公开(公告)号：US20090202569A1

公开(公告)日：2009-08-13

申请号：US12225882

申请日：2007-04-06

申请人： Tetsuo Mashima ,  Takashi Tsuruo ,  Hideaki Tojo ,  Hiroyuki Sumi

发明人： Tetsuo Mashima ,  Takashi Tsuruo ,  Hideaki Tojo ,  Hiroyuki Sumi

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07H21/02 ,  A61K31/7088 ,  C12N5/06

CPC分类号： A61K45/06 ,  A61K31/7088 ,  A61K39/395 ,  A61K2300/00

摘要： The present invention provides a preventative/therapeutic agent for cancer capable of selectively and effectively killing cancer cells. A medicament of the present invention prepared by combining at least one selected from a substance that inhibits the activity of an enzyme belonging to the acyl-CoA synthase family and a substance that inhibits expression of a gene for an enzyme belonging to the acyl-CoA synthase family, with at least one selected from a substance that inhibits the activity of fatty acid synthase and a substance that inhibits expression of a fatty acid synthase gene and the like can be used as a preventative/therapeutic agent for cancer capable of selectively and effectively killing cancer cells.

摘要翻译： 本发明提供了能够选择性且有效地杀死癌细胞的癌症预防/治疗剂。 通过组合选自抑制属于酰基辅酶A合成酶家族的酶的活性的物质和抑制属于酰基辅酶A合成酶的酶的基因表达的物质中的至少一种而制备的本发明的药物 可以使用选自抑制脂肪酸合酶活性的物质中的至少一种和抑制脂肪酸合酶基因表达的物质等作为能够选择性有效杀死的癌症的预防/治疗剂 癌细胞。

公开(公告)号：US20090155241A1

公开(公告)日：2009-06-18

申请号：US11988995

申请日：2005-07-22

申请人： Tetsuo Mashima ,  Takashi Tsuruo

发明人： Tetsuo Mashima ,  Takashi Tsuruo

IPC分类号： A61K39/395 ,  C07H21/02 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/00 ,  A61K31/7088 ,  C12N9/96 ,  C07C245/00

CPC分类号： G01N33/573 ,  A61K38/00 ,  A61K49/0008 ,  C12N9/93 ,  C12Y602/01003 ,  G01N33/574 ,  G01N2333/91051 ,  G01N2800/52

摘要： A compound or its salt that inhibits the activity of a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1; a compound or its salt that inhibits the expression of a gene for the protein; an antisense polynucleotide comprising a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding the protein or a partial peptide thereof or a part of the nucleotide sequence; an antibody against the protein; etc. are useful as preventive/therapeutic agents for cancer, apoptosis promoters for cancer cells, or the like.

摘要翻译： 抑制与SEQ ID NO：1所示的氨基酸序列具有相同或基本相同的氨基酸序列的蛋白质的活性的化合物或其盐; 抑制蛋白质基因表达的化合物或其盐; 反义多核苷酸，其包含与编码所述蛋白质或其部分肽或所述核苷酸序列的一部分的多核苷酸的核苷酸序列互补或基本互补的核苷酸序列; 抗蛋白的抗体; 等可用作癌症的预防/治疗剂，癌细胞的凋亡启动子等。