi Satoh ,  Fumiya Yoneyama ,  Jun Sasamori ,  Shin-ichi Yamada ,  Tetsuo Kimura ,  Kentaro Kogi

IPC分类号： A61K31435

CPC分类号： C07D221/04 ,  C07D215/54 ,  C07D215/60 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D409/06 ,  C07D491/04 ,  C07D491/10 ,  C07F7/1804

摘要： This invention relates to a cycloalka[b]pyridine-3-carbonylguanidine derivative represented by the following general formula (1): and a salt thereof, which can provide a drug having sodium/proton (Na+/H+) exchange transport inhibitory action.

摘要翻译： 本发明涉及可以提供具有钠/质子（Na + / H +）交换转运抑制作用的药物的由以下通式（1）表示的环烷并[b]吡啶-3-羰基胍衍生物及其盐。

公开(公告)号：US06194676B1

公开(公告)日：2001-02-27

申请号：US09594546

申请日：2000-06-14

申请人： Atsuo Takahashi ,  Yasuo Takii

发明人： Atsuo Takahashi ,  Yasuo Takii

IPC分类号： H01H2500

CPC分类号： B60Q1/425

摘要： A mechanism for releasing an excess load with a simple construction when the excess load is applied during a cancel operation for automatically restoring an operating lever. A movable member is swingably supported by a holder mounted to an operating lever, and a spring is provided between the movable member and a driving member, whereby the movable member is biased toward the stable position of the holder, and the driving member is brought into press contact with a cam surface of a case. When the operating lever is rotated from the neutral position to the operating position, the driving member slides on the cam surface and is held in the operating position, and a first lever member comes into the rotation path of a cancel protrusion. When in this condition the steering wheel is turned in the opposite direction, the cancel protrusion abuts the first lever member to rotate during the return operation thereof, and with that, a second lever member rotates. As a result, the periphery of an opening of the second lever member pressurizes a receiving portion of the movable member, and due to this pressurizing force, the operating lever is automatically restored to the neutral position.

摘要翻译： 一种用于在用于自动恢复操作杆的取消操作期间施加过量负载时以简单结构释放过剩负载的机构。 可动构件由安装在操作杆上的保持架可摆动地支撑，并且在可动构件和驱动构件之间设置有弹簧，由此可动构件朝向保持器的稳定位置偏置，驱动构件 与壳体的凸轮表面压接。 当操作杆从中立位置旋转到操作位置时，驱动构件在凸轮表面上滑动并保持在操作位置，并且第一杆构件进入取消突起的旋转路径。 当在这种情况下方向盘沿相反方向转动时，抵消突起抵靠第一杆件在其返回操作期间旋转，并且第二杆件旋转。 结果，第二杆构件的开口的周边对可动构件的容纳部分加压，并且由于该加压力，操作杆自动地恢复到中立位置。

公开(公告)号：US08136424B2

公开(公告)日：2012-03-20

申请号：US12763961

申请日：2010-04-20

申请人： Atsuo Takahashi ,  Tatsuya Yokoyama

发明人： Atsuo Takahashi ,  Tatsuya Yokoyama

IPC分类号： B62D1/04 ,  G05G1/10 ,  G05G11/00 ,  G05G13/00

CPC分类号： B62D1/046 ,  B60K20/06 ,  B60Q1/0082 ,  B60Q5/003 ,  F16H59/02 ,  F16H2059/0239 ,  F16H2059/0247 ,  Y10T74/20256 ,  Y10T74/20834

摘要： Rotary support bodies which support both ends of a rod penetrating a manipulating knob body are formed by joining a first rotary support member which is arranged at one side of the manipulating knob body and supports one end of the rod and a second rotary support member which is arranged at another side of the manipulating knob body and supports another end of the rod, and one end of the rod is fixed to the second rotary support member, and another end of the rod is engaged with the first rotary support member. Accordingly, a manipulating knob can be mounted on a casing in a state the manipulating knob is mounted on the rotary support body.

摘要翻译： 通过连接布置在操作旋钮体的一侧并支撑杆的一端的第一旋转支撑构件和支撑杆的一端的第二旋转支撑构件，形成支撑穿过操纵旋钮体的杆的两端的旋转支撑体， 设置在操纵旋钮体的另一侧并支撑杆的另一端，并且杆的一端固定到第二旋转支撑构件，杆的另一端与第一旋转支撑构件接合。 因此，操作旋钮可以在操纵旋钮安装在旋转支撑体上的状态下安装在壳体上。

公开(公告)号：US5728835A

公开(公告)日：1998-03-17

申请号：US575062

申请日：1995-12-19

申请人： Tsuyoshi Aoki ,  Atsuo Takahashi ,  Hiroyasu Sato ,  Eiji Shimanuki ,  Kaoru Gengyou ,  Toyoki Nishimata ,  Sachiko Ishigami ,  Shin-ichi Yamada ,  Takahiro Yamaguchi ,  Yoichi Manome ,  Isamu Sato ,  Kentaro Kogi ,  Sen-ichi Narita

发明人： Tsuyoshi Aoki ,  Atsuo Takahashi ,  Hiroyasu Sato ,  Eiji Shimanuki ,  Kaoru Gengyou ,  Toyoki Nishimata ,  Sachiko Ishigami ,  Shin-ichi Yamada ,  Takahiro Yamaguchi ,  Yoichi Manome ,  Isamu Sato ,  Kentaro Kogi ,  Sen-ichi Narita

IPC分类号： A61K31/445 ,  C07D211/32

CPC分类号： A61K31/445 ,  C07D211/32

摘要： A substituted cyclic amine compound represented by the following general formula (1) ##STR1## wherein each of R.sup.1 to R.sup.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the like, A represents a carbonyl group or a sulfonyl group, B represents a methine moiety or a nitrogen atom, D represents a methine moiety, a nitrogen atom or .dbd.N(.fwdarw.O)-- and n is an integer of 2 to 3; and synthetic methods thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripheral circulatory disease and the like.

摘要翻译： 由下列通式（1）表示的取代环胺化合物其中R 1至R 5各自表示氢原子，卤素原子，低级烷基，低级烷氧基等，A表示 羰基或磺酰基，B表示次甲基部分或氮原子，D表示次甲基部分，氮原子或= N（ - O） - ，n为2〜3的整数。 及其合成方法。 本发明化合物可用于预防和治疗诸如高血压，缺血性心脏病，脑血管病，外周血循环疾病等循环器官相关疾病。

公开(公告)号：US20100200376A1

公开(公告)日：2010-08-12

申请号：US12763961

申请日：2010-04-20

申请人： Atsuo Takahashi ,  Tatsuya Yokoyama

发明人： Atsuo Takahashi ,  Tatsuya Yokoyama

IPC分类号： H01H9/00

CPC分类号： B62D1/046 ,  B60K20/06 ,  B60Q1/0082 ,  B60Q5/003 ,  F16H59/02 ,  F16H2059/0239 ,  F16H2059/0247 ,  Y10T74/20256 ,  Y10T74/20834

摘要： Rotary support bodies which support both ends of a rod penetrating a manipulating knob body are formed by joining a first rotary support member which is arranged at one side of the manipulating knob body and supports one end of the rod and a second rotary support member which is arranged at another side of the manipulating knob body and supports another end of the rod, and one end of the rod is fixed to the second rotary support member, and another end of the rod is engaged with the first rotary support member. Accordingly, a manipulating knob can be mounted on a casing in a state the manipulating knob is mounted on the rotary support body.

摘要翻译： 通过连接布置在操作旋钮体的一侧并支撑杆的一端的第一旋转支撑构件和支撑杆的一端的第二旋转支撑构件，形成支撑穿过操纵旋钮体的杆的两端的旋转支撑体， 设置在操纵旋钮体的另一侧并支撑杆的另一端，并且杆的一端固定到第二旋转支撑构件，杆的另一端与第一旋转支撑构件接合。 因此，操作旋钮可以在操纵旋钮安装在旋转支撑体上的状态下安装在壳体上。

公开(公告)号：US07762159B2

公开(公告)日：2010-07-27

申请号：US10645249

申请日：2003-08-21

申请人： Atsuo Takahashi ,  Tatsuya Yokoyama

发明人： Atsuo Takahashi ,  Tatsuya Yokoyama

IPC分类号： B62D1/04 ,  G05G1/10 ,  G05G11/00 ,  G05G13/00

CPC分类号： B62D1/046 ,  B60K20/06 ,  B60Q1/0082 ,  B60Q5/003 ,  F16H59/02 ,  F16H2059/0239 ,  F16H2059/0247 ,  Y10T74/20256 ,  Y10T74/20834

摘要： Rotary support bodies which support both ends of a rod penetrating a manipulating knob body are formed by joining a first rotary support member which is arranged at one side of the manipulating knob body and supports one end of the rod and a second rotary support member which is arranged at another side of the manipulating knob body and supports another end of the rod, and one end of the rod is fixed to the second rotary support member, and another end of the rod is engaged with the first rotary support member. Accordingly, a manipulating knob can be mounted on a casing in a state the manipulating knob is mounted on the rotary support body.

摘要翻译： 通过连接布置在操作旋钮体的一侧并支撑杆的一端的第一旋转支撑构件和支撑杆的一端的第二旋转支撑构件，形成支撑穿过操纵旋钮体的杆的两端的旋转支撑体， 设置在操纵旋钮体的另一侧并支撑杆的另一端，并且杆的一端固定到第二旋转支撑构件，杆的另一端与第一旋转支撑构件接合。 因此，操作旋钮可以在操纵旋钮安装在旋转支撑体上的状态下安装在壳体上。

公开(公告)号：US20070000761A1

公开(公告)日：2007-01-04

申请号：US11475436

申请日：2006-06-26

申请人： Atsuo Takahashi

发明人： Atsuo Takahashi

IPC分类号： H01H9/00

CPC分类号： B60Q1/1461

摘要： An automotive combination switch includes a housing having an opening through which a steering shaft passes, and a stork switch having a switch box, that is inserted and mounted in the housing and a manipulating rod protruding from the switching box. Snaps protruding from the outsides of walls of the switching box are snap-fitted into locking holes formed on walls of the housing. A claw of each snap is in elastical contact with a periphery of each locking hole by providing an elastic plate in the housing, and elastically contacting the elastic plate to a front of the switch box in the inserting direction.

摘要翻译： 汽车组合开关包括具有转向轴穿过的开口的壳体和插入并安装在壳体中的具有开关盒的鹳开关和从开关盒突出的操纵杆。 从开关盒的外壁突出的卡扣卡合到形成在壳体的壁上的锁定孔中。 每个卡扣的爪通过在壳体中提供弹性板而与每个锁定孔的周边弹性接触，并且在插入方向上将弹性板弹性接触开关盒的前部。